Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen

Deryugina, А. V.; Danilova, D. A.; Skokova, A. A.; Brichkin, Yu.D.; Пичугин, В.В.; Медведев, А. П.; Ryazanov, М.V.; Федоров, С. А.

doi:10.1007/s10517-022-05595-z

Cited by 2 publications

(1 citation statement)

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“…CHF was induced as previously described [ 15 ] by intraperitoneal injection of 1% adrenaline (Epinephrine hydrochloride, Federal State Unitary Enterprise “Moscow Endocrine Plant”, Moscow, Russian Federation) at 0.3 mg/kg three times every 48 h [ 16 ]. The consequences of chronic epinephrine exposure include biventricular heart failure and ventricular remodeling, with clinical hyperadrenergic conditions, chronic heart failure develops.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure

Deryugina

Danilova

Пичугин

et al. 2023

Life

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Molecular hydrogen has an anti-inflammatory and cardioprotective effect, which is associated with its antioxidant properties. Erythrocytes are subjected to oxidative stress in pathologies of the cardiovascular system, which is the cause of a violation of the gas transport function of blood and microcirculation. Therefore, our aim was to investigate the effects of H2 inhalation on the functional states of red blood cells (RBCs) in chronic heart failure (CHF) in rats. The markers of lipid peroxidation, antioxidant capacity, electrophoretic mobility of erythrocytes (EPM), aggregation, levels of adenosine triphosphate (ATP) and 2,3-diphosphoglyceric acid (2,3-DPG), hematological parameters were estimated in RBCs. An increase in EPM and a decrease in the level of aggregation were observed in groups with multiple and single H2 application. The orientation of lipoperoxidation processes in erythrocytes was combined with the dynamics of changes in oxidative processes in blood plasma, it was observed with both single and multiple exposures, although the severity of the changes was greater with multiple H2 inhalations. Probably, the antioxidant effects of molecular hydrogen mediate its metabolic action. Based on these data, we conclude the use of H2 improves microcirculation and oxygen transport function of blood and can be effective in the treatment of CHF.

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Section: Methodsmentioning

confidence: 99%