Dynamics of controlled release of chlorpyrifos from swelling and eroding biopolymeric microspheres of calcium alginate and starch

Roy, Anamika; Bajpai, Jaya; Bajpai, A. K.

doi:10.1016/j.carbpol.2008.10.013

Cited by 115 publications

(71 citation statements)

References 30 publications

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“…This was due to formation of compact polymeric networks in the beads which not only restrained the mobility of polymeric chains, but also brought about shrinkage in the matrix pores. The similar observation has been observed by Roy et al (2009) where the increase in content of gelatin in alginate-gelatin beads decreased the release of cypermethrin insecticide from the formulations. Similar results have also been observed by other workers (Kulkarni et al 2000).…”

Section: +3supporting

confidence: 87%

“…Hence, it is possible to control the rate of pesticide release by suitably modifying and adjusting the experimental protocol. The reaction parameters for the synthesis of beads such as concentrations of crosslinker, pesticide, alginate to gelatin ratio, and temperature affect the release profiles of pesticide from the controlled-release systems (Roy et al 2009). …”

Section: Fernándezmentioning

confidence: 99%

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Polysaccharides as safer release systems for agrochemicals

Campos

Oliveira

Fraceto

et al. 2014

Agron. Sustain. Dev.

267

175

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Agrochemicals are used to improve the production of crops. Conventional formulations of agrochemicals can contaminate the environment, in particular in the case of intensive cropping. Hence, there is a need for controlledrelease formulations of agrochemicals such as polysaccharides to reduce pollution and health hazards. Natural polysaccharides are hydrophilic, biodegradable polymers. This article reviews the use of polysaccharides in the form of micro-and nanoparticles, beads and hydrogels. The main points are: (1) slow release formulations minimize environmental impact by reducing agrochemical leaching, volatilization and degradation. For example, 50 % of the encapsulated insecticide chlorpyrifos is released in 5 days, whereas free chlorpyrifos is released in 1 day. (2) Slow release formulations increase the water-holding capacity of soil. (3) Slow release formulations better control weeds in the long run. (4) Polymer-clay formulations store ionic plant nutrients. (5) Polymer hydrogel formulations reduce compaction, erosion, and water run-off. They increase soil permeability and aeration, infiltration rates, and microbial activity, and, in turn, plant performance. In conclusion, polysaccharide formulations can be used for safer use of agrochemicals.

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Section: +3supporting

confidence: 87%

Section: Fernándezmentioning

confidence: 99%

Polysaccharides as safer release systems for agrochemicals

Campos

Oliveira

Fraceto

et al. 2014

Agron. Sustain. Dev.

267

175

View full text Add to dashboard Cite

show abstract

“…The spectral peak at 3618 cm À1 implies for the N-H stretching while the bands observed at 1681 cm À1 confirm the ÀNH bending/carboxylate ion stretching and thus suggest for the presence of insulin in the drug-loaded nanoparticles [31]. The spectral peaks also suggest for the presence of alginate as evident form the O-H stretching of hydroxyl at 3618 cm À1 and C(¼O) 2 stretching of carboxylate ion at 1591 cm À1 , respectively [32]. The morphology of the alginate nanoparticles is depicted in Figure 2 and it clearly shows that the particles have identical dimensions and regular shapes.…”

Section: Discussionmentioning

confidence: 76%

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Goswami¹,

Bajpai²,

Bajpai³

2012

Journal of Experimental Nanoscience

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In the present investigation, alginate nanoparticles have been prepared and characterised by various techniques such as FTIR, SEM, particle size analysis and surface charge measurements. It was found from both the SEM and particle size analysis that average size of the particle was about 40 nm. The particles were loaded with insulin and the release kinetics of insulin was studied in PBS medium. The results indicated that when percent loading increases from 11.7 to 38.9, the released amount of insulin increased from 18% to 60% of the loaded drug. The effect of composition of nanoparticles, pH and temperature of the release medium was examined on the amount of released insulin. It was observed when that amount of alginate in the feed mixture was varied from 1.0 to 2.0 g, the prepared nanoparticles showed a decreasing tendency to release insulin. Similarly, upon increasing the concentration of crosslinker in the range 0.5-1.1 mM, the release of insulin constantly decreased. The chemical stability of the loaded drug was assessed especially under highly acidic conditions of artificial gastric juice and it was noticed that even in harsh acidic environment (pH 1.2) the insulin remains chemically stable. The in vitro blood compatibility of nanoparticles was also investigated and it was found that for a definite composition of nanoparticles, protein adsorption and percent haemolysis were minimum which suggested for an optimum blood compatibility of alginate nanoparticles of definite composition. Thus, it can be conclusively stated that the calcium alginate nanoparticles prepared by emulsion crosslinking method show potential to be developed as oral formulation for insulin delivery.

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“…Almost all starch microparticles have been prepared by an emulsification-cross-linking reaction [17][18][19][20]. The preparation of alginate/starch blended microparticles has been reported by Roy et al [21]. However, no information on SF/starch blended microparticles has been published.…”

Section: Introductionmentioning

confidence: 99%

Morphology and thermal stability of silk fibroin/starch blended microparticles

Baimark¹,

Srisa-ard²,

Srihanam³

2010

Express Polym. Lett.

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Abstract. In the present study biodegradable microparticles of silk fibroin (SF)/starch blends were prepared by a simple water-in-oil emulsion solvent diffusion technique. SF/starch blended solution and ethyl acetate were used as water and oil phases, respectively. The influence of SF/starch ratios on characteristics of the blended microparticles was investigated. The SF conformation of microparticle matrices from FTIR analysis was changed from random coil to β-sheet form by blending with starch. The blended microparticles had lower dissolution in water than those of SF and starch microparticles. The 1/3 (w/w) SF/starch blended microparticles exhibited the lowest dissolution. The SF and starch microparticles showed irregular and deflated shapes, respectively. The blended microparticles were nearly spherical in shapes and smaller sizes. Thermal stability of the blended microparticles slightly increased with the starch blended ratio. The results suggested that SF conformational transition, thermal stability, morphology and dissolution of the blended microparticles can be adjusted by varying the blended ratio.

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Dynamics of controlled release of chlorpyrifos from swelling and eroding biopolymeric microspheres of calcium alginate and starch

Cited by 115 publications

References 30 publications

Polysaccharides as safer release systems for agrochemicals

Polysaccharides as safer release systems for agrochemicals

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Morphology and thermal stability of silk fibroin/starch blended microparticles

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