Dysregulated microRNA expression in IL-4 transgenic mice, an animal model of atopic dermatitis

Bao, Lei; Chau, C.; Lei, Zhengdeng; Hu, Hong Ming; Chan, Angelina G; Amber, Kyle T.; Maienschein‐Cline, Mark; Tsoukas, Maria M.

doi:10.1007/s00403-020-02176-w

Cited by 4 publications

(1 citation statement)

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“…The miRNAs mediate post-transcriptional silencing through partial complementary binding to the 3′un-translated region (UTR) of the target mRNA. Decreased expression of some miRNAs has been observed in immune-mediated inflammatory skin lesions including OLP [ 192 , 193 , 194 ] psoriasis [ 194 , 195 , 196 ], and atopic eczema [ 197 , 198 , 199 , 200 , 201 ] compared to healthy non-lesional skin. In OLP, Wang et al employed HaCaT keratinocytes stimulated with lipopolysaccharide (LPS) to mimic the OLP immune environment and examined, under OLP-like settings, the role of miR-125b in the growth and apoptosis of keratinocytes.…”

Section: Role Of the Pi3k-akt-mtor And Related Network In Skin Develo...mentioning

confidence: 99%

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Roy

Boateng

Uddin

et al. 2023

Cells

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The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, and vitiligo, and is associated with poor treatment outcomes. Improved comprehension of the consequences of the dysregulated PI3K/Akt/mTOR pathway in patients with inflammatory dermatoses has resulted in the development of novel therapeutic approaches. Nonetheless, more studies are necessary to validate the regulatory role of this pathway and to create more effective preventive and treatment methods for a wide range of inflammatory skin diseases. Several studies have revealed that certain natural products and synthetic compounds can obstruct the expression/activity of PI3K/Akt/mTOR, underscoring their potential in managing common and persistent skin inflammatory disorders. This review summarizes recent advances in understanding the role of the activated PI3K/Akt/mTOR pathway and associated components in immune-mediated inflammatory dermatoses and discusses the potential of bioactive natural products, synthetic scaffolds, and biologic agents in their prevention and treatment. However, further research is necessary to validate the regulatory role of this pathway and develop more effective therapies for inflammatory skin disorders.

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