Dynamics and rheology of vesicle suspensions in wall-bounded shear flow

Lamura, A.; Gompper, Gerhard

doi:10.1209/0295-5075/102/28004

Cited by 23 publications

(43 citation statements)

References 35 publications

(72 reference statements)

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“…In this paper, we will give an overview of the numerical results obtained on the basis of a two-dimensional vesicle model, which is characterized by the presence of thermal membrane undulations as well as of thermal noise which implies translational Brownian motion 13 . Both these features are missing in the other numerical approaches.…”

Section: Introductionmentioning

confidence: 99%

Rheological Properties of Sheared Vesicle and Cell Suspensions

Lamura

Gompper

2015

Procedia IUTAM

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Numerical simulations of vesicle suspensions are performed in two dimensions to study their dynamical and rheological properties. An hybrid method is adopted, which combines a mesoscopic approach for the solvent with a curvature-elasticity model for the membrane. Shear flow is induced by two counter-sliding parallel walls, which generate a linear flow profile. The flow behavior is studied for various vesicle concentrations and viscosity ratios between the internal and the external fluid. Both the intrinsic viscosity and the thickness of depletion layers near the walls are found to increase with increasing viscosity ratio.

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Section: Introductionmentioning

confidence: 99%

Rheological Properties of Sheared Vesicle and Cell Suspensions

Lamura

Gompper

2015

Procedia IUTAM

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“…Research on vesicles, capsules, and RBCs under flow is very active, regarding both their dynamics [10, and their rheology [10,20,22,33,36,[44][45][46][47][48][49].…”

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Prediction of Anomalous Blood Viscosity in Confined Shear Flow

et al. 2014

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Red blood cells play a major role in body metabolism by supplying oxygen from the microvasculature to different organs and tissues. Understanding blood flow properties in microcirculation is an essential step towards elucidating fundamental and practical issues. Numerical simulations of a blood model under a confined linear shear flow reveal that confinement markedly modifies the properties of blood flow. A nontrivial spatiotemporal organization of blood elements is shown to trigger hitherto unrevealed flow properties regarding the viscosity η, namely ample oscillations of its normalized value ½η ¼ ðη − η 0 Þ=ðη 0 ϕÞ as a function of hematocrit ϕ (η 0 ¼ solvent viscosity). A scaling law for the viscosity as a function of hematocrit and confinement is proposed. This finding can contribute to the conception of new strategies to efficiently detect blood disorders, via in vitro diagnosis based on confined blood rheology. It also constitutes a contribution for a fundamental understanding of rheology of confined complex fluids. Introduction.-Blood flow in microcirculation is essential for delivery of nutrients and removal of metabolic waste products to or from tissues. These functions are ensured by proper regulation of blood flow down to the capillary level. One of the main factors controlling capillary circulation is microvascular resistance to blood flow. This effect, in spite of extensive investigation, is still to be fully elucidated, and some fundamental issues remain open. Blood is to good approximation a suspension of red blood cells (RBCs). Blood rheology is dictated by dynamics of RBCs and their interaction with blood vessel walls. A significant research effort has been devoted so far to macroscopic rheology [1,2]. Most of the research on rheology in confined geometries has focused on the famous Fahraeus-Lindqvist (FL) effect [3][4][5] (see recent review [6]), where confinement has been shown to strongly affect the rheology, with a decrease in apparent viscosity as the diameter of a vessel decreases. These advances have not exhausted yet the intricate behavior inherent to rheology of confined blood, as reported in this Letter.A property that is commonly of interest for nonconfined suspensions is the viscosity as a function of the volume fraction ϕ, ηðϕÞ. In the dilute regime, i.e., when hydrodynamic interactions between suspended entities can be neglected, η takes the generic form η ¼ η 0 ð1 þ a 1 ϕÞ, where η 0 is the viscosity of the suspending fluid and a 1 is a quantity (the so-called intrinsic viscosity), that depends, in general, on the properties of the suspension. For example, for rigid particles, a 1 is just a universal number and is equal to 5=2; this is the famous Einstein result [7,8]. a 1 was calculated by Taylor [9] for emulsions, and extended to vesicle suspensions (a blood model) quite recently [10]. When the volume fraction increases, hydrodynamic interactions among suspended

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“…[33][34][35] The loss in symmetry enhances the objects to undergo cross-streamline migration which is generally directed away from the wall and, in Poiseuille flow, directed towards the centerline of the flow field. 25,33,34 In blood flow the effect is known as Fåhraeus-Lindqvist effect 36 and drives red blood cells (RBCs) towards the centerline of the blood vessel and eventually causes a reduction of the apparent viscosity. 35 The effect is also leading to margination of leukocytes and blood platelets.…”

Section: A Non-inertial Hydrodynamic Liftmentioning

confidence: 99%

“…[23][24][25] The strength of the effect and therefore the drift velocity depends on size and deformability of the cells and differs for melanoma and red blood cells. 26,27 The larger melanoma cells experience a stronger lift effect than the RBCs and migrate to the center of the channel, while the RBCs stay at lower heights.…”

Section: -4mentioning

confidence: 99%

“…The sorting process takes advantage of size and deformability as intrinsic biomarkers and is induced by a hydrodynamic effect at very low Reynolds numbers, the so called non-inertial hydrodynamic lift. [23][24][25][26][27][28][29] To characterize our non-inertial hydrodynamic lift induced cell sorting (NILICS) device, we use the MV3-melanoma cell line. The MV3-cell line is a relatively small (average diameter: (14 6 2) lm), highly tumorigenic and metastatic human skin cancer line.…”

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Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift

Geislinger

Franke

2013

Biomicrofluidics

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We demonstrate the method of non-inertial lift induced cell sorting (NILICS), a continuous, passive, and label-free cell sorting approach in a simple single layer microfluidic device at low Reynolds number flow conditions. In the experiments, we exploit the non-inertial lift effect to sort circulating MV3-melanoma cells from red blood cell suspensions at different hematocrits as high as 9%. We analyze the separation process and the influence of hematocrit and volume flow rates. We achieve sorting efficiencies for MV3-cells up to E MV3 ¼ 100% at Hct ¼ 9% and demonstrate cell viability by recultivation of the sorted cells. V C 2013 AIP Publishing LLC. [http://dx

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Dynamics and rheology of vesicle suspensions in wall-bounded shear flow

Cited by 23 publications

References 35 publications

Rheological Properties of Sheared Vesicle and Cell Suspensions

Rheological Properties of Sheared Vesicle and Cell Suspensions

Prediction of Anomalous Blood Viscosity in Confined Shear Flow

Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift

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