Dynamics of essential amino acids plasma levels in patients with sepsis treated by the extracorporeal blood purification methods

Abstract

Extracorporeal blood purification (EBP) is one of the trends of effective sepsis therapy. Some disadvantages of this method such as a possible reduction of plasma levels of different important metabolites are described. It is known that sepsis disorders of amino acid metabolism are manifested in microcirculation interruptions, the decreased immune response and the increased mortality. The aim of the study is to investigate the EBP effect on the essential amino acid plasma levels in patients diagnosed with sepsis. We selected 38 patients diagnosed with sepsis. Standard treatment protocols of plasma filtration, hemofiltration, and hemadsorption with various sorbents were used. We revealed a significant decrease in the levels of valine, methionine, tryptophan, isoleucine, phenylalanine, leucine, and lysine in patients who underwent hemadsorption by the sorbent “Proteasosorb”. Hemadsorption by the sorbent “Proteasosorb” has the greatest effect on the levels of amino acids.