Dysregulation of Lipid and Cholesterol Metabolism in High Fat Diet Fed Hyperlipidemic Rats: Protective Effect of Sida rhomboidea. roxb Leaf Extract

Abstract

The present study was undertaken to evaluate the efficacy of freeze dried extract of Sida rhomboidea.roxb leaves (FESR) on alteration in lipid and cholesterol metabolism in high fat diet induced hyperlipidemia in experimental rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FESR treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug lovastatin (LVS). Results indicate that FESR was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in S. Rhomboidea. roxb (SR). Use of SR extract as a potential therapeutic agent against hyperlipidemia is indicated.

Prevention of High Fat Diet Induced Insulin Resistance in C57BL/6J Mice by Sida rhomboidea ROXB. Extract

“…This observation is in accordance with our previous report 16) and the same has been attributed to presence of ephedrine in SR extract. 39) Oral acute and chronic toxicity studies performed in our laboratory with SR extract reveal that there were no adverse behavioural, biochemical and histopathological changes by oral administration of SR extract up to a dose of 3000 mg/kg bodyweight (unpublished observations).…”

“…These results are also in accordance with its previously reported lipid lowering property in HFD fed hyperlipidemic rats. 16) Synthetic antidiabetic drugs commercially available in the market are often not able to tackle dyslipidemia, thus raising the risk of cardiovascular complication. Hence, these results can be considered significant against diabetic dyslipidemia.…”

“…(SR) is used as a folklore medicine against obesity and diabetes in parts of North Eastern India. Recent studies from our laboratory have reported its hypolipidemic 16) and antihypertriglyceridemic 17) activities. However, there are no reports on therapeutic role of SR leaf extract against exper-imentally induced type II diabetes and insulin resistance.…”

Protective effect ofClerodendron glandulosumextract against experimentally induced metabolic syndrome in rats

“…Currently, the research focus has been shifted towards the use of herbs and other alternative medicines in the treatment of diabetes, hypertension and dyslipidemia, as synthetic compounds have shown a number of side effects despite their proven bioactivities (Amos et al, 2003;Granberry et al, 2007;Thounaojam et al, 2009). The World Health Organization (WHO) has in fact recommended use of indigenous plants as an alternative remedy, especially in developing countries (WHO, 2002) where 80% of the population still relies on medicines of herbal origin as the main source of healthcare (Calixto, 2000).…”

Assessment of lipid lowering effect ofSida rhomboidea.Roxbmethanolic extract in experimentally induced hyperlipidemia

“…[13][14][15][16] It is also considered beneficial in controlling fever, cardiovascular disease and urinary disorders. [17] Previous studies from our laboratory have documented that aqueous leaf extract of SR has lipid lowering [18] and anti hypertriglyceridemic properties [19] , whereas methanolic extract of SR has shown to have antioxidant and free radical scavenging properties (Unpublished observations). Hence, this inventory is an effort to assess the effect of SR on the lipid profile of experimentally induced hyperlipidemia in male Charles foster rats.…”