Dynamics of seasonal parameters of external respiration and gas exchange in the population of Northeast Russia

Maksimov, A. L.; Averyanova, I. V.; Vdovenko, S. I.

doi:10.1134/s0362119715070117

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…The components of PM 2.5 also exhibit variety in different seasons and cities. Accordingly, the composition, size, biological properties, and physical properties of particles are related to the region, season, and change over time [ 1 , 2 ]. Differences in pollution levels are generated from various pollution sources.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Cho

Hsieh

Tsai

et al. 2018

IJERPH

148

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Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM2.5), and the components may also have different effects on people. The pathogenesis of PM2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM2.5 in several diseases. Numerous studies show that PM2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM2.5-induced disease.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Cho

Hsieh

Tsai

et al. 2018

IJERPH

148

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“…8 It should be mentioned that, among the different anthropogenicgenerated air pollutants, PM is considered one of the most toxic to human health and it has been indeed correlated with global increased mortality and morbidity. 9,10 The ability of PM to affect health is mainly due to its complex and diversified composition (which varies based on the geographical area and seasons) 11,12 as well as its size. Based on aerodynamic equivalent diameter (AED), PM can be divided into three different fractions that influence their lung absorption: coarse particles of circa 10 μm diameter are filtered by the proximal airway; fine particles ranging between 2.5 and 0.1 μm can be inhaled into the gas exchange area of peripheral airway 13 ; and ultrafine particles (UFP) with an AED of 0.1 μm.…”

mentioning

confidence: 99%

Gastrointestinal tissue as a “new” target of pollution exposure

Pambianchi¹,

Pecorelli²,

Valacchi

2021

IUBMB Life

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Airborne pollution has become a leading cause of global death in industrialized cities and the exposure to environmental pollutants has been demonstrated to have adverse effects on human health. Among the pollutants, particulate matter (PM) is one of the most toxic and although its exposure has been more commonly correlated with respiratory diseases, gastrointestinal (GI) complications have also been reported as a consequence to PM exposure. Due to its composition, PM is able to exert on intestinal mucosa both direct damaging effects, (by reaching it either via direct ingestion of contaminated food and water or indirect inhalation and consequent macrophagic mucociliary clearance) and indirect ones via generation of systemic inflammation. The relationship between respiratory and GI conditions is well described by the lung‐gut axis and more recently, has become even clearer during coronavirus disease 2019 (COVID‐19) pandemic, when respiratory symptoms were associated with gastrointestinal conditions. This review aims at pointing out the mechanisms and the models used to evaluate PM induced GI tract damage.

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“…Exposure to PM owing to air pollution and the subsequent health effects are among the most common global health risks, especially in Northeast Asia (Bai et al 2018;GBD 2015Risk Factors Collaborators 2016. The composition, size, and biological and physical properties of PM vary with the changes in region, season, and time (Maksimov et al 2013). Therefore, it is crucial to identify toxic constituents in PM according to these factors and investigate their associated health effects (Bai et al 2018;Pardo et al 2018;Shi et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

Lee

Jeong

et al. 2021

Environ Sci Pollut Res

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Atmospheric particulate matter (PM) contains different components that can elicit varying adverse health effects in humans and animals. Studies on PM toxicity and its underlying mechanisms in the middle ear are limited, and they generally use a PM standard. However, as PM composition varies temporally and geographically, it is crucial to identify the toxic PM constituents according to season and region and investigate their associated health effects. Thus, we sought to determine whether PM induces cytotoxicity and inflammatory factor and reactive oxygen species (ROS) generation in human middle ear epithelial cells obtained from patients with otitis media. The cells were treated with both standard urban PM and PM directly captured from the atmosphere in Wonju City. The association between mitochondrial dysfunction and PM was investigated. PM exposure significantly increased COX-2 and TNF-α mRNA expression, increased ROS generation, induced inflammatory responses, and caused abnormalities in mitochondrial motility and function. Furthermore, PM induced cell apoptosis, which consequently reduced cell survival, particularly at the concentration of 100 μg/mL. Overall, our study provides new insights into the toxic effects of standard and atmospheric PM on middle ear cell line.

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Dynamics of seasonal parameters of external respiration and gas exchange in the population of Northeast Russia

Cited by 3 publications

References 1 publication

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Gastrointestinal tissue as a “new” target of pollution exposure

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

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