1986
DOI: 10.1016/0016-5085(86)90184-8
|View full text |Cite
|
Sign up to set email alerts
|

Dynamics of hepatic glycosaminoglycan accumulation in murine Schistosoma japonicum infection

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
7
0

Year Published

1987
1987
1992
1992

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 13 publications
(7 citation statements)
references
References 30 publications
0
7
0
Order By: Relevance
“…In order of decreasing concentrations, they are heparan sulfate (more than 60% of total GAG), dermatan sulfate and chondroitin-4,6-sulfate isomers (5-8, 12). The amount of sulfated PGs in normal liver tissue is low but in pathologic states such as fibrosis (6)(7)(8)13) and HCC (14,15) their concentration increases several times and the profile of GAGs changes, dramatically, leading to a strong absolute and relative increase of dermatan sulfate and chondroitin sulfate and a fractional decrease of heparan sulfate (lower than 50% (25). The core protein sequences of the members of this family of leucine-rich-motif extracellular proteins have been postulated to play a role in molecular interactions and specifically to facilitate the binding of these macromolecules to other matrix components such as collagens (25-29) and fibronectins (30-32).…”
Section: (Hepatology 1992; 16~204-2 16)mentioning
confidence: 99%
See 1 more Smart Citation
“…In order of decreasing concentrations, they are heparan sulfate (more than 60% of total GAG), dermatan sulfate and chondroitin-4,6-sulfate isomers (5-8, 12). The amount of sulfated PGs in normal liver tissue is low but in pathologic states such as fibrosis (6)(7)(8)13) and HCC (14,15) their concentration increases several times and the profile of GAGs changes, dramatically, leading to a strong absolute and relative increase of dermatan sulfate and chondroitin sulfate and a fractional decrease of heparan sulfate (lower than 50% (25). The core protein sequences of the members of this family of leucine-rich-motif extracellular proteins have been postulated to play a role in molecular interactions and specifically to facilitate the binding of these macromolecules to other matrix components such as collagens (25-29) and fibronectins (30-32).…”
Section: (Hepatology 1992; 16~204-2 16)mentioning
confidence: 99%
“…In order of decreasing concentrations, they are heparan sulfate (more than 60% of total GAG), dermatan sulfate and chondroitin-4,6-sulfate isomers (5-8, 12). The amount of sulfated PGs in normal liver tissue is low but in pathologic states such as fibrosis (6)(7)(8)13) and HCC (14,15) their concentration increases several times and the profile of GAGs changes, dramatically, leading to a strong absolute and relative increase of dermatan sulfate and chondroitin sulfate and a fractional decrease of heparan sulfate (lower than 50%). Fat-storing cells (FSCs) (also called perisinusoidal lipocytes, vitamin A-storing cells or It0 cells [16,171) and their transformed counterpart (i.e.…”
mentioning
confidence: 99%
“…Aliquots of 50 granulomas were removed by Past,eur pipet with the aid of a dissecting microscope (11 j and used for subsequent studies. Thin liver slices from infected and noninfected mice were obtained as described previously (12 (13,14). As shown in previous studies (14), radioactivity isolated in this fashion is associated with hepatic glycosaminoglycans.…”
Section: Isolation Of Hepatic Granulomas and Liver Slicesmentioning
confidence: 99%
“…Thin liver slices from infected and noninfected mice were obtained as described previously (12 (13,14). As shown in previous studies (14), radioactivity isolated in this fashion is associated with hepatic glycosaminoglycans. The digests were chilled and treated with 10% trichloroacetic acid to remove the protein.…”
Section: Isolation Of Hepatic Granulomas and Liver Slicesmentioning
confidence: 99%
“…Neither glycosaminoglycan synthesis nor secretion in cultures of parenchymal and other non-parenchymal cells were evaluated under comparable conditions. Information on the relative contribution of the various cell types to hepatic proteoglycan and hyaluronate synthesis will be important since under pathological conditions like liver fibrosis (25)(26)(27)(28) and hepatocellular carcinoma (29,30), both the total glycosaminoglycan content and the pattern of suiphated and non-sulphated glycosaminoglycans chanige greatly. In the present study we attempted to compare the synthesis, secretion, and molecular profile of glycosaminoglycans of hepatocytes, fat-storing cellSj and Kupffer cells kept in culture under largely identical conditions.…”
Section: Introductionmentioning
confidence: 99%