Dysbiosis of the upper digestive tract — a harbinger of rheumatoid arthritis?

Гордеев, А. В.; Галушко, Е. А.; Савушкина, Н. М.

doi:10.31146/1682-8658-ecg-163-3-10-15

Cited by 2 publications

(3 citation statements)

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“…Several studies [18,29,30] have shown that, in the case of periapical endodontic lesions, Alflutop ® solution, applied intracanally, had regenerative properties observed one month after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Because both periodontal disease and rheumatoid arthritis have similar pathways [25,29], natural compounds with anti-inflammatory effects and regenerative properties are needed in order to arrest inflammation and to stimulate an organism to regenerate lost tissues. If the regenerative effects proven by studies [21,24] can be expanded on periodontal lesions, we expect Alflutop ® therapy to have a long-term stimulation effect on the alveolar bone's regeneration, but this will be a subject of future research.…”

Section: Discussionmentioning

confidence: 99%

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Measurement of the Clinical Effects of a Marine Fish Extract on Periodontal Healing—A Preliminary Clinical Interventional Study

et al. 2022

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The aim of the study was to assess the clinical effects of periodontal healing using a Romanian pharmaceutical compound of marine fish extract (Alflutop®). Adults with periodontal disease were included in the study group. Gingival inflammation, the degree of tooth mobility, and probing depth (PD) were recorded for each patient before and after therapy. Patients were divided into two groups: group I—after scaling and root planing (SRP), patients followed therapy with marine fish extract, Alflutop®, group II—SRP therapy alone. Statistically significant differences between groups in terms of gingival inflammation reduction (p = 0.045) were found. Tooth mobility reduction, as well as PD improvement, were also noticed after the therapy (p = 0.001), but no statistically significant differences among PD reduction rates were found (p = 0.356). Alflutop® has proven a certain therapeutic efficiency in the treatment of periodontitis in terms of reduction in the clinical signs of inflammation and tooth mobility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Measurement of the Clinical Effects of a Marine Fish Extract on Periodontal Healing—A Preliminary Clinical Interventional Study

et al. 2022

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“…За даними літератури, пацієнти з наявністю «сухого синдрому» демонструють вищий ступінь відходження ясен від поверхні зубів і вищий уміст дріжджових мікроорганізмів у ротовій порожнині. Однак підвищена частота виявлення пародонтиту при РА нібито не асоціюється з розвитком вторинного синдрому Шьогрена [19]. Відсутність розбіжностей у ступені виразності пародонтиту в пацієнтів із таким синдромом і без нього дозволила дійти висновку про те, що патогенез резорбції кісток пародонта може мати спільні ланки з розвитком кістково-суглобної деструкції при РА [20][21].…”

Section: -St 2 -Tnf 3 -Pf 4 -Cf 5 - 6 - 7 - 8 -Af 9 -Il1unclassified

Physics and Chemical, Immunoenzyme and Biochemical Indicators of Oral Fluid in Periodontitis in Patients With Rheumatoid Arthritis

Syniachenko¹,

Iermolaieva²,

Ярова³

et al. 2021

Ukr. Dent. Alm.

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Infection with comorbid periodontitis due to transient bacteremia in patients with rheumatoid arthritis (RA) can lead to microbial colonization outside the mouth and increase systemic immune inflammation. Periodontitis-induced endotoxemia increases the sensitivity of RA patients to autoantigens by activating membrane proteins, pro-inflammatory enzymes, and cytokines. RA and periodontitis have similar osteoclasia, allelic genes and general imbalance in the state of the cytokine network, and carbamylation of proteins and the formation of extracellular traps of neutrophils are associated with simultaneous autoimmune imbalance in the combination of RA and periodontitis, but the listed pathogenetic mechanisms require further study. The purpose and objectives of the study: to study the properties of the oral fluid in periodontitis in patients with RA, to determine the clinical and pathogenetic significance of changes in physicochemical, enzyme immunoassay and biochemical parameters in the pathology of the oral cavity and joints, to compare the indicators with the nature of the gingival microbiota. Material and methods. The study included 173 RA patients aged 18-76 years (average 46 years), among whom there were 21% of men and 79% of women. The duration from the first manifestation of the disease averaged 10 years. The frequency of RA seropositivity for rheumatoid factor in the blood was 75%, and for antibodies to citrulline cyclic peptide was 73%. The І, ІІ and ІІІ degrees of disease activity, respectively, were stated in 26%, 44% and 30% of cases, and the ratio of I, II, III and IV stages of the pathological process was 1: 6: 5: 3. Results. We studied the physicochemical adsorption-rheological properties of the oral fluid (surface tension, viscoelasticity, relaxation), the levels of pro-inflammatory cytokines in it, the concentration of aminopeptide, peptide, nucleotide and chromatophore fractions of average weight molecules, the ratio with similar parameters in blood serum. To assess the number of aerobic and facultative anaerobic microorganisms vegetating on the gingival mucosa, the method of sterile paper discs was used. Compared with healthy people in the control group, 99% of the number of RA patients has an increase in the concentration of interleukin 1b in the oral fluid (22 times), 98% of tumoronecrotic factor a (7 times), 43% of the average increase in the average weight molecules (by 47%), at the same time, the parameters are associated with the presence of secondary Sjogren's syndrome, with the severity of the course of both articular syndrome, and periodontitis, which is accompanied by a longer relaxation time of oral washings (by 36%), but their lower interfacial activity (by 11%), the ratio of the tumor necrosis factor parameter a with the level of this pro-inflammatory cytokine in the blood (by 70%), and there are dispersion relationships of individual indicators of the oral fluid with the vegetation on the gums of bacterioids, bifidobacteria, Escherichia coli, megaspheres, moraxellas, neisseria, propionibacteria, proteus, pseudomones, sarcins and streptococcus. Conclusions: the obtained data dictate the need to develop new approaches to medical technology for individual pathogenetic therapy of chronic generalized periodontitis, taking into account its etiology in RA patients, identifying criteria that allow assessing the activity of the pathological process, predicting the nature of the course of the disease and the effectiveness of treatment measures.

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Dysbiosis of the upper digestive tract — a harbinger of rheumatoid arthritis?

Cited by 2 publications

References 0 publications

Measurement of the Clinical Effects of a Marine Fish Extract on Periodontal Healing—A Preliminary Clinical Interventional Study

Measurement of the Clinical Effects of a Marine Fish Extract on Periodontal Healing—A Preliminary Clinical Interventional Study

Physics and Chemical, Immunoenzyme and Biochemical Indicators of Oral Fluid in Periodontitis in Patients With Rheumatoid Arthritis

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