Dynamics of viscous amphiphilic films supported by elastic solid substrates

Voinova, Marina; Jonson, M.; Kasemo, Bengt Herbert

doi:10.1088/0953-8984/9/37/011

Cited by 42 publications

(46 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If ΔD n is sufficiently large, the QCM-D is sensitive to the viscoelastic properties of the film, described by the complex shear modulus. By a continuum model based on the analysis of shear wave propagation in viscous media, the response of the QCM can be related to the areal mass density of the film, bound to the surface of the sensor under no-slip conditions, and its viscoelastic properties [38][39][40].…”

Section: Qcm-dmentioning

confidence: 99%

Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures

et al. 2014

View full text Add to dashboard Cite

A combined setup of quartz crystal microbalance and generalized ellipsometry can be used to comprehensively investigate complex functional coatings comprising stimuli-responsive polymer brushes and 3D nanostructures in a dynamic, noninvasive in situ measurement. While the quartz crystal microbalance detects the overall change in areal mass, for instance, during a swelling or adsorption process, the generalized ellipsometry data can be evaluated in terms of a layered model to distinguish between processes occurring within the intercolumnar space or on top of the anisotropic nanocolumns. Silicon films with anisotropic nanocolumnar morphology were prepared by the glancing angle deposition technique and further functionalized by grafting of poly-(acrylic acid) or poly-(N-isopropylacrylamide) chains. Investigations of the thermoresponsive swelling of the poly-(N-isopropylacrylamide) brush on the Si nanocolumns proved the successful preparation of a stimuli-responsive coating. Furthermore, the potential of these novel coatings in the field of biotechnology was explored by investigation of the adsorption of the model protein bovine serum albumin. Adsorption, retention, and desorption triggered by a change in the pH value is observed using poly-(acrylic acid) functionalized nanostructures, although generalized ellipsometry data revealed that this process occurs only on top of the nanostructures. Poly-(N-isopropylacrylamide) is found to render the nanostructures non-fouling properties.

show abstract

Section: Qcm-dmentioning

confidence: 99%

Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Furthermore, the effective thickness before and after phage addition was calculated using the Voigt based model consisting of an elastic element (spring) in parallel with a viscous element (dashpot). 18,20,21 The data of several overtones (third to seventh) were fitted using the software Qtools (Q-Sense AB, Sweden) keeping as fixed parameters the density and the viscosity of the fluid as 1.0 g⋅cm -3 and …”

Section: Qcm-d Resultsmentioning

confidence: 99%

Real-time analysis of dual-display phage immobilization and autoantibody screening using quartz crystal microbalance with dissipation monitoring

Rajaram¹,

Losada-Pérez²,

Vermeeren³

et al. 2015

IJN

View full text Add to dashboard Cite

Over the last three decades, phage display technology has been used for the display of target-specific biomarkers, peptides, antibodies, etc. Phage display-based assays are mostly limited to the phage ELISA, which is notorious for its high background signal and laborious methodology. These problems have been recently overcome by designing a dual-display phage with two different end functionalities, namely, streptavidin (STV)-binding protein at one end and a rheumatoid arthritis-specific autoantigenic target at the other end. Using this dual-display phage, a much higher sensitivity in screening specificities of autoantibodies in complex serum sample has been detected compared to single-display phage system on phage ELISA. Herein, we aimed to develop a novel, rapid, and sensitive dual-display phage to detect autoantibodies presence in serum samples using quartz crystal microbalance with dissipation monitoring as a sensing platform. The vertical functionalization of the phage over the STV-modified surfaces resulted in clear frequency and dissipation shifts revealing a well-defined viscoelastic signature. Screening for autoantibodies using antihuman IgG-modified surfaces and the dual-display phage with STV magnetic bead complexes allowed to isolate the target entities from complex mixtures and to achieve a large response as compared to negative control samples. This novel dual-display strategy can be a potential alternative to the time consuming phage ELISA protocols for the qualitative analysis of serum autoantibodies and can be taken as a departure point to ultimately achieve a point of care diagnostic system.

show abstract

“…In the paper we employed our method developed earlier in Kosevich et al (1995) and Voinova et al (1997) and generalized the theory for the case of a viscoelastic thin layer under a bulk liquid (water solution, for example). Such a system has been analysed in details in our earlier works (Voinova et al, 1999(Voinova et al, , 2002Voinova, 2009) for the BAWs excited in the quartz crystal microbalance (QCM).…”

Section: The Saw and Baw Resonators -The Dynamics Of Viscoelastic Filmentioning

confidence: 99%

Modelling of the response of acoustic piezoelectric resonators in biosensor applications – Part 1: The general theoretical analysis

Voinova

2015

J. Sens. Sens. Syst.

View full text Add to dashboard Cite

Abstract. Acoustic piezoelectric resonators are widely used as precise analytical chemistry tools for the realtime monitoring of a negligibly small amount of surface-attached mass of biological components, in particular, in environmental biosensor measurements. The surface acoustic wave (SAW)-based sensors and the quartz crystal microbalance (QCM) compared in our work belong to the leading group due to their considerable advantages. These piezoelectric resonators are considered now as high-resolution analytical tools allowing researchers to discriminate between components due to the selective polymer coating on the resonator surface. The gravimetrical measurements performed with the SAW-based or QCM sensors provide the experimental data with high precision for the detection of surface mass for the thin adsorbed layer rigidly attached to the oscillator surface. The new challenge is the analysis of soft and biological materials, where the viscous losses of energy can essentially influence measured characteristics. Modelling is the important part of the analysis allowing researchers to quantify the results of the experiments. The present work provides a general theory of SH-SAW devices probing soft and biological materials. The results are compared with QCM-D operated in liquid media.

show abstract

Dynamics of viscous amphiphilic films supported by elastic solid substrates

Cited by 42 publications

References 33 publications

Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures

Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures

Real-time analysis of dual-display phage immobilization and autoantibody screening using quartz crystal microbalance with dissipation monitoring

Modelling of the response of acoustic piezoelectric resonators in biosensor applications – Part 1: The general theoretical analysis

Contact Info

Product

Resources

About