Cytokines and Chemokines Modulation of Itch

Du, Lixia; Zhu, Jianyu; Mi, Wen-Li

doi:10.1016/j.neuroscience.2022.05.035

Cited by 12 publications

(10 citation statements)

References 134 publications

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“…By participating in the activation of T lymphocytes, neutrophils and macrophages as well as their recruitment to the site of inflammation, chemokines seem to play a significant role in the pathogenesis of chronic inflammatory skin diseases, such as PsO [ 13 , 14 ]. Moreover, it is postulated that chemokines may also be involved in the aetiology of pruritus [ 15 ]. However, their impact on the development of PsO and the associated pruritus has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Purzycka-Bohdan

Nedoszytko

Zabłotna

et al. 2022

IJMS

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Psoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play a significant role in PsO pathogenesis. The aim of the study was to analyse serum concentrations of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC, CCL18/PARC, CCL22/MDC and CXCL8/IL-8, and their correlation with PsO severity and pruritus intensity. The study included 60 PsO patients and 40 healthy volunteers. Serum concentrations of six (CCL2/MCP-1, CCL3/MIP-1α, CCL5/RANTES, CCL17/TARC, CCL18/PARC and CCL22/MDC) out of eight analysed chemokines were significantly elevated in PsO patients; however, they did not correlate with disease severity. The serum level of CCL5/RANTES was significantly higher in patients with the psoriasis area and severity index (PASI) ≥ 15 (p = 0.01). The serum concentration of CCL17/TARC correlated positively with pruritus assessed using the visual analogue scale (VAS) (R = 0.47; p = 0.05). The study indicated CCL17/TARC as a potential biomarker of pruritus intensity in PsO patients. Chemokines appear to be involved in the development of PsO systemic inflammation. Further detailed studies on the interactions between chemokines, proinflammatory cytokines and immune system cells in PsO are required to search for new targeted therapies.

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Section: Introductionmentioning

confidence: 99%

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Purzycka-Bohdan

Nedoszytko

Zabłotna

et al. 2022

IJMS

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“…96 For example, IL-4 receptor monoclonal antibody dupilumab, IL-17 monoclonal antibody adalimumab, JAK inhibitor upadacitinib, and IL-31 inhibitor nemolizumab are currently in use and under development for the treatment of chronic pruritic skin conditions. 63 However, the contributions of glial cells in relieving itch with these biological agents are not yet clear. There are thus far no clinically approved drugs that selectively target glial cells to relieve itch, but drug discovery efforts are currently in progress.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, many new drugs that act as inhibitors or neutralizing antibodies against glia-cell-released cytokines and chemokines are being investigated, and some have been approved for the treatment of chronic pruritic conditions . For example, IL-4 receptor monoclonal antibody dupilumab, IL-17 monoclonal antibody adalimumab, JAK inhibitor upadacitinib, and IL-31 inhibitor nemolizumab are currently in use and under development for the treatment of chronic pruritic skin conditions . However, the contributions of glial cells in relieving itch with these biological agents are not yet clear.…”

Section: Discussionmentioning

confidence: 99%

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Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies

Gao

Wang

2023

ACS Chem. Neurosci.

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Glial cells, which are the non-neuronal cells of the nervous system, play essential roles in brain development, homeostasis, and diseases. Glial cells have attracted attention because of their active involvement in many neurological disorders. In recent years, substantial progress has been made in our understanding of the roles of glial cells in the pathogenesis of itch. Mechanistically, central and peripheral glial cells modulate acute and chronic pruritus via different mechanisms. In this review, we present the current knowledge about the involvement of glial cells in the modulation of itch processing and the mechanism of glial cell activation under itch stimuli. Targeting glial cells may provide novel approaches for itch therapy.

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“…Moreover, itch was observed in 97.2% of our CI cohort, and JAK inhibitors to date have proved successful in reducing itch [42]. Another common driver of itch, IL-13 [43], was elevated for IV, EI, and TTD patients (P2 and P3), suggesting that the atopic dermatitis biologic tralokinumab, an IL-13 inhibitor, might prove useful in reducing itch and inflammation in some CI patients [44], or alternatively, the IL-4/IL-13 inhibitor dupilumab. Ultimately, the dysbiosis clustering described here suggests that optimized treatment regimens for CI types will have to account for their heterogeneity from a genetic, microbiome, and immunological viewpoint.…”

Section: Discussionmentioning

confidence: 99%

Altered skin microbiome, inflammation, and JAK/STAT signaling in Southeast Asian ichthyosis patients

Huynh

Hoang

et al. 2022

Preprint

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Cutaneous ichthyosis (CI) is a collective group of monogenetic disorders of cornification demonstrating epidermal scaling, fissuring, chronic skin inflammation, and increased susceptibility to infection. In healthy individuals the skin microbiome limits growth of pathogenic organisms; however, the microbiome signature in CI is poorly characterized. To rectify this, we investigated the microbiome signature across 7 subtypes of CI in 43 individuals of Southeast Asian ethnicity, of which exome sequencing revealed 20 novel and 31 recurrent pathogenic variants. Microbiome meta-analysis revealed distinct microbial populations, reduced commensal microbiota, and higher colonization by pathogenic species. This correlated with increased production of inflammatory cytokines, including Th17 and JAK/STAT signaling, in peripheral blood mononuclear cells. Moreover, we identified microbiota and inflammation alterations in wounds of CI patients responsible for impaired wound healing. Together, this research enhances our understanding of the microbiological, immunological, and molecular properties of CI patients and provides critical information for improving therapeutic management.

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Cytokines and Chemokines Modulation of Itch

Cited by 12 publications

References 134 publications

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus

Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies

Altered skin microbiome, inflammation, and JAK/STAT signaling in Southeast Asian ichthyosis patients

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