Dynamics of oral microbiome acquisition in healthy infants: A pilot study

Li, Yihong; Saraithong, Prakaimuk; Zhang, Lanxin; Dills, Ashley; Paster, Bruce J.; Xiao, Jin; Wu, Tong Tong; Jones, Zachary M.

doi:10.3389/froh.2023.1152601

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…From another perspective on the oral microbiota and health, a recent report investigating the influence of the maternal oral microbiota on the formation of the oral microbiota in healthy infants suggested that infants may be colonized with an oral microbiota different from that of their mothers at birth. Further research is needed to determine how establishing an early oral microbiota influences health over time [ 51 ].…”

Section: Overview Of Factors Affecting the Oral Microbiotamentioning

confidence: 99%

Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease

Nagakubo,

Kaibori

2023

Microorganisms

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Recent advances in metagenomic analyses have made it easier to analyze microbiota. The microbiota, a symbiotic community of microorganisms including bacteria, archaea, fungi, and viruses within a specific environment in tissues such as the digestive tract and skin, has a complex relationship with the host. Recent studies have revealed that microbiota composition and balance particularly affect the health of the host and the onset of disease. Influences such as diet, food preferences, and sanitation play crucial roles in microbiota composition. The oral cavity is where the digestive tract directly communicates with the outside. Stable temperature and humidity provide optimal growth environments for many bacteria. However, the oral cavity is a unique environment that is susceptible to pH changes, salinity, food nutrients, and external pathogens. Recent studies have emphasized the importance of the oral microbiota, as changes in bacterial composition and balance could contribute to the development of systemic diseases. This review focuses on saliva, IgA, and fermented foods because they play critical roles in maintaining the oral bacterial environment by regulating its composition and balance. More attention should be paid to the oral microbiota and its regulatory factors in oral and systemic health.

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Section: Overview Of Factors Affecting the Oral Microbiotamentioning

confidence: 99%

Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease

Nagakubo,

Kaibori

2023

Microorganisms

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“…Genera such as Neisseria, Gemella, Granulicatella, Veillonella, Haemophilus, and Prevotella have been reported to increase at 3–6 months ( Cephas et al, 2011 ; Dzidic et al, 2018 ). With age, the infant oral microbiome increases in complexity and richness ( Sulyanto et al, 2019 ; Ramadugu et al, 2021 ; Li et al, 2023 ).…”

Section: Composition and Temporal Development Of The Infant Oral Micr...mentioning

confidence: 99%

Impact of breastfeeding and other early-life factors on the development of the oral microbiome

Arishi,

Lai,

Geddes

et al. 2023

Front. Microbiol.

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The oral cavity is home to the second most diverse microbiome in the human body. This community contributes to both oral and systemic health. Acquisition and development of the oral microbiome is a dynamic process that occurs over early life; however, data regarding longitudinal assembly of the infant oral microbiome is scarce. While numerous factors have been associated with the composition of the infant oral microbiome, early feeding practices (breastfeeding and the introduction of solids) appear to be the strongest determinants of the infant oral microbiome. In the present review, we draw together data on the maternal, infant, and environmental factors linked to the composition of the infant oral microbiome, with a focus on early nutrition. Given evidence that breastfeeding powerfully shapes the infant oral microbiome, the review explores potential mechanisms through which human milk components, including microbes, metabolites, oligosaccharides, and antimicrobial proteins, may interact with and shape the infant oral microbiome. Infancy is a unique period for the oral microbiome. By enhancing our understanding of oral microbiome assembly in early life, we may better support both oral and systemic health throughout the lifespan.

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“…The human microbiome is a complex ecosystem of microorganisms, undergoing substantial changes from birth to adulthood (1). Among the various microbiomes, the oral microbiome is one of the most intricate one, comprising over 700 identified species (2,3). The oral cavity is a primary entry point for the colonization of both oral and gastrointestinal tract (GIT), making it an accessible site for assessing microbial communities.…”

Section: Introductionmentioning

confidence: 99%

First-Year Dynamics of the Anaerobic Microbiome and Archaeome in Infants Oral and Gastrointestinal Systems

Neumann,

Mohammadzadeh,

Woh

et al. 2024

Preprint

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Recent research provides new insights into the early establishment of the infant gut microbiome, emphasizing the influence of breastfeeding on the development of gastrointestinal (GIT) microbiomes. In our study, we longitudinally examined the taxonomic and functional dynamics of the oral and GIT microbiomes of healthy infants (n=30) in their first year, focusing on the often over-looked aspects, the development of archaeal and anaerobic microbiomes. Breastfed (BF) infants exhibit a more defined transitional phase in their oral microbiome compared to non-breastfed (NBF) infants, marked by a decrease in Streptococcus and the emergence of anaerobic genera such as Granulicatella. This phase, characterized by increased alpha diversity and significant changes in beta diversity, occurs earlier in NBF infants (months 1-3) than in BF infants (months 4-6), suggesting that breastfeeding supports later, more defined microbiome maturation. We demonstrated the presence of archaea in the infant oral cavity and GIT microbiome from early infancy, with Methanobrevibacter being the predominant genus. Still, transient patterns show that no stable archaeome is formed. The GIT microbiome exhibited gradual development, with BF infants showing increased diversity and complexity between months 3 and 8, marked by anaerobic microbial networks. NBF infants displayed complex microbial cooccurrence patterns from the start. Those strong differences between BF and NBF infants GIT microbiomes are less pronounced on functional levels than on taxonomic level. Overall, the infant microbiome differentiates and stabilizes over the first year, with breastfeeding playing a crucial role in shaping anaerobic microbial networks and overall microbiome maturation.

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Dynamics of oral microbiome acquisition in healthy infants: A pilot study

Cited by 3 publications

References 57 publications

Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease

Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease

Impact of breastfeeding and other early-life factors on the development of the oral microbiome

First-Year Dynamics of the Anaerobic Microbiome and Archaeome in Infants Oral and Gastrointestinal Systems

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