Dystrophic Calcification of an Implanted Hydroxyethylmethacrylate Intraocular Lens

Bucher, P. J. M.

doi:10.1001/archopht.1995.01100110091031

Cited by 75 publications

(47 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20][21][22][23][24][25][26][27] Deposits have been found on all 3 commercially available hydrophilic acrylic IOLs (SC60B-OUV, Medical Developmental Research Inc.; Aqua-Sense, Ophthalmic Innovations International Inc.; Hydroview H60M). [20][21][22][23] These finding suggest that hydroxyethyl methacrylate (HEMA) is involved in deposit formation as all these hydrophilic acrylic materials contain HEMA. We believe hydrophilic acrylic materials may lead to calcification as it has been reported that HEMA-based IOL materials calcified within animal muscles in an experimental comparison of materials.…”

Section: Discussionmentioning

confidence: 99%

Calcification of Hydroview H60M intraocular lenses: Aqueous humor analysis and comparisons with other intraocular lens materials

Nakanome¹,

Watanabe²,

Tanaka³

et al. 2008

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Calcification of Hydroview H60M intraocular lenses: Aqueous humor analysis and comparisons with other intraocular lens materials

Nakanome¹,

Watanabe²,

Tanaka³

et al. 2008

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

show abstract

“…Histopathological analysis of the lenses demonstrated irregular granular deposits on the surface of the optics which stained positive for calcium. 4 Significant deposition of crystalline material on the surface of IOLs is uncommon but has been reported intra-operatively on silicone 8 lenses and early in the postoperative period on hydrogel 9 lenses. Similar calcium deposition associated with spoilation of soft contact lenses 10 following extended wear has also been known for some time.…”

Section: Discussionmentioning

confidence: 99%

Late surface opacification of Hydroview® intraocular lenses

Habib¹,

Freegard²,

Gock³

et al. 2002

Eye

View full text Add to dashboard Cite

Methods Twenty one eyes which underwent uncomplicated phacoemulsification and Hydroview lens implantation with good visual recovery, presenting at 46-146 weeks post-surgery with visual deterioration and glare symptoms resulting from opacification of the implants, were included in the study. Twelve eyes had severe opacification, of which nine underwent intraocular lens exchange and three more are still awaiting surgery. The method of explantation is described. The explanted intraocular lenses were examined using light microscopy, scanning electron microscopy and x-ray microanalysis using a light element detector. Results Light microscopy and scanning electron microscopy revealed diffuse granular deposits of approximately 5 m diameter covering the optic surfaces but sparing the lens haptics. Light microscopic staining techniques and x-ray microanalysis confirm the major component of the deposits to be calcium phosphate salts. Conclusions Late opacification of Hydroview intraocular lens implants is uncommon and aetiology seems to be multifactorial. Implant exchange is necessary to restore sight in some cases. As new materials are increasingly used it is important to highlight such unusual occurrences. Eye (2002) 16, 69-74.

show abstract

“…[34][35][36][37][38][39] Indeed, hydroxyapatite is the thermodynamically stable phase of calcium phosphate in biological systems. Calcium and phosphate are present in blood and interstitial fluids at levels that nearly exceed their solubility product.…”

Section: Calcification Of Modern Foldable Hydrogel Intraocular Lens Dmentioning

confidence: 99%

Calcification of modern foldable hydrogel intraocular lens designs

Izak

Werner

Pandey

et al. 2003

Eye

121

114

View full text Add to dashboard Cite

Purpose To report and compare clinical and pathological features of hydrophilic acrylic intraocular lenses (IOLs) of three major designs, explanted from patients who had visual disturbances caused by opacification of the lens optic. Methods Eighty-seven hydrophilic acrylic IOLs (25 Hydroview TM , 54 SC60B-OUV, and 8 Aqua-Sense TM lenses) were explanted and sent to our center. Most patients became symptomatic during the second year after cataract surgery. A fine granularity was observed on the surface of the lens optic in the case of Hydroview TM . With the SC60B-OUV and Aqua-Sense TM lenses, the opacity resembled a nuclear cataract. Gross examination, light microscopy and staining with alizarin red and the von Kossa method (for calcium) were performed. Some lenses were submitted for scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Results Light microscopic and SEM analyses revealed the presence of irregular granular deposits on the external optical surfaces of Hydroview TM lenses. With the SC60B-OUV lenses, the opacity was caused by the presence of multiple fine, granular deposits within the lens optic, distributed in a line parallel to the anterior and posterior curvatures of the optic, with a clear zone just beneath its external surfaces. The Aqua-Sense TM lenses exhibited both patterns simultaneously. The deposits in all cases stained positive with alizarin red and von Kossa method. EDS also demonstrated the presence of calcium and phosphates within the deposits. Conclusion Differences in the water content of the hydrophilic acrylic materials used in the manufacture of these three lens designs may be responsible for the different patterns of calcium precipitation. Careful clinical follow up of patients implanted with these lenses is necessary to determine if this phenomenon is rare and sporadic or may be more widespread.

show abstract

Dystrophic Calcification of an Implanted Hydroxyethylmethacrylate Intraocular Lens

Cited by 75 publications

References 18 publications

Calcification of Hydroview H60M intraocular lenses: Aqueous humor analysis and comparisons with other intraocular lens materials

Calcification of Hydroview H60M intraocular lenses: Aqueous humor analysis and comparisons with other intraocular lens materials

Late surface opacification of Hydroview® intraocular lenses

Calcification of modern foldable hydrogel intraocular lens designs

Contact Info

Product

Resources

About