1992
DOI: 10.1002/hep.1840160131
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Biglycan and Decorin Gene Expression in Normal and Fibrotic Rat Liver: Cellular Localization and Regulatory Factors

Abstract: The expression of genes encoding the core proteins of the novel small chondroitin/dermatan sulfate proteoglycans decorin and biglycan was studied in the livers of normal rats and in liver tissue during fibrogenesis induced by prolonged bile-duct ligation and thioacetamide poisoning. The cell types responsible for the expression of these transcripts and some key regulatory factors were identified. Both biglycan and decorin messenger RNAs were detected in normal liver tissue. Their relative abundance increased s… Show more

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Cited by 85 publications
(32 citation statements)
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“…58 In MFBs, decorin and biglycan, which are already present at relatively high levels in untreated cells, cannot be increased further by TGF-␤1. Another cytokine, tumor necrosis factor ␣, however, can superinduce both mRNAs in MFBs.…”
Section: Discussionmentioning
confidence: 97%
“…58 In MFBs, decorin and biglycan, which are already present at relatively high levels in untreated cells, cannot be increased further by TGF-␤1. Another cytokine, tumor necrosis factor ␣, however, can superinduce both mRNAs in MFBs.…”
Section: Discussionmentioning
confidence: 97%
“…Both biglycan and decorin are expressed in the rat liver, albeit at different basal levels, with an increase paralleling the development of fibrosis [20]. Eumican is also expressed in the rat liver, but at quite constant levels throughout the fibrotic process.…”
Section: Discussionmentioning
confidence: 99%
“…[22][23][24][25][26] HA is a prominent component of the expanded extracellular matrix in the injured liver, and is markedly overproduced in experimental liver injury. 42 Of note, HA levels are also elevated in patients with alcoholic hepatitis and may correlate with the clinical severity of liver disease.…”
Section: Discussionmentioning
confidence: 99%
“…In chronically injured liver, matrix components produced in increased quantities include interstitial collagens, laminins, fibronectins, proteoglycans and glycosaminoglycans (heparan sulfate, chondroitin sulfate). [22][23][24][25][26] Among the glycosaminoglycan components produced in excess in fibrosing liver disease is HA. 23 Several studies have established that HA is the principal ligand for CD44.…”
mentioning
confidence: 99%