Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates

Yang, Jing; Song, Zhichao; Shi, Liyi; Zhang, Qiang; Zhang, Cheng

doi:10.1021/acsami.6b04992

Cited by 33 publications

(16 citation statements)

References 33 publications

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“…A major challenge associated with TEM is the need for an “electron-transparent” substrate, through which electrons can pass freely without absorption or scattering, something not essential for either SEM or AFM. As an example of the power of this method, Yang et al [ 117 ] used TEM to image the positions of DNA origami tiles with AuNPs to determine the state of AND and OR logic gates.…”

Section: Characterizationmentioning

confidence: 99%

Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization

et al. 2021

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Bottom-up fabrication using DNA is a promising approach for the creation of nanoarchitectures. Accordingly, nanomaterials with specific electronic, photonic, or other functions are precisely and programmably positioned on DNA nanostructures from a disordered collection of smaller parts. These self-assembled structures offer significant potential in many domains such as sensing, drug delivery, and electronic device manufacturing. This review describes recent progress in organizing nanoscale morphologies of metals, semiconductors, and carbon nanotubes using DNA templates. We describe common substrates, DNA templates, seeding, plating, nanomaterial placement, and methods for structural and electrical characterization. Finally, our outlook for DNA-enabled bottom-up nanofabrication of materials is presented.

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Section: Characterizationmentioning

confidence: 99%

Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization

et al. 2021

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“…Nanoparticle assembly‐disassembly can be triggered by chemical signals processed through biomolecular logic gates representing a biocomputing nanoplatform for therapeutics and diagnostics . Biomolecular logic gates have been used to arrange dynamically gold nanoparticles on DNA origami . Assembling of gold nanoparticles has been demonstrated by using a pH‐responsive DNA nanomachine logically processing biomolecular input signals …”

Section: Macro/micro/nano‐mechanical Transduction Of Chemical Outputmentioning

confidence: 99%

“…[202] Biomolecular logic gates have been used to arrange dynamically gold nanoparticles on DNA origami. [203] Assembling of gold nanoparticles has been demonstrated by using ap H-responsive DNA nanomachine logically processingbiomolecular input signals. [204] Figure17A showst he biocatalytic cascade mimicking an OR logic gate.…”

Section: Atomicforce Microscopy (Afm) Transduction Of Chemical Outputmentioning

confidence: 99%

Enzyme‐Based Logic Gates and Networks with Output Signals Analyzed by Various Methods

Katz

2017

ChemPhysChem

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The paper overviews various methods that are used for the analysis of output signals generated by enzyme‐based logic systems. The considered methods include optical techniques (optical absorbance, fluorescence spectroscopy, surface plasmon resonance), electrochemical techniques (cyclic voltammetry, potentiometry, impedance spectroscopy, conductivity measurements, use of field effect transistor devices, pH measurements), and various mechanoelectronic methods (using atomic force microscope, quartz crystal microbalance). Although each of the methods is well known for various bioanalytical applications, their use in combination with the biomolecular logic systems is rather new and sometimes not trivial. Many of the discussed methods have been combined with the use of signal‐responsive materials to transduce and amplify biomolecular signals generated by the logic operations. Interfacing of biocomputing logic systems with electronics and “smart” signal‐responsive materials allows logic operations be extended to actuation functions; for example, stimulating molecular release and switchable features of bioelectronic devices, such as biofuel cells. The purpose of this review article is to emphasize the broad variability of the bioanalytical systems applied for signal transduction in biocomputing processes. All bioanalytical systems discussed in the article are exemplified with specific logic gates and multi‐gate networks realized with enzyme‐based biocatalytic cascades.

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“…Although these works revealed that NPs can be well assembled with DNA origami statically, the dynamic operation of an NP/DNA origami device is still a concern for various researchers. Our previous study realized a NP/DNA origami system, in which AuNPs could be dynamically released from a DNA origami in response to specific DNA signals [41]. In this work, the yield of the output structure was not very high, because a monofunctionalized DNA/AuNP conjugate was hybridized with one extended strand from the origami template.…”

Section: Introductionmentioning

confidence: 96%

Precise Control of Gold Nanoparticles on DNA Origami for Logic Operation

Chen

Yang

2019

Journal of Nanomaterials

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Owing to their capacity for accurate structural control and complex programmability, DNA molecules have been extensively studied in relation to the construction of nanodevices. However, the existing logic gate sections based on DNA self-assembly were independent of each other, which hampered the development of large-scale integrated DNA circuits. Herein, we have explored a logic operation device with excellent scalability based on assembling and selectively releasing AuNPs on DNA origami, and have performed YES gate, OR gate, AND gate, and three-input composite gate. In the experiment, the logic operation result is detected by gel analysis and TEM image. The resolution of the output signals was greatly improved by determining the releasing of AuNPs from two-layer honeycomb origami. Our study provides a promising approach for building more complex large-scale DNA logic circuits.

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Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates

Cited by 33 publications

References 33 publications

Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization

Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization

Enzyme‐Based Logic Gates and Networks with Output Signals Analyzed by Various Methods

Precise Control of Gold Nanoparticles on DNA Origami for Logic Operation

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