Association between red blood cell distribution width and polycystic ovary syndrome

Yılmaz, Özgür; Calan, Mehmet; Kelekçi, Sefa; Temür, Muzaffer

doi:10.3109/07435800.2014.987398

Cited by 11 publications

(13 citation statements)

References 28 publications

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“… 4 Unlike our findings, a significantly higher RDW (another inflammatory marker) was reported in women in the PCOS group compared with the control group. 4 …”

Section: Discussioncontrasting

confidence: 99%

Peripheral hematological parameters in women with polycystic ovary syndrome

ALhabardi

Al‐Wutayd

Eltayieb³

et al. 2020

J Int Med Res

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Objective There have been few studies on hematological parameters (e.g., hemoglobin, red cell distribution width, white blood cells, and mean platelet volume), and polycystic ovary syndrome (PCOS). This study aimed to compare hematological parameters between women with PCOS and controls. Methods We performed an age-matched case–control study in Faisal bin Mishal Center for Infertility, Buraidah (Kingdom of Saudi Arabia). The cases were women with PCOS and an equal number of healthy women were enrolled as controls. The basic gynecological history was recorded and blood samples were analyzed for blood parameters using an automated hematology analyzer. Results The two groups (60 women in each arm of the study) were similar in age. However, body mass index was significantly higher in women with PCOs compared with controls. There were no significant differences in any of the hematological parameters (hemoglobin, red blood cells, red cell distribution width, white blood cells, platelets, and mean platelet volume) between the two groups. Conclusion There does not appear to be a significant difference in hematological parameters in Saudi women with PCOS and healthy controls. A larger study on this issue is required in the future.

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“… 4 Unlike our findings, a significantly higher RDW (another inflammatory marker) was reported in women in the PCOS group compared with the control group. 4 …”

Section: Discussioncontrasting

confidence: 99%

Peripheral hematological parameters in women with polycystic ovary syndrome

ALhabardi

Al‐Wutayd

Eltayieb³

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Moreover, a number of studies have reported a correlation in decreased MCV with inflammation markers in patients with inflammatory bowel disease [28,29]. The findings of this study showed a direct association between WC and RDW, which is in line with previous studies that reported significantly higher mean platelet volume and RDW in patients with adiposity related MetS compared to those without MetS or positively correlated with high-sensitive CRP, HOMA insulin resistance and BMI [30,31].…”

Section: Discussionsupporting

confidence: 91%

A structural equation model to assess the pathways of body adiposity and inflammation status on dysmetabolic biomarkers via red cell distribution width and mean corpuscular volume: a cross-sectional study in overweight and obese subjects

et al. 2020

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Background: A study has been performed in overweight and obese subjects to assess the effects of adiposity and inflammation indicators on dysmetabolic biomarkers via red cell distribution width (RDW) and mean corpuscular volume (MCV), taking into account pro-antioxidant balance. Methods: Data from 166 overweight subjects were analyzed by a path analysis model using structural equation modelling (SEM) to evaluate the direct and indirect pathway effects of adiposity, measured by body mass index (BMI) and waist circumference (WC), and inflammation status, measured by pro-antioxidant balance [reactive oxygen species (ROS)], lag-time and slope and C-reactive protein (CRP) values on dysmetabolic biomarkers, via RDW and MCV. Results: BMI was strongly linked to CRP and ROS levels. Moreover, there was a significant negative decrease of MCV (1.546 femtoliters) linked to BMI indirectly via high CRP levels. Furthermore, WC affected RDW, indicating a possible mediatory role for RDW in relation to the relationship between WC and homeostatic model assessment (HOMA), insulin and high density lipoprotein (HDL), respectively. This was evident by the elevated HOMA and insulin levels and the decreased levels of HDL. Finally, ROS-related markers did not affect directly RDW and MCV.

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“…In the past several years, RDW has received the attention in the field of inflammation inasmuch as it was associated with the presences and outcomes in patients with polycystic ovary syndrome, ankylosing spondylitis, myocardial infarction, acute pancreatitis-associated lung injury, and spontaneous echo contrast. 4 – 8 Magnetic resonance imaging (MRI), as a expensive checking method, is clinically a valuation methodology of brain or spinal cord disease activity of MS. 9 It has been previously observed that the pathogenesis of MS is associated with inflammatory factors, and found that pro-inflammatory cytokines increase in patients with MS such as tumor necrosis factor (TNF) and interleukin-1β (IL-1β). 10 – 11 It is then noteworthy that loss of polyunsaturated fatty acids from plasma and blood cell membranes is observed in patients with MS, 12 which contributes to the variation of erythrocyte deformability.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Relationship Between Red Cell Distribution Width and Multiple Sclerosis

et al. 2015

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Accumulating data have shown that immune and inflammatory factors are involved in the pathogenesis of multiple sclerosis (MS), and loss of polyunsaturated fatty acids from plasma and blood cell membranes has also been reported in patients with MS, contributing to the variation of erythrocyte deformability. Therefore, the aim of this investigation was to assess the association between red blood cell distribution width (RDW) and MS.A total of 109 patients with MS and 130 healthy individuals were enrolled into the study, and MS patients receiving treatment of subcutaneous recombinant Rebif (IFN-β1a) were followed retrospectively. Complete blood cell counts and Expanded Disability Status Scale (EDSS) score were evaluated in patients with MS before and after treatment.RDW values were significantly higher in patients with MS compared with the controls (13.6 ± 0.89 vs 12.8 ± 0.38, P < 0.001); a positive correlation between RDW and EDSS score was observed in patients with MS (r = 0.789, P < 0.001). Significant differences in the value of RDW and EDSS score were observed between treatment-naive patients and treated patients (13.6 ± 0.95 vs 12.7 ± 0.44, P < 0.001; 3.6 ± 1.39 vs 1.5 ± 0.60, P < 0.001). RDW was associated independently with MS in logistic regression analysis (odds ratio = 7.007; 95% confidence interval [CI] 3.461–14.187; P < 0.001), and receiver-operating characteristics (ROC) analysis showed that a RDW measurement >13.11% evaluated MS with a sensitivity of 70.0% and a specificity of 84.7%, and the area under the ROC curve for RDW was calculated as 0.80 (95% CI 0.739–0.859, P < 0.001). The level of RDW was decreased in treatment responders with the reduction of EDSS score; a strong relationship was also observed in treatment responders between RDW and EDSS score (r = 0.733, P < 0.001), and covariance analysis indicated RDW values decreased significantly in treatment responders (P = 0.025).Our results suggest that elevated RDW values are associated with EDSS score in patients with MS, and the relationship is remarkably influenced by Rebif treatment; RDW may be a useful marker to estimate disability status and treatment effectiveness in patients with MS.

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Association between red blood cell distribution width and polycystic ovary syndrome

Abstract: RDW levels were higher in women with PCOS, and high-RDW levels were independently associated with PCOS. This link in between RDW and PCOS may be due to an underlying chronic inflammation in subjects with PCOS.

Cited by 11 publications

References 28 publications

Peripheral hematological parameters in women with polycystic ovary syndrome

Peripheral hematological parameters in women with polycystic ovary syndrome

A structural equation model to assess the pathways of body adiposity and inflammation status on dysmetabolic biomarkers via red cell distribution width and mean corpuscular volume: a cross-sectional study in overweight and obese subjects

Assessment of the Relationship Between Red Cell Distribution Width and Multiple Sclerosis

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