Dysregulation of interleukin‐10 production in relatives of patients with systemic lupus erythematosus

Abstract

Objective. To evaluate interleukin-10 (IL-10) production in relatives of patients with systemic lupus erythematosus (SLE).Methods. Production of IL-10 was evaluated in 13 families in which several members had SLE. The constitutive IL-10 production in SLE patients (n = 16) was compared with that in healthy members of these multiplex families (n = 70), in 30 SLE patients who had no relatives with SLE, and in 46 healthy unrelated controls.Results. The level of IL-10 production did not differ between SLE patients who were members and those who were not members of multiplex families (mean f SEM 4,384 f 908 pglml and 4,709 f 560 pglml, respectively), but was higher in both groups than in healthy unrelated controls (515 & 88 pglml). The healthy members of the multiplex families constitutively produced large amounts of IL-10 (3,080 -C 311 pglml; P < 0.001 compared with healthy unrelated controls).This high IL-10 production was independent of age and sex, and was similar in first-and second-degree relatives of SLE patients. The IL-10 was produced both by monocytes and by a subpopulation of B lymphocytes in SLE patients and in their relatives.Conclusion.

The Genetics of Systemic Lupus Erythematosus

“…In the same study, a synergistic effect between alleles of the IL-10 and bcl-2 genes in determining susceptibility SLE was found [61]. Interleukin-10 (IL-10) is interesting not only because of its involvement in apoptosis, but also because the high production of IL-10 seen in SLE patients and occasionally also in unaffected relatives [62,63]. Some studies of genetic markers within the IL-10 gene demonstrate associations to SLE [61,64], while others fail to find such association [65].…”

Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci

“…46,49,[51][52][53][54] IL10 secretion has been demonstrated in genital C. trachomatis infection 54 and increased IL10 expression found in active trachoma. 15 It has been thought that increased production of IL10 confers risk of severe disease by antagonism of the Th1 response necessary for clearance of chlamydial infection.…”

The pathophysiology of photosensitivity in lupus erythematosus

“…Increased production of IL-10 by monocytes and B cells has been documented both in patients with SLE and in their unaffected relatives (275). More recently, high innate IL-10 production was also found in family members of patients with SLE, but not CCLE (276).…”