Dyslipidemia in Subclinical Hypothyroidism: A Case-Control Study

Qasim, Bayar; Arif, Sardar Hassan; Mohammed, Ayad Ahmad; Abduljabbar, Rezvan

doi:10.15226/2374-6890/5/1/00192

Cited by 5 publications

(4 citation statements)

References 41 publications

(47 reference statements)

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“…A number of studies have reported that SCH is associated with increased risk of coronary heart diseases and results in significant increase in cluster of cardiometabolic risk factors. [13,14] Similar to earlier studies, we also found preponderance of cardiometabolic risk factors in subjects with SCH in comparison to euthyroid subjects. In subjects with SH, there is a significant increase in diastolic blood pressure, total, and LDL cholesterol as well as fasting blood sugar levels.…”

Section: Discussionsupporting

confidence: 90%

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Saha

Choudhuri

2022

APJHS

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Introduction: Cardiometabolic syndrome is a major public health problem that effects various groups of population world over. Overt hypothyroidism is reported to be associated with both adverse cardiometabolic events as well as hematological picture. However, cardiometabolic and hematological consequences of subclinical hypothyroidism (SCH) are yet to be evaluated in different population. In the present study, we evaluated cardiometabolic and hematological consequences of SCH in a middle aged population from Agartala, Tripura, India. Methodology: The study was conducted on 193 patients attending the ENT OPD of Tripura Medical College and Dr. B.R. Ambedkar Memorial Teaching Hospital, Hapania, Agartala. Subjects having diabetes mellitus, hypertension, patients having thyroxin, antithyroid drugs and antilipidemic drug users, established cancer patients, pregnant woman, and women receiving oral contraceptive pills were excluded from inclusion in the study. Results: The mean age of the subjects was 40.13 years, and females constituted around 65 % of total subjects. The analyses showed a significant difference the RBC count, HB concentration, and a non-significant difference in WBC count between euthyroid and hypothyroid subjects, while platelets showed no significant difference between the groups. There was a significant increase in total cholesterol level and level of LDL cholesterol as well as blood pressure, blood sugar level, and waist circumference in hypothyroid subjects in comparison to euthyroid subjects. Conclusion: The study concluded that the subjects with hypothyroidism have worse cardiometabolic parameters with alteration in lipid profile. Thyroid dysfunction affects all blood parameters except platelets. The follow-up of patients with hypothyroidism should include the complete blood count and evaluation of lipid profile and other cardiometabolic parameters.

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Section: Discussionsupporting

confidence: 90%

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Saha

Choudhuri

2022

APJHS

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“…The CRP is an established indicator of peripheral atherosclerotic vascular disease and coronary artery atherosclerotic disease (CAD). 17 The findings are in agreement with previous studies, [18][19][20] but contrary to other studies. 21,22 These studies 21,22 yielded conflicting observations of dyslipidemia in SCH that is in contrast to present and previous studies.…”

Section: Discussionsupporting

confidence: 84%

“…These findings are in agreement with previous studies. [17][18][19] Control and cases were age and gender matched. Total cholesterol (TC), Triglycerides (TAG), LDLc and HDLc showed revealed statistically significant differences between control and cases (P <0.05).…”

Section: Discussionmentioning

confidence: 99%

Subclinical Hypothyroidism;

