Dysbiosis in food allergy and implications for microbial therapeutics

Berin, M. Cecilia

doi:10.1172/jci144994

Cited by 11 publications

(13 citation statements)

References 23 publications

(9 reference statements)

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“…Further studies revealed that commensals activated the MyD88-RORt pathway, resulting in the development of T reg cells [128]. These significant experiments aid in a better understanding of the functional significance of dysbiosis in patients with food allergies [129].…”

Section: Allergy and Microbiotamentioning

confidence: 93%

Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics

Aldakheel

2021

IJERPH

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The prevalence of allergic diseases is regarded as one of the key challenges in health worldwide. Although the precise mechanisms underlying this rapid increase in prevalence are unknown, emerging evidence suggests that genetic and environmental factors play a significant role. The immune system, microbiota, viruses, and bacteria have all been linked to the onset of allergy disorders in recent years. Avoiding allergen exposure is the best treatment option; however, steroids, antihistamines, and other symptom-relieving drugs are also used. Allergen bioinformatics encompasses both computational tools/methods and allergen-related data resources for managing, archiving, and analyzing allergological data. This study highlights allergy-promoting mechanisms, algorithms, and concepts in allergen bioinformatics, as well as major areas for future research in the field of allergology.

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Section: Allergy and Microbiotamentioning

confidence: 93%

Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics

Aldakheel

2021

IJERPH

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“…The beneficial effect was observed after the end of the probiotic intervention and was not extended for the further nine months of follow-up. The treatment period in most of the clinical studies evaluating the efficacy of probiotics in AD lasted no more than three months [11][12][13][14]37,38], but the intervention time was extended up to six months in AD prevention studies [19][20][21][22]. A meta-analysis by Jiang et al showed that the SCORAD scores in studies with treatment periods of >8 weeks decreased more than in studies with treatment periods of <8 weeks [34], but the authors did not assess the optimal duration of probiotic intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Gabet et al demonstrated that sensitization to egg white and CMP at age 18 months significantly increased the risk of asthma later in childhood [43]. Thus, the early onset of AD may be a window of opportunity to modify the profile sensitization by therapeutic interventions, including probiotics [12,13]. Elazab et al performed a meta-analysis of randomized, placebo-controlled trials to assess the effects of probiotic supplementation on atopic sensitization and asthma/wheeze prevention in children [44].…”

Section: Discussionmentioning

confidence: 99%

“…Children with AD show a low biodiversity of their gut microbiota, particularly a lack of Bacteroides diversity, and a high prevalence of Clostridium difficile colonization [10,11]. Therefore, one of the prophylactic and therapeutic measures in allergies may involve the use of probiotics [12]. The World Allergy Organization guideline panel suggests to use probiotics for prevention of allergy in pregnant women at high risk for having an allergic child, in women who breastfeed infants at high risk of developing allergy, and in infants at high risk of developing allergy [13].…”

Section: Introductionmentioning

confidence: 99%

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The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study

Cukrowská

Ceregra²,

Maciorkowska

et al. 2021

Nutrients

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Probiotics seem to have promising effects in the prevention and treatment of allergic conditions including atopic dermatitis (AD) and food allergy. The purpose of this multicenter randomized placebo-controlled trial was to evaluate the effectiveness of a probiotic preparation comprising Lactobacillus rhamnosus ŁOCK 0900, Lactobacillus rhamnosus ŁOCK 0908, and Lactobacillus casei ŁOCK 0918 in children under 2 years of age with AD and a cow’s milk protein (CMP) allergy. The study enrolled 151 children, who—apart from being treated with a CMP elimination diet—were randomized to receive the probiotic preparation at a daily dose of 109 bacteria or a placebo for three months, with a subsequent nine-month follow-up. The primary outcomes included changes in AD symptom severity assessed with the scoring AD (SCORAD) index and in the proportion of children with symptom improvement (a SCORAD score decreased by at least 30% in comparison with that at baseline). After the three-month intervention, both the probiotic and placebo groups showed a significant (p < 0.0001) decrease in SCORAD scores, which was maintained nine months later. The percentage of children who showed improvement was significantly higher in the probiotic than in the placebo group (odds ratio (OR) 2.56; 95% confidence interval (CI) 1.13–5.8; p = 0.012) after three months. Probiotics induced SCORAD improvement mainly in allergen sensitized patients (OR 6.03; 95% CI 1.85–19.67, p = 0.001), but this positive effect was not observed after nine months. The results showed that the mixture of probiotic ŁOCK strains offers benefits for children with AD and CMP allergy. Further research is necessary to assess the effect of probiotic supplementation on the development of immune tolerance. (ClinicalTrials.gov NCT04738565)

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“…Esber and colleagues demonstrated the potentially beneficial role of three probiotic strains in cow’s milk allergy with regard to tolerance acquisition ( 66 ). Microbes from the Clostridia class and two other commensal species were enriched in healthy twins without FA ( 67 ). Abdel-Gadir and colleagues found that therapy with commensals including Clostridiales species suppressed FA in mice by inducing Treg cells expressing the transcription factor ROR-γt in a MyD88-dependent manner ( 68 ).…”

Section: Discussionmentioning

confidence: 99%

Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes

Zhou

et al. 2021

Front. Immunol.

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This research aimed to investigate the allergic reaction of C3H/HeJ mice after sensitization with ovalbumin (OVA) without any adjuvant and to analyze the association between intestinal microbiota and allergy-related immune cells in mesenteric lymph nodes (MLN). The allergic responses of C3H/HeJ mice orally sensitized with OVA were evaluated, and immune cell subsets in spleen and MLN and cytokines were also detected. The intestinal bacterial community structure was analyzed, followed by Spearman correlation analysis between changed gut microbiota species and allergic parameters. Sensitization induced a noticeable allergic response to the gavage of OVA without adjuvant. Increased levels of Th2, IL-4, CD103+CD86+ DC, and MHCII+CD86+ DC and decreased levels of Th1, Treg, IFN-γ, TGF-β1, and CD11C+CD103+ DC were observed in allergic mice. Furthermore, families of Lachnospiraceae, Clostridiaceae_1, Ruminococcaceae, and peprostreptococcaceae, all of which belonging to the order Clostridiales, were positively related to Treg and CD11C+CD103+ DC, while they were negatively related to an allergic reaction, levels of Th2, CD103+CD86+ DC, and MHCII+CD86+ DC in MLN. The family of norank_o_Mollicutes_RF39 belonging to the order Mollicutes_RF39 was similarly correlated with allergic reaction and immune cells in MLN of mice. To sum up, allergic reactions and intestinal flora disturbances could be induced by OVA oral administration alone. The orders of Clostridiales and Mollicutes_RF39 in intestinal flora are positively correlated with levels of Treg and CD11C+CD103+ DC in MLN of mice.

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Dysbiosis in food allergy and implications for microbial therapeutics

Cited by 11 publications

References 23 publications

Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics

Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics

The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study

Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes

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