Dysregulated lipid metabolism in cancer

Zhang, Feng; Du, Guangwei

doi:10.4331/wjbc.v3.i8.167

Cited by 196 publications

(191 citation statements)

References 75 publications

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“…Many of these effects could involve changes in membrane phospholipid composition. Alterations of lipid metabolism have been reported to be a common property of malignant cells (Fritz & Fajas 2010;Zhang & Du 2012). In that sense, increased de novo synthesis has been associated with development of malignancies (Medes et al 1953;Kuhajda 2000).…”

Section: Resultsmentioning

confidence: 99%

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Influence of environmental medium on membrane fatty acid composition of Reuber H35 hepatoma cells

García-Pelayo

Garcia-Peregrin

Martínez-Cayuela

2013

Frontiers in Life Science

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Cell membrane proteins are sensitive to their fatty acid environment; however, the effects of those fatty acids are not completely understood. In this work, we have optimized a model for the study of membrane protein regulation, which allows the investigation of lipid metabolism in cultured tumor cells. The membrane fatty acid composition of Reuber H35 hepatoma cells was modified by enriching phospholipids in individual fatty acids of different length and degree of saturation. Lauric, myristic, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were supplemented to the culture medium of cells growing in presence or absence of lipoproteins. The four fatty acids were incorporated into membrane phospholipids in a dosedependent manner. Lauric and myristic acids were actively metabolized, increasing percentages of longer and unsaturated chain fatty acids, but they did not modify the unsaturated index. As expected, EPA and DHA significantly decreased the unsaturated index. Incorporation of EPA and DHA was accompanied of a significant decrease of total monounsaturated fatty acids and an increase of total saturated fatty acids. Our results demonstrate that Reuber H35 hepatoma cells constitute a suitable model to manipulate the lipid composition of the cell membranes and perform functionality studies on the membrane proteins in response to their lipid environment.

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Section: Resultsmentioning

confidence: 99%

“…There is evidence to support that membrane fatty acid composition in cancer cells plays a key role in modulating different aspects of cell metabolism, many of them related to cell proliferation (Fritz & Fajas 2010;Rysman et al 2010;Zhang & Du 2012).…”

Section: Introductionmentioning

confidence: 99%

Influence of environmental medium on membrane fatty acid composition of Reuber H35 hepatoma cells

García-Pelayo

Garcia-Peregrin

Martínez-Cayuela

2013

Frontiers in Life Science

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“…In addition to enhanced glucose and glutamine metabolism, alterations in cancer cell fatty acid (FA) metabolism have been reported (Balaban et al ., 2015). However, in general, these observations have predominantly been limited to the synthesis of new FAs from nonlipid carbon sources, that is, glucose and glutamine (Zhang and Du, 2012). One important observation is that FAs contributed more to total ATP turnover in breast cancer (BrCa) cells than that of glucose or glutamine (Guppy et al ., 2002).…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis

et al. 2018

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Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alters MCF‐7 and MDA‐MB‐231 cell metabolism and promotes proliferation and migration. Since adipocytes are FA‐rich, and these FAs are transferred to BrCa cells, we sought to elucidate the FA metabolism of BrCa cells and their response to FA‐rich environments. MCF‐7 and MDA‐MB‐231 cells incubated in serum‐containing media supplemented with FAs accumulate extracellular FAs as intracellular triacylglycerols (TAG) in a dose‐dependent manner, with MDA‐MB‐231 cells accumulating more TAG. The differences in TAG levels were a consequence of distinct differences in intracellular partitioning of FAs, and not due to differences in the rate of FA uptake. Specifically, MCF‐7 cells preferentially partition FAs into mitochondrial oxidation, whereas MDA‐MB‐231 cells partition FAs into TAG synthesis. These differences in intracellular FA handling underpin differences in the sensitivity to palmitate‐induced lipotoxicity, with MDA‐MB‐231 cells being highly sensitive, whereas MCF‐7 cells are partially protected. The attenuation of palmitate‐induced lipotoxicity in MCF‐7 cells was reversed by inhibition of FA oxidation. Pretreatment of MDA‐MB‐231 cells with FAs increased TAG synthesis and reduced palmitate‐induced apoptosis. Our results provide novel insight into the potential influences of obesity on BrCa biology, highlighting distinct differences in FA metabolism in MCF‐7 and MDA‐MB‐231 cells and how lipid‐rich environments modulate these effects.

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“…Cutaneous melanocytes, from the dermicepidermic junction, lay in a low oxygen medium [16,17]. Tissue hypoxia can modify cellular behavior by direct influence on: cell cycle, cellular metabolism, differentiation, proliferation and survival, degradation and remodeling of extracellular matrix, tumor migration, invasion and metastasis, angiogenesis, apoptosis, cells sensitivity to antitumor therapy (Table 1) [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Cells ability to adapt to hypoxia is mediated by several transcription factors.…”

Section: Introductionmentioning

confidence: 99%

“…Its expression and tissue distribution are influnenced by many factors [3,[30][31][32][33][34][35][36][37][38]: modulators of cellular degradation (EPF, UCP, VDU2, Sumoylation, DeSUMOylation, Prolyl hydroxylases, PVLH, OS-9, SSAT 1, SSAT 2, GSK3 beta, Table 1. Representative target genes of Hypoxia-Inducible Factor1 (HIF1) and their functions [17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%