Metastatic Ovarian Cancer: Bibliographic Analysis

Abstract

Introduction. Ovarian cancer is an oncogynecological disease with high mortality. High mortality caused by this pathology is associated with diagnosis at the III–IV stage of the disease. This stage of the disease is characterized by metastasis and reflected in the 5-year survival rate, decreasing to 30.2 %. At the same time, when diagnosed at the I-II stage, this indicator is 92.6%. The aim of the work is bibliometric analysis and generalization of data from scientific sources on the study of ovarian cancer metastasis. Materials and methods. Information was searched on electronic resources of the Scopus, Web of Science, PubMed, and Google Scholar databases using the keywords "ovarian cancer" and "metastases." An online platform for monitoring and analyzing scientific sources was used for bibliometric analysis. We used several VOSviewer bibliometric network visualization system tools and SciVal (Scopus) modern citation requirements. Results. It has been established that metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. The influence of E-cadherin, MMP-2, and transglutaminase-2 on metastasis processes was evaluated. Also, the role of cytokines in the invasiveness of the tumor process and metastasis was established. The results of bibliometric analysis of scientific sources showed that over the past 20 years, the number of publications on ovarian cancer metastasis has increased significantly, and the most widely given topic is studied in the USA and China. Conclusions. Metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. It was found that among the analyzed 496 publications, the most relevant directions are molecular-biological and signaling pathways, which are described in many ways in scientific sources on ovarian cancer metastasis. The calcification of peritoneal metastases and their formation mechanism are currently not investigated, and there is no thorough explanation that may become a perspective for further research.