Autonomic dysfunction in progressive supranuclear palsy

Baschieri, Francesca; Vitiello, Maria; Cortelli, Pietro; Calandra-Buonaura, Giovanna; Morgante, Francesca

doi:10.1007/s00415-022-11347-w

Cited by 8 publications

(19 citation statements)

References 84 publications

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“…Photophobia can also be considered as an autonomic nervous system symptom as is the case in Parkinson's disease, multiple system atrophy, or PSP [34]. It is then often associated with a pupillomotor dysfunction [8]. We described this autonomic involvement in DLB in a previous article, where we demonstrated that DLB patients also had other early neurovegetative disorders, namely rhinorrhea, sicca syndrome, and constipation [3].…”

Section: Discussionmentioning

confidence: 99%

“…Photophobia was first associated with ophthalmological diseases, such as lesions of the cornea, and subsequently with neurologic and neurogeriatric conditions, such as migraine [5], blepharospasm [6], and progressive supranuclear palsy (PSP) [7]. Photophobia, present in 43%-100% of PSP patients [8], appears to cause a reduction in quality of life, with an impact on outdoor activities [9]. Photophobia has been very rarely studied in other neurocognitive diseases.…”

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confidence: 99%

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Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies

Tisserand

Crétin

Mondino

et al. 2023

Euro J of Neurology

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Background and objectives Photophobia is a sensory disturbance provoked by light. Little is known about the association between photophobia and dementia with Lewy bodies (DLB). In this study, we aimed to identify the frequency and the neural basis of photophobia in prodromal and mild DLB. Methods One hundred and thirteen DLB patients, 53 Alzheimer's disease (AD) patients, 20 AD and DLB patients, 31 patients with other neurocognitive diseases (including prodromal and mild demented patients), and 31 healthy elderly controls were included in this case–control study. Photophobia was systematically looked for and compared between groups. Among a selection of 77 DLB patients, we used voxel‐based morphometry (VBM) to compare those with and those without photophobia (gray matter volume; SPM12, XjView, and Matlab R2021b software). Results The frequency of photophobia was higher in the DLB group (47.3%) than in the other groups (p = 0.002). The photophobia questionnaire score was higher in the DLB group than in the AD group (p = 0.001). Comparison between DLB patients with and those without photophobia showed decreased gray matter in the photophobia subgroup, in the right precentral cortex, in the eyelid motor region of Penfield's homunculus (p = 0.007, family‐wise error [FWE] corrected). Conclusions Photophobia is a quite frequent symptom of prodromal and mild DLB. The neural basis of photophobia in DLB involves the right precentral cortex, which could have a role in the decrease of cerebral excitability, but also the motricity of the eyelids.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies

Tisserand

Crétin

Mondino

et al. 2023

Euro J of Neurology

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“…Sudden onset or stepwise progression is suspicious of a vascular cause, while a rapid progression could evoke an autoimmune encephalitis or prion disease. Although PSP patients can report autonomic-like symptoms, they are usually not severe and do not dominate the clinical picture [10].…”

Section: Andandmentioning

confidence: 99%

Progressive supranuclear palsy: current approach and challenges to diagnosis and treatment

Carpentier

McFarland

2023

Current Opinion in Neurology

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Purpose of review Since the original description of progressive supranuclear palsy (PSP) by Steele, Richardson and Olszewski, the clinical spectrum of PSP has expanded and now includes multiple phenotypic variants linked by a common disease. In this review, we discuss the evolution of the PSP syndrome and clinical criteria, with a particular focus on the 2017 Movement Disorders Society PSP criteria, its application and limitations. We also discuss our current approach to diagnosis and treatment. Recent findings There is a significant overlap between the different variants of PSP and multiple phenotypes that may be applied to the same patient simultaneously. Variant severity and predominance also evolve throughout the course of the disease. Each variant and level of certainty is associated with different specificity and sensitivity for underlying disease. The differential diagnosis of PSP is continuously evolving and includes other tauopathies, neurodegenerative, genetic, autoimmune and infectious disorders. MRI measurements can aid in the diagnosis. The first guidelines to help with clinical management of those patients have been recently published. Summary Although much improved, clinical PSP criteria alone remain insufficient and emphasize the need for improved biomarkers to identify patients at early stages to direct appropriate therapeutic strategies and target potential research.

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“…Dysautonomia and the GI symptoms of PSP are not as well-recognized as those occurring in PD, despite the relatively high rate of occurrence and higher severity of symptoms. [147][148][149][150] Some studies suggest that up to 80% of individuals with PSP experience GI symptoms. 151 Though constipation is the most common GI symptom in PD and MSA, dysphagia ranks first in PSP.…”

Section: Progressive Supranuclear Palsymentioning

confidence: 99%

An Overview of Gastrointestinal Dysfunction in Parkinsonian Syndromes

Talman,

Safarpour

2023

Semin Neurol

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Gastrointestinal (GI) dysfunction is a common nonmotor symptom in Parkinson's disease (PD) as well as other parkinsonian syndromes and may precede the onset of motor symptoms by decades. Involvement of all segments of the GI tract can lead to altered responses to medications and worsened quality of life for patients. While some GI symptoms occur in isolation, others overlap. Therefore, understanding the changes in different segments of the GI tract and how they relate to altered responses to PD treatment can guide both diagnostic and pharmacological interventions. Gut microbiota plays a critical role in immune activity and modulation of the enteric and central nervous systems. Understanding this bidirectional relationship helps to elucidate the pathogenesis of neurodegeneration. This review will describe the current understanding of how GI dysfunction develops in parkinsonian syndromes, common symptoms in PD and related disorders, and available treatments.

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Autonomic dysfunction in progressive supranuclear palsy

Cited by 8 publications

References 84 publications

Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies

Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies

Progressive supranuclear palsy: current approach and challenges to diagnosis and treatment

An Overview of Gastrointestinal Dysfunction in Parkinsonian Syndromes

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