Dysregulation of serum NADPH oxidase1 and ferritin levels provides insights into diagnosis of Parkinson's disease

Hemmati-Dinarvand, Mohsen; Taheraghdam, Aliakbar; Mota, Ali; Vahed, Sepideh Zununi; Samadi, Nasser

doi:10.1016/j.clinbiochem.2017.09.014

Cited by 23 publications

(7 citation statements)

References 37 publications

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“…We performed a screening of the abstracts of all original articles, and publications in abstract form were excluded from further analysis. The initial selection included 76 studies measuring CSF, serum/plasma or urine levels of iron, ferritin, transferrin, lactoferrin, haptoglobin, and or hepcidine [6,9–83]. Table 2 summarizes the methods used for the determinations, the main results, and observations in some of these studies, including the reason for exclusion of several of these studies from the meta‐analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Table 2 summarizes the methods used for the determinations, the main results, and observations in some of these studies, including the reason for exclusion of several of these studies from the meta-analysis. Reasons for total and partial exclusion included the following: (i) total or partial overlapping with other articles from the same author group [6,21,28,32,39,42,52,54,61,69,78,80]; (ii) lack of a control group [13,38,49,59,75]; (iii) lack of portions of the data in the text, tables or figures [12,55]; (iv) measurement of relative but not absolute values of the variables studied [37,44,62,70]; and (v) inability to obtain the original article [9]. Selected case-control studies reporting CSF concentrations of iron (11 studies), ferritin (five studies), transferrin (two studies), and lactoferrin (one study) are summarized in Table S1.…”

Section: Criteria For Eligibility and Exclusion Of Studies From The Meta-analysesmentioning

confidence: 99%

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Biological fluid levels of iron and iron‐related proteins in Parkinson’s disease: Review and meta‐analysis

Jiménez‐Jiménez

Alonso‐Navarro

García‐Martín

et al. 2020

Euro J of Neurology

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Background and purpose Several studies suggested a role or iron in the pathogenesis or Parkinson's disease (PD), and substantia nigra iron concentrarions have been found increased in PD. However, the results on cerebrospinal (CSF) and serum/plasma iron levels in PD patients have been controversial. The aim of this systematic review and meta‐analysis was to establish the CSF and serum/plasma levels of iron and iron‐related proteins (ferritin, transferrin, lactoferrin, haptoglobin, and hepcidine) levels, and the urine levels of iron, in patients with PD. Methods Four databases (PubMed, EMBASE, MedLine, and Web of Science – Core Collection) were reviewed for studies published from 1966 to October 5, 2020. References of interest were identified. A meta‐analysis of eligible studies was performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) and Meta‐analysis of Observational Studies in Epidemiology (MOOSE) guidelines, using the R software package meta. Results A non‐significant trend towards higher CSF iron levels and marginally significantly lower serum/plasma iron levels was observed in patients with PD compared with age‐ and sex‐matched controls. CSF and serum/plasma ferritin and transferrin concentrations, and serum/plasma lactoferrin and haptoglobin concentrations did not differ significantly between PD patients and controls. Conclusion The findings of this study suggest an association between decreased serum/plasma iron levels and, possibly, higher CSF iron levels with risk of PD.

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Section: Methodsmentioning

confidence: 99%

Section: Criteria For Eligibility and Exclusion Of Studies From The Meta-analysesmentioning

confidence: 99%

Biological fluid levels of iron and iron‐related proteins in Parkinson’s disease: Review and meta‐analysis

Jiménez‐Jiménez

Alonso‐Navarro

García‐Martín

et al. 2020

Euro J of Neurology

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“…Although there seems to be altered iron management specifically within the SNpc, cerebrospinal fluid (CSF) levels of ferritin and serum ferritin levels were not significantly different between PD and non-PD patients [127]. In contrast however, there is a recent study detailing how serum ferritin may serve as a potential biomarker for diagnosis in PD [129]. In this study, the authors found an increased level of serum ferritin in PD patients when compared to non-PD patients.…”

