Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study

Abstract

BackgroundNumerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC).MethodsFour hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients’ medical records and telephone interviews. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression.ResultsAbnormal triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels showed statistically significant coexistence with NSCLC compared with controls. Higher levels of TG were associated with a higher risk of NSCLC (OR = 1.541, 95% CI, (1.072–2.215)). The odds ratios (ORs) for NSCLC for normal and high levels of HDL-C versus those with a low level of HDL-C were 0.337(95% CI, (0.242–0.468)) and 0.288(95% CI, (0.185–0.448)), respectively. After adjustment for age, sex, smoking status, hypertension, body mass index, diabetes and lipid profiles, the adjusted OR for normal and high levels of HDL-C were 0.320(95% CI, (0.218–0.470)) and 0.233(95% CI, (0.134–0.407)), respectively. However, after adjustment, high levels of TG increased the risk of NSCLC but not significantly (OR = 1.052, 95% CI (0.671–1.649)).ConclusionsThis study provided evidence that dyslipidemia increased the risk of NSCLC in Chinese population.

Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy

“…Several studies have investigated alterations in lipoprotein levels in these diseases. Decreased HDL-cholesterol concentrations have been reported in patients with oral cancer [36,37] or LC [11,38,39,40]. Our results differ from these studies.…”

High Levels of Low-Density Lipoproteins Correlate with Improved Survival in Patients with Squamous Cell Carcinoma of the Head and Neck

“…So far, there are only a few studies available on serum lipid profiles in SCCHN. In accordance with previous studies [ 4 , 11 , 30 ], we found levels of total cholesterol, LDL and HDL to be lower in SCCHN patients than in controls, although HDL was the only lipoprotein that was statistically significantly lower in the SCCHN patients in our study. Notably, 42% of the patients in our study had T4 tumors.…”

“…The role of lipids in tumor development has been a focus of interest in many recent studies, but findings from different tumor types are often contradictive [ 25 ]. Previous studies have shown an association between blood cholesterol levels and different cancers [ 26 ] such as breast [ 27 ], colorectal [ 28 , 29 ] and lung cancer [ 30 ]. So far, there are only a few studies available on serum lipid profiles in SCCHN.…”

Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies

“…Interestingly, a recent meta-analysis with 28 prospective cohort studies suggested a significantly positive relationship between waist circumference, rather than BMI, and lung cancer risk, suggesting there might have an etiological connection between central obesity and lung cancer development [ 35 ], rather than overall obesity as evidenced by increased BMI. Moreover, as for the lipids profiles, recent evidence indicated that higher high-density lipoprotein cholesterol level is protective against the lung cancer, whereas higher triglyceride is associated with higher lung cancer incidence [ 36 ], and these findings are confirmed by a subsequent case–control study in Chinese patients with and without non-small cell lung cancer [ 37 ]. However, a recent prospective cohort study showed that the association between triglyceride and lung cancer risk may be more complicated than expected and presented as a U-shaped association [ 38 ].…”