Dynamics of the Main Immunologically and Nutritionally Available Proteins of Human Milk during Lactation

Variability of lysozyme and lactoferrin bioactive protein concentrations in equine milk in relation to LYZ and LTF gene polymorphisms and expression

“…It is assumed that antimicrobial proteins obtained from milk passively protect the newborn from potential infections. Similar tendencies were observed before for human breast milk bioactive proteins . Differences observed for LYZ and LTF relative transcripts levels (mRNA) were not statistically significant between analyzed lactation periods (Table ).…”

“…Similar tendencies were observed before for human breast milk bioactive proteins. 23,24 Differences observed for LYZ and LTF relative transcripts levels (mRNA) were not statistically significant between analyzed lactation periods ( Table 3). Altogether 13 single nucleotide polymorphisms (SNPs) were found in the 5 ′ -flanking regions of the equine LYZ (nine SNPs) and LTF (four SNPs) genes (Fig.…”

Antiulcerative properties of bovine α-lactalbumin

“…a-Lactalbumin (a-La) has recently been associated with reduction of stress (Markus et al, 2000), immunomodulation (Montagne, Cuiliere, Mole, Bene, & Faure, 2000), antimicrobial activity (Pelligrini, Thomas, Bramaz, Hunziker, & Fellenberg, 1999;Pihlanto-Leppa¨la¨et al, 1999), bactericidal and apoptotic activity Svensson, Hakansson, Mossberg, Linse, & Svanborg, 2000), and antiulcer activity (Matsumoto, Shimokawa, Yshida, Toida, & Hayasawa, 2001;Ushida, Shimokawa, Matsumoto, Toida, & Hayasawa, 2003). In addition to its well known activity as enzymatic cofactor in mammary gland synthesis of lactose (Walstra, Geurts, Noomen, Jellema, & van Boekel, 1999).…”

Anticancer activity of bovine α‐lactalbumin treated with microbial transglutaminase

“…Bovine α‐lactalbumin (α‐La) plays important roles in many physiological functions such as participating in lactose synthesis in the mammary glands (Permyakov and Berliner 2000; Walstra et al. 2006), immunomodulation (Montagne et al. 2000), antimicrobial activity (Pellagrini et al.…”

“…Bovine a-lactalbumin (a-La) plays important roles in many physiological functions such as participating in lactose synthesis in the mammary glands (Permyakov and Berliner 2000;Walstra et al 2006), immunomodulation (Montagne et al 2000), antimicrobial activity (Pellagrini et al 1999), antiulcer activity (Matsumoto et al 2001;Mezzaroba et al 2006;Ushida et al 2007), prevention of cancer (de Wit 1998;Sternhagen and Allen 2001;Lee et al 2002;Madureira et al 2007), induction of cellular apoptosis (Linse 1999;Svensson et al 1999Svensson et al , 2000Permyakov and Berliner 2000;Lin et al 2008;) and reduction of stress (Markus et al 2000).…”