Dysmenorrhea During Adolescence

Wïdholm, O

doi:10.3109/00016347909157792

Cited by 68 publications

(18 citation statements)

References 12 publications

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“…In approximately 10% of these dysmenorrheic subjects, the symptoms are disabling enough to cause incapacitation for one to two days a month (1)(2)(3)(4). Primary dysmenorrhea is the most common gynecologic complaint.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Çhan¹

1983

Annu. Rev. Pharmacol. Toxicol.

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INTRODUCTIONDysmenorrhea, commonly known as menstrual pain or cramps, is classifi ed into primary and secondary dysmenorrhea. Generally, primary dysmenorr hea has its inception at the onset of or soon after menarche and characteris tically has no identifiable macroscopical pathology. In contrast, secondary dysmenorrhea usually has its onset in adulthood and is associated with specific pelvic pathology. Some of the causes of secondary dysmenorrhea are endometriosis, uterine polyps, pelvic inflamm atory diseases, uterogeni tal anatomical anomaly, and intrauterine device. Primary dysmenorrhea is by far the more prevalent form.The incidence and prevalence of primary dysmenorrhea have not been established, but it has been estimated that as many as 50% of women of reproductive age, particularly nulliparas, suffer from dysmenorrhea at one time or other. In approximately 10% of these dysmenorrheic subjects, the symptoms are disabling enough to cause incapacitation for one to two days a month (1-4). Primary dysmenorrhea is the most common gynecologic complaint. Because of its cyclic recurring nature, the medical and socioeco nomic impact of dysmenorrhea is enormous. It is the greatest single cause of lost work hours and school days among women (5-8), with more than 140 million work hours estimated to be lost annually (4). With increasing numbers of women entering the work force, dysmenorrhea may cause an even greater economic loss to society. 131Annu. Rev. Pharmacol. Toxicol. 1983.23:131-149. Downloaded from www.annualreviews.org Access provided by University of California -Davis on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS 132 CHAN Despite the prevalence of dysmenorrhea, until very recently, medicine has made very little headway either toward the understanding of the patho physiology of dysmenorrhea or the discovery of a specifi c and effective therapy for this female malady. The introduction of oral contraceptives in the 19608 marked the advent of the first effective therapeutic agent for the treatment of primary dysmenorrhea. Oral contraceptives, however, are not specific agents for dysmenorrhea. Until that time, treatments for dys menorrhea were primarily symptomatic, involving strong analgesics, an tidepressants, alcohol, and a variety of home remedies. These therapeutic approaches have not been successful, because of either lack of efficacy or unacceptable side effects. The first rational therapy for dySmenorrhea ap peared on the medical scene as late as the mid 19708, when the relationship between prostaglandin (pG) and dysmenorrhea was recognized and the newer nonsteroidal anti-in1lamm atory drugs (NSAIDs) with PG synthetase inhibitory activity were being introduced to the general medical practice.This review focuses on the etiologic role of PO in primary dysmenorrhea and therapeutic suppression of uterine PG production as a specifi c therapy for dysmenorrhea. PATHOPHYSIOLOGY OF PRIMARY DYSMENORRHEAMany theories have been proposed for the cause of dysmenorrhea. These inc...

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Section: Introductionmentioning

confidence: 99%

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Çhan¹

1983

Annu. Rev. Pharmacol. Toxicol.

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“…Interdisciplinary research represented in the biopsychosocial model also has been recommended as a tool to investigate premenstrual syndrome (Abplanalp, 1980;Dennerstein, SpencerGardner, & Burrows, 1981;Clare, 1985;Txunnell, 1986;Wilson, 1990), a combination of timedelineated physical emotional and behavioral symptoms that occur before menstruation but after ovulation (luted phase), and regress or disappear during menstruation, not solely the result of environmental stress, the occur-JOURNAL OF HEALTH EDUCATION-NOVEMBEWDECEMBER 1992 (Delaney, Lupton, & Toth, 1976); societal milieuconveyscornplex negative meanings (McKeever, tially responsible for menstrual symptomatology (Aubuchont Calhoun, 1985) and premenstrual tension (Widholm, 1979). Because of this, it has been suggested that a woman has more than a biological clock to signal discomfort (Paige, 1973).…”

Section: Carola Wilson Isan Assistant Professor In the Skhool Ofhealmentioning

confidence: 96%

The Biopsychosocial Model: Menstrual Attitudes, Sources of Information, and Premenstrual Symptomatology among Mothers with and without PMS and Adolescent Daughters

Wilson

1992

Journal of Health Education

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“…Cer tain stud ies (Widholm, 1979;van den Akker et al, 1987) suggest that women whose mothe r s re por ted premenstrual tension were more likely (70% of daughters of affected mothers vs. 37% of daughters of unaffected mothers) to develop premenstrual mood symptoms. Also, concordance rates for symptoms of PMS are significantly higher in monozygotic twins (93%) compared to dizygotic twins (44%) or sibling controls (31%) (Dalton et al, 1987).…”

Section: Familial Factorsmentioning

confidence: 99%