Dysarthria and Quality of Life in neurologically healthy elderly and patients with Parkinson's disease

Lirani-Silva, Camila; Mourão, Lúcia Figueiredo; Gobbi, Lilian Teresa Bucken

doi:10.1590/2317-1782/20152014083

Cited by 28 publications

(17 citation statements)

References 22 publications

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“…Another study suggested that the difficulties of the listener to understand the speech of the subject with ALS and the unavoidable repetitions, decrease the communication rate of these individuals 7 . These difficulties have been also described in other neurodegenerative diseases such as Parkinson's disease 6 . The individual's perception of their own illness and communication difficulties were frequently self-reported by the participants in this study, as in the statements: "I worry about my speech difficulties" and "I think my speech can change".…”

mentioning

confidence: 79%

“…These changes, together with the loss of functional independence caused by ALS, lead to an extremely discouraging situation for the individual 5 . Studies reaffirm that quality of life is largely affected by the presence of dysarthria caused by various underlying diseases 6,7 . The decline in functional capacity coupled with the relatively preserved cognitive capacity observed in subjects with ALS are considered the primary problems to be addressed.…”

Section: Introductionmentioning

confidence: 94%

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Dysarthria and quality of life in patients with amyotrophic lateral sclerosis

Neto

Constantini

2017

Rev. CEFAC

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Purpose: to analyze the impact of dysarthria on the quality of life in patients with amyotrophic lateral sclerosis.Methods: the study consisted of 32 subjects, divided into two groups (control group and study group) who underwent an initial interview for background information, followed by an evaluation based on the Dysarthria Assessment Protocol and completion of quality of life questionnaire "Living with Dysarthria -(LwD)". Exploratory data analysis was collected through mean, median, SD, minimum and maximum measures. A comparison was performed between the studied groups and a correlation was carried out between scores. The significance level adopted was 5%.Results: according to the findings, all sub-items analyzed by the dysarthria assessment protocol were statically significant (p <0.001) when comparing the groups. Regarding quality of life, a moderate positive correlation (p = 0.0008; Spearman's coefficient = 0.75202) was observed between the total score of the two protocols used, indicating that the higher the degree of dysarthria, the worse the Quality of Life (QOL) of the subject, according to the parameters evaluated.Conclusion: dysarthria affects all speech parameters herein assessed, in varying degrees, negatively impacting communication and quality of life.

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confidence: 79%

Section: Introductionmentioning

confidence: 94%

Dysarthria and quality of life in patients with amyotrophic lateral sclerosis

Neto

Constantini

2017

Rev. CEFAC

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“…We observed increased cell death and expression of apoptotic regulator proteins in all muscles of the extrinsic tongue with age, a reduction in muscle fiber number in the GG and SG, and higher variability of myofiber size in the SG muscle. The results are indicative of an underlying cellular mechanism that may contribute to age‐related lingual muscle degeneration, and, if also found in humans, may be associated with the development of oromotor decline evidenced in elderly people …”

Section: Discussionmentioning

confidence: 64%

Age‐related effect of cell death on fiber morphology and number in tongue muscle

et al. 2017

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Introduction: Multiple pathways may exist for agerelated tongue muscle degeneration. Cell death is one mechanism contributing to muscle atrophy and decreased function. We hypothesized with aging, apoptosis, and apoptotic regulators would be increased, and muscle fiber size and number would be reduced in extrinsic tongue muscles. Methods: Cell death indices, expression of caspase-3 and Bcl-2, and measures of muscle morphology and number were determined in extrinsic tongue muscles of young and old rats. Results: Significant increases in cell death, caspase-3, and Bcl-2 were observed in all extrinsic tongue muscles along with reductions in muscle fiber number in old rats. Discussion: We demonstrated that apoptosis indices increase with age in lingual muscles and that alterations in apoptotic regulators may be associated with age-related degeneration in muscle fiber size and number. These observed apoptotic processes may be detrimental to muscle function, and may contribute to degradation of cranial functions with age.

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“…In the area of phonation, insufficient breath support, reduction in phonation time, increased acoustic noise, instability of articulatory organs, microperturbations of frequency/amplitude, and harsh breathy voice quality has been observed [9,12]. HD leads to serious complications in daily communication of patients with PD [13]. Generally, HD was found to be more severe in the advanced stages of PD [14].…”

Section: Introductionmentioning

confidence: 99%

Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

et al. 2018

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Hypokinetic dysarthria, which is associated with Parkinson's disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients' voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11-26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.

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Dysarthria and Quality of Life in neurologically healthy elderly and patients with Parkinson's disease

Abstract: The degree of modification of speech and voice of patients with PD resembles those seen in normal aging process, with the exception of prosody and the habitual frequency, which are related to the greatest negative impact on the QoL of patients with PD.

Cited by 28 publications

References 22 publications

Dysarthria and quality of life in patients with amyotrophic lateral sclerosis

Dysarthria and quality of life in patients with amyotrophic lateral sclerosis

Age‐related effect of cell death on fiber morphology and number in tongue muscle

Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

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