Dysbiosis and leaky gut in hyper-inflated COPD patients: Have smoking and exercise training any role?

Comini, Laura; Pasini, Evasio; Porta, Roberto; Olivares, Adriana; Testa, Cristian; Scalvini, Simonetta; Vitacca, Michele

doi:10.1016/j.resmer.2023.100995

Search citation statements

Order By: Relevance

Paper Sections

Select...

Mechanisms Regulating Gla1

Bacterial Translocation1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gut dysbiosis promotes gut inflammation and epithelial barrier damage, leading to gut including asthma and COPD [ 29 , 30 ]. The epithelial cells are arranged tightly with via junctional complexes including junctional proteins (tight, adherent and gap junctions) and desmosomes.…”

Section: Mechanisms Regulating Glamentioning

confidence: 99%

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Eladham,

Selvakumar,

Saheb Sharif-Askari

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Mechanisms Regulating Glamentioning

confidence: 99%

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Eladham,

Selvakumar,

Saheb Sharif-Askari

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…Impaired gut integrity increases the permeability of the gut barrier, facilitating bacterial translocation, which has been observed in several lung diseases [ 42 , 43 ]. Exposure to cigarette smoke for 10 weeks (5 days a week) significantly increased the bacterial translocation rate in the MLNs [ 44 ].…”

Section: Bacterial Translocationmentioning

confidence: 99%

Gut Microbiome as a Possible Cause of Occurrence and Therapeutic Target in Chronic Obstructive Pulmonary Disease

Lim¹,

Song²,

Shin

2023

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

As a long-term condition that affects the airways and lungs, chronic obstructive pulmonary disease (COPD) is characterized by inflammation, emphysema, breathlessness, chronic cough, and sputum production. Currently, the bronchodilators and anti-inflammatory drugs prescribed for COPD are mostly off-target, warranting new disease management strategies. Accumulating research has revealed the gut–lung axis to be a bidirectional communication system. Cigarette smoke, a major exacerbating factor in COPD and lung inflammation, affects gut microbiota composition and diversity, causing gut microbiota dysbiosis, a condition that has recently been described in COPD patients and animal models. For this review, we focused on the gut–lung axis, which is influenced by gut microbial metabolites, bacterial translocation, and immune cell modulation. Further, we have summarized the findings of preclinical and clinical studies on the association between gut microbiota and COPD to provide a basis for using gut microbiota in therapeutic strategies against COPD. Our review also proposes that further research on probiotics, prebiotics, short-chain fatty acids, and fecal microbiota transplantation could assist therapeutic approaches targeting the gut microbiota to alleviate COPD.

show abstract

Dysbiosis and leaky gut in hyper-inflated COPD patients: Have smoking and exercise training any role?

Cited by 2 publications

References 48 publications

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Gut Microbiome as a Possible Cause of Occurrence and Therapeutic Target in Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About