Dyslipidemia in people living with HIV-AIDS in a tertiary hospital in South-East Nigeria

Abstract

IntroductionAcross the globe, human immunodeficiency virus (HIV) infection is a healthcare problem. Dyslipidemia, a cardiovascular risk factor, is known to occur with the progression of HIV infection. The factors which influence dyslipidemia in HIV subjects have not been completely identified. The aim of this study was to evaluate serum lipids and identify the factors which might influence dyslipidemia in treatment-naïve HIV subjects in Owerri, Nigeria.MethodsThis was a cross-sectional study of treatment-naïve HIV subjects. Anthropometric and demographic data were collected. Serum LDL serum cholesterol, serum high density lipoprotein cholesterol, serum triglyceride, spot urine creatinine, spot urine osmolality, spot urine protein, serum creatinine, 24-hour urine protein, 24-hour urine osmolality, 24-hour urine creatinine, creatinine clearance and hemoglobin were conducted. The variables were compared between those who have dyslipidemia and those who have no dyslipidemia.ResultsThe mean age of the subjects was 39 ± 11 years. Females constituted 72.0% and males 28.0%. Elevated serum LDL was present in 17.6%, elevated serum total cholesterol in 11.4%, elevated serum triglyceride in 9.9% and low serum HDL in 34.4% of the subjects. There was significant association between dyslipidemia and CD4 cells count, as well as anemia. There was no significant association between dyslipidemia and urine protein, urine creatinine, urine osmolality, creatinine clearance, as well as 24-hour urine volume.ConclusionThe prevalence of dyslipidemia was high in the study subjects. Abnormal CD4 cells count and anemia were common in treatment-naïve HIV subjects who have dyslipidemia.

Prevalence and predictors of dyslipidemia among hypertensive patients in Lumame Primary Hospital, Amhara, Ethiopia: A cross-sectional study

“…The prevalence of high TG was (24.5%), which lower than previous studies conducted in Uganda (42.1%) [ 47 ], Jordan (41.9%) [ 48 ], (56.1%) [ 49 ], South Africa (59.3%) [ 49 ], Senegal (7.1%) [ 50 ], Malawi (28.7%) [ 51 ], Thailand (49.9%) [ 6 ], and Brazil (65.3%) [ 52 ]. However, this finding is higher than previous studies done in Nigeria (9.9%) [ 53 ]. and Ethiopia (21.0%) [ 54 ].…”

Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia

“…The prevalence of elevated triglyceride (40.2%) in this study is higher than the previous findings reported in Senegal (7.1%) [37], Nigeria (9.9%) [38], Ethiopia (21.0%) [30], and Malawi (28.7%) [39]. However, it is consistent with the study findings reported in Venezuela (39.7%) [40], Jordan (41.9%) [36], and Uganda (42.1%) [33].…”

“…Africa (18.5%) [9]. Unlike many previous studies [22,30,38,[42][43][44][45], low HDL-C is the least prevalent component of dyslipidemia in this study. Advanced age, higher BMI, waking less than 150 minutes per week, raised FBG, and medium socio-economic status were significantly associated with a higher risk of dyslipidemia.…”

Prevalence of Dyslipidaemia using Serum and Salivary Lipids among Primary School Children aged 5 to 12 Years, in Sokoto, Nigeria

“…To further support this, many other studies 9,[21][22][23][24] recorded HDL as the most prevalent lipid type both in local and international studies. The high prevalence of low HDL as shown by Yanai et al 25 in Japan is attributed to less consumption of the poly unsaturated fats.…”