Dynamics of driftless preconcentration using ion concentration polarization leveraged by convection and diffusion

Baek, Seong-Ho; Choi, Jihye; Son, Seok Young; Kim, Junsuk; Hong, Seongjun; Kim, Hee Chan; Chae, Jong Hee; Lee, Hyomin; Kim, Sung Jae

doi:10.1039/c9lc00508k

Cited by 15 publications

(14 citation statements)

References 75 publications

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“…demonstrated the abnormal shape of preconcentrated samples (plug or dumb‐bell shape) by DNA experiments of different lengths. The results showed that this will provide new insights into the basic electrodynamic dynamics of molecules in the ICP platform …”

Section: Applications Of Ion Transport Based On Icpmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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Lab-on-a-chip has been used widely in rapid, high-throughput and low-consumption analysis of samples in biochemistry. The ion concentration polarization (ICP) produced by ion-selective transport of nanochannels provides a novel solution for problems in ultra-low concentration sample detection, systems biology and desalination. This paper reviews the applications of ion transport based on the principle of ICP in micro-nanofluidic systems. First, the fundamental governing equations of ICP are described. Then, the applications of nano-electrokinetic ion enrichment and ion current rectification (ICR) are introduced. Nano-electrokinetic ion enrichment is used mainly in the fields of molecular enrichment, ultra-low concentration sample detection and seawater desalination. ICR is applied mainly to the sensitive detection of analytical substances such as proteins, nucleic acids and small molecules. The application of ion transport based on ICP principle is summarized and the possible directions worthy of further research are proposed.

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Section: Applications Of Ion Transport Based On Icpmentioning

confidence: 99%

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Han

Chen

2019

J of Chemical Tech & Biotech

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“…Recently, separation and preconcentration of biomolecules has been demonstrated with paper-based ion concentration polarization (ICP) platform. Since conventional ICP preconcentration method has several benefits such as high preconcentration factor and no need of complex buffer exchange, ICP has been extensively studied for the selective preconcentration of biomolecules [8][9][10][11][12]. However, because typical ICP platform required an external electrical field for performing the separation, paper-based ICP separator also needed an external power source and cause the methods to be against to the original concept of μPADs.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous diffusiophoretic separation in paper-based microfluidic device

Lee

Kim

2020

Micro and Nano Syst Lett

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Microfluidic paper-based analytical devices (μPADs) for separating particles have been playing a key role for point-ofcare diagnostics in the area of remote settings. While splendid separation methods using μPADs have been explosively developed, they still require external devices inducing external field. In this work, the spontaneous separation method in μPADs was suggested by leveraging convective flow (the imbibition of paper and nanoporous medium) and diffusiophoresis by ion exchange medium. Especially, the paper's fast imbibition was utilized as driving particles at the first stage, which results in fast overall processing in contrast to the spontaneous separation method of microfluidic chip integrated with only ion exchange medium. Therefore, our novel spontaneous selective preconcentration method based on μPADs would have key potential to be used in portable point-of-care devices in remote settings.

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“…[25][26][27] The electric field gradient associated with ICP has also been used for dielectrophoresis of cells, [14,28,29] salt water desalination, [17,[30][31][32] and analyte enrichment. [33] Analytes such as charged fluorophores, [1,34,35] microparticles, [23,36] and proteins [37,38] have all been enriched, with up to a million-fold enrichment factor in one case. [16] A few years ago, our group introduced an electrochemical variant of ICP called faradaic ICP (fICP).…”

Section: Introductionmentioning

confidence: 99%

“…The electric field gradient associated with ICP has also been used for dielectrophoresis of cells, salt water desalination, and analyte enrichment . Analytes such as charged fluorophores, microparticles, and proteins have all been enriched, with up to a million‐fold enrichment factor in one case …”

Section: Introductionmentioning

confidence: 99%

Cation‐Specific Electrokinetic Separations Using Prussian Blue Intercalation Reactions

et al. 2020

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We report a new approach for forming ion depletion zones (IDZs) using intercalation reactions at an electrochemically controlled Prussian blue (PB) film. The experiments described here were performed using a microfluidic device, wherein a charged fluorophore in solution was used as a proxy to monitor IDZ formation. In the presence of K + , intercalation reactions proceed readily to form an IDZ, and thus enrich the fluorophore up to 37-fold. In the presence of the larger hydrated Li + or tetrabutylammonium (TBA +) ions, however, ion intercalation proceeded less quickly than with K +. Slower ion intercalation resulted in a weaker IDZ and correspondingly lower enrichment factors of eight-and six-fold, respectively. These results are significant because they show that PB intercalation reactions selectively form an IDZ. Accordingly, we anticipate that these findings will lead to a better understanding and further interesting applications of intercalation materials like PB for efficient and selective enrichment and separations.

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Dynamics of driftless preconcentration using ion concentration polarization leveraged by convection and diffusion

Abstract: A nanoelectrokinetic study reveals that the Peclet number determines the shape of preconcentrated analytes, as either plug or dumbbell shaped.

Cited by 15 publications

References 75 publications

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

A review: applications of ion transport in micro‐nanofluidic systems based on ion concentration polarization

Spontaneous diffusiophoretic separation in paper-based microfluidic device

Cation‐Specific Electrokinetic Separations Using Prussian Blue Intercalation Reactions

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