Dysregulated Epstein-Barr virus infection in patients with CIDP

Abstract

Ubiquitous viruses have frequently been proposed as a cause or trigger of chronic immune-mediated diseases. Infections are reported to be temporally associated with clinical exacerbations in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined immunological parameters of herpesvirus infections in untreated patients with CIDP compared to demographically matched controls. Patients with CIDP were uniformly seropositive for EBV-specific IgG and the disease was associated with a moderately enhanced IgG reactivity to EBV-encoded antigens expressed during both B cell transformation and productive viral replication. Moreover, cellular EBV copy numbers were 3-fold increased in patients with CIDP. In contrast, humoral immune responses to other herpesviruses (HCMV, HSV) as well as virus-specific IgM responses were unchanged in CIDP. These data indicate that host-pathogen interactions during chronic EBV infection are dysregulated in treatment-naïve patients with CIDP. Dysregulated Epstein-Barr Virus Infection in Patients with CIDP

Recovery of the T-cell repertoire in CIDP by IV immunoglobulins

“…[17][18][19][20] Together with our findings, these studies point toward an important pathophysiologic role of T cells in the development of CIDP. In CIDP, a higher Epstein-Barr virus (EBV) copy number as well as moderately enhanced EBV-specific IgG could be demonstrated by Lünemann et al 23 The term "public expansion" describes that identical TCR length increases are detected in different individuals. The tendency of oligoclonal activations has been discussed to represent a chronic T-cell response to infections.…”

Drug‐induced hypersensitivity syndrome followed by chronic inflammatory demyelinating polyneuropathy

“…3 CMV or EBV reactivation has also been reported in patients with CIDP. 4,5 Although the detailed mechanism is unclear, CMV reactivation might have been associated with the development of subsequent CIDP in our case.…”

Herpesvirus-associated central and peripheral nervous system involvement: two clinical cases

“…Особый вклад в развитие ХВДП вносит ВЭБ [18,19]. Пре-имущественно сенсорный вариант ХВДП составляет до 50% криптогенных полиневропатий, встречающихся на этапе первичного звена здравоохранения [20].…”