“Dysautonomia”: a plea for precision

Benarroch, Eduardo E.

doi:10.1007/s10286-020-00749-3

Cited by 11 publications

(13 citation statements)

References 15 publications

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“…Firstly, the majority of studies were based on patient-reported questionnaires and/or scales, implying the assumption that visceral symptoms automatically reflect autonomic nervous system dysfunction. This is incorrect, as the way visceral symptoms are perceived by the individual is the result of complex information processing in the central nervous system [ 82 ]. Relying on data from questionnaires and scales may therefore be misleading and not truly indicate autonomic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Autonomic dysfunction in progressive supranuclear palsy

et al. 2022

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Background The degree of involvement of the autonomic nervous system in progressive supranuclear palsy (PSP) has been investigated in several studies, often providing conflicting results. There is a need for a better characterization of autonomic dysfunction in PSP, to enhance our understanding of this highly disabling neurodegenerative disease including patients’ needs and possibly be of value for clinicians in the differential diagnosis among Parkinsonian syndromes. Methods We applied a systematic methodology to review existing literature on Pubmed regarding autonomic nervous system involvement in PSP. Results PSP reported quite frequently symptoms suggestive of autonomic dysfunction in all domains. Cardiovascular autonomic testing showed in some cases a certain degree of impairment (never severe). There was some evidence suggesting bladder dysfunction particularly in the storage phase. Dysphagia and constipation were the most common gastrointestinal symptoms. Instrumental tests seemed to confirm sudomotor and pupillomotor disturbances. Conclusions PSP patients frequently reported visceral symptoms, however objective testing showed that not always these reflected actual autonomic impairment. Further studies are needed to better delineate autonomic profile and its prognostic role in PSP.

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Section: Discussionmentioning

confidence: 99%

Autonomic dysfunction in progressive supranuclear palsy

et al. 2022

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“…Because heart rate and cardiac output are so tightly regulated, sinus tachycardia is usually an appropriate compensatory response and rarely reflects dysautonomia. 166 , 182 , 183 , 184 …”

Section: Description Of Pathwaymentioning

confidence: 99%

“…This results in a reduced stroke volume at any degree of orthostatic stress and ultimately, compensatory tachycardia. 182 , 183 , 188…”

Section: Description Of Pathwaymentioning

confidence: 99%

2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play

Gluckman¹,

Bhave²,

Allen³

et al. 2022

Journal of the American College of Cardiology

273

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“…Inappropriate sinus tachycardia and exercise intolerance are often associated after COVID-19 infection. It is usually an inappropriate compensatory response that reflects dysautonomia, hyperadrenergic, and inflammatory post-infection state and the presence of metabolism alterations and immune dysfunction [151][152][153]. Deconditioning represents a final common pathway starting from these two conditions.…”

Section: Post-covid-19 Tachycardia Exercise Intolerance With Post-exe...mentioning

confidence: 99%

“…Once symptoms develop, a downward spiral characterized by short periods of bedrest that produce exercise intolerance, postexertional malaise, and tachycardia leads to further inactivity and worsening of cardiovascular deconditioning with even more debilitating symptoms and chronic fatigue [35]. Patients with COVID-19 reported at home chronic fatigue and dyspnea by 30% and 15%, respectively, at 6 months [152].…”

Section: Post-covid-19 Tachycardia Exercise Intolerance With Post-exe...mentioning

confidence: 99%

Perspective Chapter: Cardiovascular Post-Acute COVID-19 Syndrome – Definition, Clinical Scenarios, Diagnosis, and Management

Centorbi¹,

Garau²,

Borsi³

et al. 2024

New Insights on Cardiomyopathy

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Post-acute COVID-19 syndrome (PACS) describes the clinical condition of some SARS-CoV-2-infected patients in which a wide range of signs and symptoms that persist for several months after the acute phase of the disease. Cardiovascular symptoms including chest pain, dyspnea, elevated blood pressure, palpitations, inappropriate tachycardia, fatigue, and exercise intolerance are common in this condition. Some infected patients develop cardiovascular diseases such as myocarditis, pericarditis, new or worsening myocardial ischemia due to obstructive coronary artery disease, microvascular dysfunction, stress cardiomyopathy, thromboembolism, cardiovascular sequelae of pulmonary disease, arrhythmias, while others have cardiovascular symptoms without objective evidence of cardiovascular abnormalities. In the present chapter, definition, spectrum of manifestations, clinical scenarios, diagnosis, management, and therapy of cardiovascular PACS will be discussed.

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“Dysautonomia”: a plea for precision

Cited by 11 publications

References 15 publications

Autonomic dysfunction in progressive supranuclear palsy

Autonomic dysfunction in progressive supranuclear palsy

2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play

Perspective Chapter: Cardiovascular Post-Acute COVID-19 Syndrome – Definition, Clinical Scenarios, Diagnosis, and Management

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