Memon

Kumar²,

Talpur

et al. 2019

TPMJ

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Objectives: Analysis of thyroid function test, C-reactive protein (CRP) and lipids profile in subclinical hypothyroidism (SCH) as indicators of vascular atherosclerotic disease. Study Design: Cross sectional (case control) study. Place and Duration: Department of Surgery, Liaquat University of Medical and Health Sciences Hospital from January 2016 to July 2017. Materials and Methods: Subjects for this study were selected by inclusion and exclusion criteria. Sampling technique was non-probability purposive sampling. A case of SCH was defined as Thyroid stimulating hormone (TSH) > 6.2 (μIU /ml) with normal T4 and T3 free levels. 5 ml venous blood was collected from peripheral vein. Blood was centrifuged to extract sera for the detection of serum TSH, T4 and T3, and CRP. 12 hours fasting was mandatory for blood lipid detection. Data was analyzed on software SPSS 22.0 (P-value ≤0.05) at 95% confidence interval (P-value ≤0.05). Results: Cases showed high TC, TAG and LDLc with low HDLc compared to controls (P<0.05). Serum TSH was elevated in cases compared to controls (P=0.0001). Serum CRP in controls was noted as 2.75±1.12 ng/ml compared to 9.41±1.58 ng/ml in cases (P=0.0001). Pearson`s correlation shows serum CRP was negative correlated with serum T3 (r= -0.180, P=0.074), and serum T4 (r= -0.2250, P=0.025), but positive correlated with serum TSH (r= 0.626, P=0.0001). Conclusion: Subclinical hypothyroid is associated with dyslipidemia and raised C-reactive protein and both may be interpreted as indicators of vascular atherosclerotic disease.

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“…Vitamin D levels are lowered in obese individuals in comparison to non-obese; this may be explained by the diminished degrees of exercise, exposure to sunlight, and reserving 25 hydroxy-vitamin D in adipose tissues. 14,15 Since older people are less effective than younger people in producing vitamin D from sunlight and older people's kidneys have a lower ability to transform vitamin D into its active form, age could be predicted to correlate with vitamin D levels adversely. However, for this study, there were no significant differences in confounder (BMI and age) among the studied groups Superscripts (a,b,c,d) refer to significant differences among groups, such that (a) the level is significantly higher than the level in (b) and the last is significantly higher than the level in (c) and so on.…”

Section: Discussionmentioning

confidence: 99%

Impact of serum vitamin D level on selected bone-related markers in obese- type 2 diabetes patients

Raheem

Ali²,

AL-Nuaimi³

et al. 2023

F1000Res

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Background: Type 2 diabetes mellitus (T2DM) is accompanied by an increased risk for skeletal fractures. The causes are probably a mix of factors, including poor glycemic control, a higher risk of falling due to hypoglycemia, osteopenia, bone quality deterioration, and drug side effects related to bone fragility. Undercarboxylated osteocalcin (ucOC) is a protein generated by osteoblasts that affects insulin secretion and sensitivity. Methods: A total number of 47 obese (BMI ˃ 30) patients with confirmed type 2 diabetes were selected depending on the American Diabetes Association ADA criteria. The control participants were similar to the patients in age and gender, with a total number of 43 obese (BMI ˃ 30) and healthy subjects chosen from the general population. The selected subjects were grouped according to their serum vitamin D levels. Their blood specimen was used for assaying ucOC, parathyroid hormone (PTH), and vitamin D3 levels by specific ELISA kits, and to estimate calcium (Ca2+) levels and inorganic phosphate (PO43−) via enzymatic colorimetric methods. Results: Serum parathyroid hormone and inorganic phosphate median (IQR) values were markedly increased in patients with T2DM when compared to healthy controls, whereas serum calcium and ucOC levels were lowered significantly in diabetic patients when compared to healthy controls. This was irrespective of serum vitamin D levels. Conclusions: Elevated serum levels of PTH and PO43− values in obese type 2 diabetic patients compared to obese non-diabetic controls were accompanied by a significant decrease in ucOC and Ca2+ levels, irrespective of serum vitamin D levels. Hence, serum vitamin D3 levels had no significant impact on levels of ucOC, PTH, Ca2+, and PO43− in obese patients with type 2 diabetes.

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Dyslipidemia in Subclinical Hypothyroidism: A Case-Control Study

Cited by 5 publications

References 41 publications

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Subclinical Hypothyroidism;

Impact of serum vitamin D level on selected bone-related markers in obese- type 2 diabetes patients

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