Dysphagia in Bouviers associated with muscular dystrophy; evaluation of 24 cases

Me, Peeters; Aj, Venker-van Haagen; Sa, Goedegebuure; Wt, Wolvekamp

doi:10.1080/01652176.1991.9694287

Cited by 15 publications

(9 citation statements)

References 5 publications

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“…A case series 15,16 involving 24 Bouvier des Flandres with dysphagia reported that affected dogs had histologic evidence of progressive degeneration of the pharyngeal muscles, and the histologic and electromyographic findings in these Bouviers had some similarities to findings for dogs in the present report. The Bouviers were described as having muscular dystrophy, although results of immunohistochemical staining for muscular dystrophy proteins or lineages of infiltrating cells were not reported.…”

supporting

confidence: 76%

Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

Ryckman¹,

Krahwinkel²,

Sims³

et al. 2005

javma

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Two adult Boxers were evaluated because of chronic dysphagia of several years' duration. Serum creatine kinase activity was high in both dogs, but other hematologic or serum biochemical abnormalities were not detected. Esophagraphy revealed abnormalities of the cricopharyngeal phase of swallowing in both dogs, and electromyography of the pharyngeal and laryngeal muscles revealed complex repetitive discharges, positive sharp waves, and fibrillation potentials characteristic of primary myopathy or neuropathy. Because of the severity of their condition, both dogs were euthanatized. Histologically, mixed-cell infiltrates were seen in sections of the masseter and thyropharyngeal muscles. Results of indirect immunofluorescence staining for proteins associated with dystrophic myopathy were unremarkable, except for decreased staining for integrin alpha7. A diagnosis of chronic inflammatory myopathy was made. The clinical importance of reduced staining for integrin alpha7 could not be determined but was considered to be a result of the myopathy.

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supporting

confidence: 76%

Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

Ryckman¹,

Krahwinkel²,

Sims³

et al. 2005

javma

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“…A predisposition for the disease has been reported in large and giant-breed dogs such as the German shepherd, Great Dane, Irish setter, Labrador retriever, Irish wolfhound and Newfoundland (Knowles and others 1990), and genetics might play a role in the aetiology of CIM because autosomal dominant inheritance has been demonstrated in miniature Schnauzers and fox terriers (Washabau 2003). A suspected hereditary form has also been reported in Bouvier des Flandres dogs (Peeters and others 1991). …”

Section: Introductionmentioning

confidence: 88%

Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial

et al. 2017

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We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). The dogs were given sildenafil oral suspension 1 mg/kg every 12 hours for 14 days or placebo in a masked fashion. Clinical signs (frequency of regurgitation and weight gain) and oesophagrams (relative oesophageal diameter, ROD) were evaluated in order to assess the efficacy of drug treatment, by examiners who were unaware of the study protocol. In addition, a set of in vitro experiments on isolated samples of canine lower oesophageal sphincter (LOS) was performed, and the effects of increasing concentrations of sildenafil on basal tone and electrically-stimulated motility were assessed. Sildenafil administration significantly reduced the number of regurgitation episodes (0.88±1.40 v 2.65±1.56, P<0.0001) and significantly increased weight gain in the treated dogs compared to controls (79.76±28.30 per cent v 53.40±19.30 per cent, P=0.034). ROD values, at the end of the treatment period, were significantly decreased in the sildenafil group, compared to pre-treatment values (0.97±0.19 v 0.24±0.14, P<0.0001), in contrast to control subjects (0.98±0.17 v 1.10±0.25, P=0.480). In accordance with the in vivo findings, sildenafil dose-dependently reduced basal tone and increased electrically-induced relaxation of dog LOS samples. These results suggest that sildenafil citrate helps ameliorate clinical and radiographic signs in dogs with CIM by reducing LOS tone, and could represent a novel therapeutic tool for the treatment of this disease.

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“…Pharyngeal weakness is usually affiliated with neuromuscular diseases such as pseudorabies [87], myasthenia gravis [24], inflammatory myopathies [88, 89], congenital neurologic defects [90], and muscular dystrophy [91, 92]. It is also imperative to consider rabies in cases of pharyngeal weakness [87].…”

Section: Contrast Enhanced Videofluoroscopymentioning

confidence: 99%

“…In addition to reduced motility, contrast videofluoroscopy may identify irregularities of the esophageal mucosa with prolonged mucosal adherence of barium consistent with esophagitis [1]. Certain breeds appear to be predisposed to esophageal motility disorders including the Chinese Shar Pei, Bouvier des Flandres, and some breeds of terriers [91, 98, 101]. Additionally, redundancy of the esophagus has been reported as an incidental finding where gas and/or contrast material accumulates in a deviated section of the esophagus in the thoracic inlet region of young brachycephalic breeds [4].…”

Section: Contrast Enhanced Videofluoroscopymentioning

confidence: 99%

Imaging Evaluation of Dogs and Cats with Dysphagia

Pollard

2012

ISRN Veterinary Science

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Dysphagia in Bouviers associated with muscular dystrophy; evaluation of 24 cases

Cited by 15 publications

References 5 publications

Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

Dysphagia as the primary clinical abnormality in two dogs with inflammatory myopathy

Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial

Imaging Evaluation of Dogs and Cats with Dysphagia

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