Dysphagia and Unexpected Myasthenia Gravis Associated with Primary Biliary Cirrhosis, Ulcerative Colitis and Vitiligo

McCann, Peter; Pramanik, Abul Kasem

doi:10.1111/j.1532-5415.2004.52379_7.x

Cited by 14 publications

(7 citation statements)

References 4 publications

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“…An expected case was published at 2004 demonstrating the association of atypical myasthenia, manifesting by a dysphagia, to a PBC, an ulcerative colitis and a vitiligo [1].…”

Section: Discussionmentioning

confidence: 99%

“…Once the myasthenia gravis diagnosis is posed, an exhaustive research of autoimmune associated diseases is compulsory to have complete follow up of the patient [1]. We report the case of a 64-year-old man presenting an autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) or an overlap syndrome concomitant with unexpected myasthenia gravis and thymoma.…”

Section: Introductionmentioning

confidence: 99%

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Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Mahfoudhi¹,

Mamlouk²,

Turki³

et al. 2015

OJCD

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The myasthenia gravis is an autoimmune disease which can be associated frequently with a thymoma and also with autoimmune pathologies. We report the case of a 64-year-old man affected an overlap syndrome corresponding to the association of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). He also presented concomitant myasthenia gravis and thymoma. The physical examination notes only a disturbed voice. The liver tests showed: alkaline phosphatase 600 U/l, alanine aminotransferase 1280 U/l, and aspartate aminotransferase 985 U/l. Viral serologies of hepatitis were all negative, as well as antinuclear, antimitochondrial and antismooth muscle antibodies. The diagnosis of an overlap syndrome was posed according to the biological and hepatic histhological results. An associated myasthenia was confirmed by the results of the EMG and the positivity of the anti-acetylcholine receptor antibody. A chest CT revealed a thymoma. The treatment consisted of ursodeoxycholic acid, prednisone, azathioprine and pyridostigmine. And the patient improved his voice and the liver function. Thymectomy was practiced without incidents.

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“…An expected case was published at 2004 demonstrating the association of atypical myasthenia, manifesting by a dysphagia, to a PBC, an ulcerative colitis and a vitiligo [1].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Mahfoudhi¹,

Mamlouk²,

Turki³

et al. 2015

OJCD

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“…Our systematic literature review disclosed 15 papers and 21 patients with IBD and MG (Tables 1 and 2) [5,[7][8][9][10][11][12][14][15][16][17][18][19][20][21]. Sex and age were not detailed in some papers.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Galbraith et al reported a patient with MG who later developed ulcerative colitis (UC) and systemic lupus erythematosus [7], and other cases of MG with IBD have been reported [7][8][9][10][11][12], with MG being diagnosed both before and after IBD. Here, we present the clinical and electrodiagnostic findings of 2 patients with IBD who developed MG, from an IBD cohort that was established in 2004, and conducted a systematic literature review about the subject [3].…”

Section: Introductionmentioning

confidence: 99%

Two patients with co-morbid myasthenia gravis in a Brazilian cohort of inflammatory bowel disease

Gondim

Oliveira

Araújo

et al. 2014

Neuromuscular Disorders

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“…Although the development of extra intestinal manifestations during the course of IBD is well known, a controlled study indicated that 6.6% of UC patients and 1.9% of CD patients had at least 1 autoimmune disorder [5]. Cases of concomitant PBC and IBD are uncommon [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In addition, cases of concomitant PBC and CD appear to be extremely rare [21,22]; however, cases of concomitant PBC and UC have been sporadically reported [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Coexistence of Primary Biliary Cirrhosis and Inflammatory Bowel Disease

Shizuma¹

2014

J Liver

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The coexistence of Primary Biliary Cirrhosis (PBC) and Inflammatory Bowel Disease (IBD) is uncommon, although hepatobiliary complications in IBD patients are not rare. This report reviews the English and Japanese literature and covers reported cases of concomitant PBC and IBD. We identified 2 cases of concomitant PBC and Crohn's Disease (CD) and 18 cases of concomitant PBC and Ulcerative Colitis (UC). In most instances (15/18), IBD (CD or UC) developed before PBC, with the exception of 2 cases that were almost simultaneously diagnosed with both conditions. There is no evidence that UC cases with concomitant PBC are more severe than those without; however, the clinical features of concomitant PBC and CD are unclear due to few reports. J o u rn al of L iv e r

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Dysphagia and Unexpected Myasthenia Gravis Associated with Primary Biliary Cirrhosis, Ulcerative Colitis and Vitiligo

Cited by 14 publications

References 4 publications

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Two patients with co-morbid myasthenia gravis in a Brazilian cohort of inflammatory bowel disease

Coexistence of Primary Biliary Cirrhosis and Inflammatory Bowel Disease

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