Assessment of lipid lowering effect of<i>Sida rhomboidea.Roxb</i>methanolic extract in experimentally induced hyperlipidemia

Dk, Patel; Ka, Patel; Uk, Patel; Thounaojam, MC; Rn, Jadeja; Ansarullah,; Gs, Padate; Sp, Salunke; Devkar, Ranjitsinh V.; Ramachandran, A. V.

doi:10.4103/0975-1483.57070

Cited by 17 publications

(2 citation statements)

References 23 publications

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“…[ 4 ] Extracts of gum ghatti of Anogeissus latifolia , Sida rhomboidea , soy protein, grape seeds, garlic, ginger, and citrus peel have been assessed for hypocholesterol activity. [ 5 6 7 8 9 10 11 ] In particular, many herbal extracts are studied for controlling the cholesterol level. One such plant is Mangifera indica L. (Family; Anacardiaceae) commonly known as Mango, a large evergreen tree of tropical and subtropical region of India and other Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats

Gururaja¹,

Mundkinajeddu²,

Kumar³

et al. 2017

Phcog Res

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Introduction:Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined.Materials and Methods:The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography.Results and Discussion:Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract.Conclusions:The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels.SUMMARYThe Mangifera indica leaves methanolic extract showed significant cholesterol lowering activity in high cholesterol diet induced hypercholesterolaemia model in rats when evaluated at a dose of 90 mg/kg rat body weight. The extract was found to contain Iriflophenone 3-C-β-D-glucoside and mangiferin which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity.

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Section: Introductionmentioning

confidence: 99%

Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats

Gururaja¹,

Mundkinajeddu²,

Kumar³

et al. 2017

Phcog Res

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“…The high phytochemical and antioxidant content of both malted and unmalted hungry rice may be to blame for the rise in HDL cholesterol. Several studies have proved that flavonoids increase HDL cholesterol concentration and reduce LDL and VLDL levels in the hypercholesterolemic rats [46]. Therefore, flavonoids content of malted and unmalted hungry rice could be responsible for the elevated HDL and decrease in LDL and total cholesterol in the experimental rats.…”

Section: Discussionmentioning

confidence: 96%

Modulation of the Expression of Lipogenic Activity by Malted Hungry Rice Flour (Digitaria exilis.) on Rats Induced with Obesity

Umerah

Asouzu

2023

AJRB

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Lipolysis and lipogenesis causes obesity and these can be mediated by hormones. The study was aimed at determining the effect of malted hungry rice flour on lipogenic activity on diet-induced obese rats. The study was conducted between September to January 2021 and 2022. Twenty male adult albino rats were divided into four groups and obesity was induced which resemble mild obesity condition in human. The groups for the experiment were normal control (AIN-93), obese control, and two test diets were used to evaluate lipid profile parameter using a standard assay technique. There is an increase in BMI (from 0.37-0.41 to 0.58- 0.72). There are also an increase in other lipid profile with a decrease in HDL (p<0.05) after consumption of a palatable diet. Consumption of the test diet led to a significant reduction in the lipid profile parameter, and a significant increase in HDL cholesterol compared to the (group) obese control (p<0.05). The result suggests that malted hungry rice flour has an anti-obesity effect.

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Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

Chowdhury

Hashem

et al. 2020

Anim Models and Exp Med

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Background: Justicia adhatoda and Ocimum tenuiflorum, locally known as bashok and tulsi, are two ethnomedicinally important herbs that have been using as dietary supplements for several therapeutic applications. This study evaluated the combined effect of both the herbs as an antioxidative and antihyperlipidemic agent.Methods: Antihyperlipidemic effect was assessed in a high-fat diet-induced hyperlipidemic model in Wistar albino rats. The rats were treated orally with extracts of bashok (J adhatoda, 200 mg/kg bw), tulshi (O tenuiflorum, 200 mg/kg bw), and a combination of bashok and tulshi (50:50), as well as with a reference drug, atorvastatin (10 mg/kg/day), with or without high-fat diet for 14 days. The antioxidative effect was studied using established in vitro models. The studies were supported by experimentally testing the effects of the extracts on membrane stabilization and inhibition of protein denaturation. Results:The results showed that the serum lipid profile was significantly decreased in the different treatment groups, with bashok having the greatest effect. Body weights, total serum protein, LDH, and relative liver and adipose tissue weights were markedly restored towards baseline values, the lowest atherogenic index being achieved with the combined extract. The combination treatment significantly enhanced total phenolic content and antioxidative capacity and greatly potentiated membrane stabilization, but inhibition of protein denaturation was not significantly affected. Conclusion:The data demonstrate that a combination of Justicia adhatoda and Ocimum tenuiflorum could be developed as a food supplement with antioxidative and antihyperlipidemic benefits.

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Assessment of lipid lowering effect ofSida rhomboidea.Roxbmethanolic extract in experimentally induced hyperlipidemia

Cited by 17 publications

References 23 publications

Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats

Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats

Modulation of the Expression of Lipogenic Activity by Malted Hungry Rice Flour (Digitaria exilis.) on Rats Induced with Obesity

Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

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