E-cadherin/Catenin Complex Status in Solid Pseudopapillary Tumor of the Pancreas

El‐Bahrawy, Mona; Rowan, Andrew; Horncastle, Donna; Tomlinson, Ian; Theis, B; Russell, R. C. G.; Stamp, Gordon

doi:10.1097/pas.0b013e31813e0676

Cited by 80 publications

(54 citation statements)

References 39 publications

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“…8,14,29 While nuclear expression of β-catenin is generally well recognized in several tumor types, it has not yet been detected in CPTs. Nuclear expression of E-cadherin has only been discovered recently in several human tumor types 6,9,12 and in canine anal sac gland carcinoma. 22 It is thought that decreased or aberrant expression may remove the regulatory effect of contact inhibition on proliferation, thus allowing an escape from growth control signals resulting in unrestricted replication of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Aberrant E-cadherin, β-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors

et al. 2011

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Abstract.Expression of E-cadherin and β-catenin has been widely studied in various human and canine epithelial tumors and has been correlated with dedifferentiation, invasiveness, and metastasis. Choroid plexus tumors (CPTs) are of epithelial origin, and the most important prognostic factor in human medicine is the tumor grade. Limited information is available regarding E-cadherin and β-catenin expression in human CPTs, and no information is found in the veterinary literature. In the current study, 42 canine CPTs (19 choroid plexus papillomas and 23 choroid plexus carcinomas) were retrospectively reviewed, and the intensity and cellular staining pattern of E-cadherin and β-catenin were correlated with histological features, paying special attention to grade, invasion, and metastasis. In addition, cytokeratin and glial fibrillary acidic protein (GFAP) antibodies were evaluated as markers for canine CPTs. It was found that loss of E-cadherin and β-catenin expression was uncommon in canine CPTs. Rather, membranous expression of both molecules was increased in CPTs compared to normal choroid plexus (NCP), regardless of tumor grade. Additionally, aberrant cytoplasmic or nuclear expression of both E-cadherin and β-catenin was often observed in CPTs. GFAP was frequently expressed in CPTs in contrast to NCP. None of these parameters were correlated with malignancy, and therefore, do not appear to be useful for prognostic information. Nevertheless, a panel of antibodies including E-cadherin and GFAP might be useful to support the diagnosis of CPTs and help to differentiate them from other tumors, such as ependymomas and metastatic epithelial tumors.

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Section: Discussionmentioning

confidence: 99%

Aberrant E-cadherin, β-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors

et al. 2011

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“…Recent studies have also highlighted the genetic and immunophenotypic expression patterns of b-catenin and E-cadherin in SPN and PEN. [29][30][31] In conclusion, we wish to highlight that large, clear cytoplasmic vacuoles can serve as a critical clue with which to distinguish SPN from PEN in diagnostically challenging cases. In such cases, adequate samples should be obtained to perform supportive ancillary studies as needed.…”

Section: Discussionmentioning

confidence: 99%

Large, clear cytoplasmic vacuolation

Jhala

Siegal

Jhala

2008

Cancer

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BACKGROUND. Solid pseudopapillary neoplasm (SPN) and pancreatic endocrine neoplasm (PEN) are uncommon neoplasms that demonstrate characteristic cytologic features. It is also known that both these tumors may share similar morphologic changes. These features not uncommonly pose significant diagnostic challenge for unsuspecting cytopathologists. In the current study, the authors report that recognition of clear cytoplasmic vacuoles in endoscopic ultrasound–guided fine–needle aspiration (EUS‐FNA) samples from SPN serves as a useful clue that can distinguish this tumor from PEN. METHODS. The cytologic features from 5 SPN and 20 PEN cases were evaluated. Both Diff‐Quik and Papanicolaou stains from these cases were examined. A Fisher exact test of probability was performed to determine differences in the individual cytologic features noted in these 2 tumor types. RESULTS. The results demonstrated that pseudopapillary groups (P = .004); metachromatic matrix material (P = .004); nuclear membrane irregularity (P = .004); and large, clear cytoplasmic vacuoles (P = .001) are noted significantly more frequently in SPN. The authors also demonstrated that large, clear cytoplasmic vacuoles can serve as a powerful cytologic clue for the suspicion of SPN over PEN when there is a paucity of papillary groups within the smears. Large, clear cytoplasmic vacuoles, however, were noted only in Diff‐Quik–stained smears, but not in Papanicolaou‐;stained smears. CONCLUSIONS. The results of the current study highlight that large, clear cytoplasmic vacuoles can serve as a critical clue with which to distinguish SPN from PEN in diagnostically challenging cases. Cancer (Cancer Cytopathol) 2008. © 2008 American Cancer Society.

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“…Clearly, a continued mutational analysis of CTNNB1 will be required to identify alternate mechanisms that could be responsible for the progression of SPN. Similarly, the nuclear immunoreactivity of Ecadherin with the loss of membrane staining is present in all SPN cases studied (25); however, unlike with β-catenin, no mutations were identified in the E-cadherin gene (CDH1) in SPN (26). Therefore, the nuclear localization of E-cadherin cannot be attributed to mutations of CDH1 (26).…”

Section: B-f) Hematoxylin and Eosin Staining Shows Pseudopapillary Pmentioning

confidence: 98%

“…Although the efficacy of various antigens including CD56, vimentin and neuronspecific enolase has been evaluated, an immunohistchemical analysis with an antibody raised to a particular molecule is not completely unique to a single kind of tumor (1-3). However, antibodies specific for E-cadherin and β-catenin can distinguish SPN from other pancreatic tumors and their use should be considered for the differential diagnosis (4,26). The distinction among various types of pancreatic tumors before surgical treatment is critically important for effective treatment.…”

Section: B-f) Hematoxylin and Eosin Staining Shows Pseudopapillary Pmentioning

confidence: 99%

Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

et al. 2013

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Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of CTNNB1. We also present a review of the literature describing the clustering of CTNNB1 mutations in patients with SPN.

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E-cadherin/Catenin Complex Status in Solid Pseudopapillary Tumor of the Pancreas

Cited by 80 publications

References 39 publications

Aberrant E-cadherin, β-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors

Aberrant E-cadherin, β-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors

Large, clear cytoplasmic vacuolation

Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

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