Dysphagia in Stroke, Neurodegenerative Disease, and Advanced Dementia

Altman, Kenneth W.; Richards, Amanda L.; Goldberg, Leanne; McCabe, Daniel J.

doi:10.1016/j.otc.2013.08.005

Cited by 54 publications

(33 citation statements)

References 45 publications

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“…Summarize patient response rates and completeness of data collection 11. Clarify what follow-up, if any, was expected and the percentage of patients for which incomplete data or follow-up was obtained Neurol Sci eliminated two studies [24,25] after consulting the original author; three papers included unspecified Multiple Sclerosis [26][27][28]; two papers which one study contained only relapsing remitting MS patients and another only recruited primary progressive and secondary progressive patients were also excluded [4,9].…”

Section: Literature Searchmentioning

confidence: 99%

Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis

et al. 2015

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Although dysphagia was recognized as a clinical finding in multiple sclerosis (MS) as early as 1877, it has not received enough attention yet. With the progress of diagnostic method for dysphagia, there has been a rapid development in estimating the prevalence of deglutition disorder in MS. In this review, we aimed to conduct a systematic review and meta-analysis of published literature to establish the prevalence of dysphagia in multiple sclerosis. We systematically searched Embase, PubMed databases and Cochrane library from 1980 to August 2014, supplemented by hand searching to identify relevant studies. We used random-effects model to calculate pooled prevalence. Potential sources of heterogeneity were explored using sensitivity test and subgroup analysis, meta-regression analysis. Of 198 retrieved articles, 15 eligible surveys with a total population of 4,510 met the criteria. Twelve studies provided an estimate based on subjective screening test, which proved substantial heterogeneity (Cochran's χ(2) significant at p < 0.0001; I(2) = 92.4 %, 95 % CI 31-42 %), with a combined prevalence estimate of 36 %. Four studies provided an estimate based on objective measurements (clinical or instrument tools), which were substantial heterogeneity (Cochran's χ(2) significant at p < 0.005; I(2) = 77 %, 95 % CI 67-94 %), with a pooled prevalence estimate of 81 %. A large heterogeneity still existed after conducting several subgroup analyses and sensitivity tests. The findings confirm that more than one-third of the multiple sclerosis patients are suffering from swallowing difficulties. Therefore, we should be careful to interpret the pooled estimate due to the substantial heterogeneity between studies.

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Section: Literature Searchmentioning

confidence: 99%

Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis

et al. 2015

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“…Feeding-related disorders and symptoms, particularly impaired mastication and swallowing (i.e., dysphagia) as a result of aging [1] and major neurological disorders [2, 3] such as cerebral vascular accident [4], Parkinson’s disease [5], and amyotrophic lateral sclerosis (ALS) [6] have become significant societal burdens; indeed, one in 17 people will develop some form of dysphagia in their life time [7]. Human experimentation has greatly advanced our knowledge of human feeding physiology and pathophysiology but human research is constrained by limits on human exposure to the ionizing radiation associated with videofluoroscopic studies of hyolingual kinematics.…”

Section: Introductionmentioning

confidence: 99%

Sagittal Plane Kinematics of the Jaw and Hyolingual Apparatus During Swallowing in Macaca mulatta

et al. 2017

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Studies of mechanisms of feeding behavior are important in a society where aging- and disease-related feeding disorders are increasingly prevalent. It is important to evaluate the clinical relevance of animal models of the disease and the control. Our present study quantifies macaque hyolingual and jaw kinematics around swallowing cycles to determine the extent to which macaque swallowing resembles that of humans. One female and one male adult Macaca mulatta were trained to feed in a primate chair. Videofluoroscopy was used to record kinematics in a sagittal view during natural feeding on solid food, and the kinematics of the hyoid bone, thyroid cartilage, mandibular jaw, and anterior-, middle-, and posterior-tongue. Jaw gape cycles were defined by consecutive maximum gapes, and the kinematics of the swallow cycles were compared with those of the two consecutive non-swallow cycles preceding and succeeding the swallow cycles. Although there are size differences between macaques and humans, and macaques have shorter durations of jaw gape cycles and hyoid and thyroid upward movements, there are several important similarities between our macaque data and human data reported in the literature: (1) The durations of jaw gape cycles during swallow cycles are longer than those of non-swallow cycles as a result of an increased duration of the jaw-opening phase; (2) Hyoid and thyroid upward movement is linked with a posterior tongue movement and is faster during swallow than non-swallow cycles; (3) Tongue elevation propagates from anterior to posterior during swallow and non-swallow cycles. These findings suggest that macaques can be a useful experimental model for human swallowing studies.

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“…49 Er zijn op dit moment in Nederland ongeveer 260.000 mensen met een vorm van dementie (dus in België en Nederland samen ca. 430.000).…”

Section: Dementiesyndromenunclassified

“…28 Ook sondevoeding kan worden ingezet, maar er zijn aanwijzingen dat het gebruik ervan bij dementiepatiënten in de eindfase van de ziekte geen aspiratie voorkomt en niet levensverlengend is. 11,49 Conclusie en discussie Slikstoornissen bij neurodegeneratieve aandoeningen komen veel voor en zullen door de verwachte toename van het aantal patiënten in de toekomst ook meer aandacht vragen van met name neurologen, specialist ouderengeneeskundigen, geriaters, verpleegkundigen en verzorgenden, logopedisten en diëtisten. De meerwaarde van interventies is echter onvoldoende onderzocht en verspreid.…”

Section: Behandeling Van Slikstoornissen Bij Dementieunclassified

Orofaryngeale slikstoornissen bij neurodegeneratieve aandoeningen

Kalf

Wit²

2014

Tijdschr Gerontol Geriatr

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Neurodegenerative diseases are progressive degenerations of the brain with increasing movement disorders, like gait, speech and swallowing disorders combined with cognitive disorders, like dementia. Neurodegenerative diseases have in common that aspiration pneumonia is the most frequent cause of death in the end-stage of the disease. This article provides an overview of the prevalence, characteristics and treatments of oropharyngeal dysphagia resulting from multiple system atrophy (MSA), progressive supranuclear palsy (PSP), Huntington's disease (HD), multiple sclerosis (MS) and dementia. The prevalence of dysphagia ranges from 32% in MS, 57% in patients with dementia to 73% in patients with MSA and almost 100% in patients with PSP or HD. Treatment is aimed at swallowing with less effort, swallowing more safely and/or optimal nutritional intake. When cognitive decline and behavioural changes increase, passive compensations like food adaptations and comfortable mealtime conditions become the principal interventions.

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Dysphagia in Stroke, Neurodegenerative Disease, and Advanced Dementia

Cited by 54 publications

References 45 publications

Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis

Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis

Sagittal Plane Kinematics of the Jaw and Hyolingual Apparatus During Swallowing in Macaca mulatta

Orofaryngeale slikstoornissen bij neurodegeneratieve aandoeningen

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