Dynamics of some biochemical parameters in patients with peripheral occlusive arterial disease at different periods following reconstructive surgery

Каlinin, R.E.; Евгеньевич, Калинин Роман; Suchkov, I.А.; Александрович, Сучков Игорь; Никифоров, А А; Алексеевич, Никифоров Александр; Phennikov, A S; Сергеевич, Пшенников Александр

doi:10.17816/pavlovj2012142-45

Cited by 6 publications

(1 citation statement)

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“…Open or endovascular reconstructive procedures may promote hypercoagulability and endothelial dysfunction, which is reflected in increased activities of vWF, PAI-1, elevated levels of sEPCR, and low levels of NO metabolites at 3 months after the procedure. Our previous studies have shown that NO metabolite levels decrease in accordance with the progression of ischemia in patients with atherosclerotic PAD [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Каlinin

Suchkov

Mzhavanadze

et al. 2021

Vasc Specialist Int

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Purpose We aimed to evaluate the impact of intrinsic coagulation factors and hemostatic markers of endothelial dysfunction on complications in patients with atherosclerotic peripheral arterial disease (PAD). Methods Materials and This prospective study enrolled 120 PAD patients at Fontaine stages 2b to 3 who underwent open surgical, endovascular, or conservative treatment. Coagulation factors (FVIII, FIX, and FXI) and endothelial hemostatic markers, including von Willebrand factor (vWF) activity and level, soluble endothelial protein C receptor, and plasminogen activator inhibitor-1 (PAI-1) levels, were assessed. Results At 3 months after open bypass grafting, activity of FVIII significantly increased from a median of 175% to 233% (P<0.001). At 3 months after endovascular treatment, the activities of FVIII, FIX, and FXI significantly increased from medians of 157%, 180%, and 156% to 184%, 218%, and 181%, respectively (P<0.05). Six patients with increased FVIII activity developed bypass graft thrombosis. Four patients in the endovascular group and three patients in the conservative treatment group with increased activity of vWF developed myocardial infarction (P=0.049). The subjects who developed restenosis had increased vWF activity (P=0.023) and decreased nitric oxide metabolite levels (P=0.003). Three subjects who received conservative treatment and developed PAD progression at 12 months had increased PAI-1 activity (P=0.028). Conclusion Patients with advanced PAD had a hypercoagulable status, and performance of open or endovascular revascularization was associated with further hypercoagulability. Increased activity of coagulation factors and altered levels of hemostatic markers of endothelial dysfunction were associated with PAD complications such as graft thrombosis, myocardial infarction, disease progression, and restenosis.

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Section: Discussionmentioning

confidence: 99%