Dysregulation of glucose metabolism even in Chinese PCOS women with normal glucose tolerance

Abstract

Polycystic ovary syndrome (Pcos) is the most common endocrine disturbance in women of reproductive age [1]. It is important to prevent glucose metabolic disorder of PCOS as early as possible since more than 40% of PCOS women might develop impaired glucose tolerance or type 2 diabetes [2,3]. However, the early interventions of improving glucose metabolism were seldom adopted because the glucose levels of PCOS women were normal before developing impaired glucose tolerance.Insulin resistance is a common feature of PCOS [4][5][6], and when insulin secretion from β cell becomes inadequate in relation to insulin resistance, impaired glucose tolerance and type 2 diabetes will eventually develop [7,8]. However, few studies investigated glucose levels distribution of PCOS before developing impaired glu- In conclusion, insulin resistance and dysregulation of glucose metabolism were common in Chinese PCOS women with normal glucose tolerance. BMI ≥ 25.545kg/m 2 indicated impaired β cell function in PCOS women with normal glucose tolerance.Key words: Polycystic ovary syndrome, β cell function, Insulin resistance, Normal glucose tolerance cose tolerance and the association between β cell function and PCOS is still disputable. Especially for PCOS women with normal glucose tolerance, lots of studies (in particular from North American) found impaired β cell function [4,8,9], while other studies reported preserved β cell function [7,10,11]. The difference of β cell function in previous studies might be related to failing to take into account the effect of confounding variables, such as ethnicity [12], medication history [13], a family history of type 2 diabetes [14]. In addition, the methods of evaluating β cell function could vary between different studies, with important consequences on metabolic results.To clarify the necessity of preventing glucose metabolic disorder of PCOS as early as possible and to understand why PCOS women with normal glucose tolerance show such heterogeneous levels of β cell function, the present study investigated glucose levels distribution, insulin sensitivity by euglycemic-hyperinsulinemic clamp and β cell function by homeostatic model assessment (HOMA)-β index after adjusting insulin sensitivity (HOMA-βad index) in Chinese PCOS women with normal glucose tolerance after excluding the effect of

Association between red blood cell distribution width and polycystic ovary syndrome

“…Overall, insulin resistance and the compensatory hyperinsulinemia affect 50-70% of women with PCOS (4,5). PCOS is associated with a higher prevalence of chronic low-grade inflammation, dyslipidemia, hypertension, obesity, impaired glucose tolerance, metabolic syndrome, diabetes and cardiovascular risk factors (6)(7)(8).…”

Comparison of Insulin Sensitivity Levels in Women with PCOS and Women with Regular Menses

“…PKOS 'dan etkilenen kadınlar kronik düşük dereceli inflamasyon, dislipidemi, hipertansiyon, obesite, bozulmuş glukoz toleransı metabolik sendrom diabet ve kardiyovasküler hastalıkların artmış riski ile birliktelik gös-terir 11,12 . Bu çalışmada olduğu gibi PKOS'lu kadınların açlık glukoz değerleri coğu zaman normal sınırlarda olmasına rağmen; glukoz intoleransına eğilimli oldukları bilinmektedir.…”

“…Bu metabolik yüke bir de vücut yağ kitlesi fazlalığı olarak bilinen obezitenin eklenmesi bu sendromdan etkilenen kadınların glukoz metabolizmasının daha da fazla bozulmasına yol açar. Hatta zayıf PKOS'lu kadınlardaki insülin duyarlılığındaki azalma seviyesinin PKOS'u olmayan obes kadınlarakine benzer derecede olduğu bildirilmiştir [11][12][13] . Androjen fazlalığı cemiyeti obez PKOS'luların zayıf PKOS'lulara kıyasla tip 2 diabetes mellitus gelişim riskinin daha fazla olmasından ötürü obes PKOS'lularda olası bozulmuş glukoz toleransı veya tip 2 diabetes mellitus varlığının incelenmesi amacı ile 2 saatlik glukoz yükleme testinin rutin olarak uygulanmasını önermektedir 14 .…”

“…ve genç (ortalama yaş sağlıklı grup: 25,14±6,044 yıl; PKOS=23,1±7,031 yıl) kadın-lardan meydana gelmesi olabilir. Ayrıca sigara kullanımı gibi insülin direncini artıran bağımsız değişkenlerin ça-lışma grubuna dahil edilmemesi de bu durumu etkilemiş olabilir 12,19 . Dolayısı ile kıyaslanan çalışmalardaki sonuç-lar sadece incelenen kadınların ait olduğu spesifik popülasyon için geçerli olabilir.…”

Insulin resistance according to β-cell function in women with polycystic ovary syndrome and normal glucose tolerance

“…IR is recognized as a major risk factor for the development of type 2 diabetes mellitus (T2DM), which is 5-to 10-fold higher in women with PCOS than in healthy controls [2]. A previous study showed that Chinese women with PCOS and normal glucose tolerance had higher IR than controls, even in lean subjects [3]. However, few studies have investigated IR in women with PCOS and normal glucose tolerance, especially in lean women with PCOS.…”