E-001 association Between Reflux Esophagities and Blood Pressure

Abstract

Background Reflux esophagitis (RE) is main manifestation of gastroesophageal reflux disease with esophageal injury. We aimed to evaluate the blood pressure among RE patients after diagnosis compared to non-RE patients.Methods Seventy-four RE patients (39 male/35 female; mean age: 42.2 AE 14.3 years) were enrolled in this study. RE patients were those who had heartburn and/ or regurgitation with endoscopy-positive erosion(s) in the distal esophagus. Seventeen non_RE patients (7 male/10 female; mean age: 40.7 AE 12.1 years) were those who had not history and symptoms of gatroesophageal reflux disease in endoscopy. Their age, body mass index, systolic and diastolic blood pressures were recorded. ResultsThe levels of systolic blood pressure in RE patients were significantly higher than in those non-ER patients. (87.0 AE 17.9 vs. 75.3 AE 12.8 mmHg, respectively; p ¼ 0.013). Also, there was significant increasing in the levels of diastolic blood pressure between RE and non_RE patients (131.6 AE 20.7 vs. 117.2 AE 20.0, respectively; p ¼ 0.008). There were no significant differences in BMI of RE patients versus non-RE patients (25.7 AE 4.7 vs. 26.0 AE 5.0, respectively, p ¼ 0.806).Conclusions We found an association between experiencing heartburn and/ or acid regurgitation with blood pressure. Confirmation of these findings, and further investigation of the pathophysiological role that biochemical parameters may play in RE, and possibly Barrett's esophagus, are warranted.Objectives The accuracy of noninvasively estimated central systolic blood pressure (SBP) remains controversial. The present study investigated the accuracy of a new oscillometric method by direct comparison with the analysis of the invasive brachial pressure waveform.Methods We enrolled 50 patients (37 men, age range 30-84 years) indicated for cardiac catheterization. Right brachial pressure and central aortic pressure were simultaneously recorded using a dual-sensor pressure catheter, at steady state and 3 minutes after administration of a sublingual nitroglycerin. Noninvasive left arm SBP and diastolic blood pressure (DBP) were also simultaneously measured using an oscillometric blood pressure monitor that was designed to record pulse volume phlethysmography (PVP) immediately after the measurement of noninvasive blood pressures. Central SBP was estimated by the recently proposed comprehensive analysis of the PVP waveform calibrated by the noninvasive SBP and DBP, and also by identification of the late systolic shoulder (SBP2) of the invasive brachial pressure waveform. The reproducibility of the invasive central SBP by the noninvasive and invasive estimation methods was examined using the concordance correlation coefficient.Results Overall, the invasive central aortic SBP ranged 85.6$175.5 with a mean of 123.6 AE 20.5 mmHg. The concordance correlation coefficient for the noninvasively estimated central SBP was 0.93 (95% CI 0.91$0.95), which was significantly better than that for the noninvasive SBP (0.87, 0.83$0.90) and was not significantly different ...