Section: Ferritin As a Disease Biomarkermentioning

confidence: 99%

Emerging and Dynamic Biomedical Uses of Ferritin

Chiou

Connor

2018

Pharmaceuticals

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Ferritin, a ubiquitously expressed protein, has classically been considered the main iron cellular storage molecule in the body. Owing to the ferroxidase activity of the H-subunit and the nucleation ability of the L-subunit, ferritin can store a large amount of iron within its mineral core. However, recent evidence has demonstrated a range of abilities of ferritin that extends well beyond the scope of iron storage. This review aims to discuss novel functions and biomedical uses of ferritin in the processes of iron delivery, delivery of biologics such as chemotherapies and contrast agents, and the utility of ferritin as a biomarker in a number of neurological diseases.

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“…oxidative stress and mitochondrial dysfunction may play a role in the cellular levels of neurodegeneration (Angelova & Abramov, 2018;Hemmati-Dinarvand et al, 2017, 2019). Parkinson's disease, which has the second highest prevalence after Alzheimer's disease, is characterized by decreased dopamine levels in basal ganglia neurons and arises because of degeneration especially in substantia nigra pars compacta neurons.…”

Section: Cell Ell B Biology Iology I International Nternationalmentioning

confidence: 99%

“…Neurodegenerative diseases are characterized by progressive neuronal damage, eventually deterioration of neuron structure, and the initiation of cellular apoptosis processes, which usually occurs in advancing age (Przedborski et al, 2003). As a result of many recent studies, it has been emphasized that apoptosis, calcium signaling, oxidative stress and mitochondrial dysfunction may play a role in the cellular levels of neurodegeneration (Angelova & Abramov, 2018; Hemmati‐Dinarvand et al, 2017, 2019). Parkinson's disease, which has the second highest prevalence after Alzheimer's disease, is characterized by decreased dopamine levels in basal ganglia neurons and arises because of degeneration especially in substantia nigra pars compacta neurons.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model

Öz

Çelik

2023

Cell Biology International

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The transient receptor potential channel (TRP) channels are expressed in neuronal tissues and involved in neurological diseases such as pain, epilepsy, neuronal apoptosis, and neurodegenerative diseases. Formerly, we have investigated how neuronal differentiation changes TRP channels expression profile and how Parkinson's disease model is related with this expression levels. We have found that transient receptor potential channel melastatin subtype 7 (TRPM7), transient receptor potential channel melastatin subtype 8 and transient receptor potential channel vanilloid subtype 1 (TRPV1) channels have pivotal effects on differentiation and 1‐Methyl‐4‐phenylpyridinium (MPP+)‐induced Parkinson's disease model in SH‐SY5Y cells. In this study, we have investigated that downregulation of the TRP channels to evaluate how differentiation status changes to Parkinson's disease pathological hallmarks. We have also performed to other analyses to elucidate these TRP channels' function in MPP+‐induced neurotoxicity related apoptosis, cell viability, caspase 3 and 9 enzyme activities, intracellular reactive oxygen species production, mitochondrial depolarization levels, Ca2+ signaling, Alpha‐synuclein and Dopamine levels, mono amino oxidase A and B enzymatic activities, both in differentiated and undifferentiated neuronal cells. Herein we have concluded that especially TRPM7 and TRPV1 channels have distinct role in Parkinson's disease pathology via their activity changings in pathological state, and downregulation of these channels or specific antagonists can be useful for the possible treatment strategy for Parkinson's disease and related markers.

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Dysregulation of serum NADPH oxidase1 and ferritin levels provides insights into diagnosis of Parkinson's disease

Cited by 23 publications

References 37 publications

Biological fluid levels of iron and iron‐related proteins in Parkinson’s disease: Review and meta‐analysis

Biological fluid levels of iron and iron‐related proteins in Parkinson’s disease: Review and meta‐analysis

Emerging and Dynamic Biomedical Uses of Ferritin

Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model

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