Dynamical states, possibilities and propagation of stress signal

Malik, Md. Zubbair; Ali, Shahnawaz; Ishrat, Romana

doi:10.1038/srep40596

Cited by 13 publications

(5 citation statements)

References 77 publications

(89 reference statements)

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“…p53 is well studied tumor supressor gene, playing important role in signal transduction as well as regulating stress inside the cell [ 50 , 51 ]. It is considered to be an important key candidate in cellular mechanisms, which is mainly responsible for cellular fate decision, either cell cycle arrest or apoptosis [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring novel key regulators in breast cancer network

et al. 2018

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The breast cancer network constructed from 70 experimentally verified genes is found to follow hierarchical scale free nature with heterogeneous modular organization and diverge leading hubs. The topological parameters (degree distributions, clustering co-efficient, connectivity and centralities) of this network obey fractal rules indicating absence of centrality lethality rule, and efficient communication among the components. From the network theoretical approach, we identified few key regulators out of large number of leading hubs, which are deeply rooted from top to down of the network, serve as backbone of the network, and possible target genes. However, p53, which is one of these key regulators, is found to be in low rank and keep itself at low profile but directly cross-talks with important genes BRCA2 and BRCA3. The popularity of these hubs gets changed in unpredictable way at various levels of organization thus showing disassortive nature. The local community paradigm approach in this network shows strong correlation of nodes in majority of modules/sub-modules (fast communication among nodes) and weak correlation of nodes only in few modules/sub-modules (slow communication among nodes) at various levels of network organization.

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Section: Resultsmentioning

confidence: 99%

Exploring novel key regulators in breast cancer network

et al. 2018

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“…The topological properties of ovarian cancer PPI network are characterized by degree distribution, clustering co-efficient, connectivity and centrality (betweenness, closeness and eigen-vector) measurements (for details see Additional file 1). We use these parameters to understand topological changes when the network is perturbed [14, 18, 19].…”

Section: Methodsmentioning

confidence: 99%

Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

et al. 2019

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BackgroundIdentification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the key regulators of this network and their importance.MethodsThe protein-protein interaction (PPI) network of ovarian cancer (OC) is constructed from curated 6 hundred genes from standard six important ovarian cancer databases (some of the genes are experimentally verified). We proposed a method to identify key regulators (KRs) from the complex ovarian cancer network based on the tracing of backbone hubs, which participate at all levels of organization, characterized by Newmann-Grivan community finding method. Knockout experiment, constant Potts model and survival analysis are done to characterize the importance of the key regulators in regulating the network.ResultsThe PPI network of ovarian cancer is found to obey hierarchical scale free features organized by topology of heterogeneous modules coordinated by diverse leading hubs. The network and modular structures are devised by fractal rules with the absence of centrality-lethality rule, to enhance the efficiency of signal processing in the network and constituting loosely connected modules. Within the framework of network theory, we device a method to identify few key regulators (KRs) from a huge number of leading hubs, that are deeply rooted in the network, serve as backbones of it and key regulators from grassroots level to complete network structure. Using this method we could able to identify five key regulators, namely, AKT1, KRAS, EPCAM, CD44 and MCAM, out of which AKT1 plays central role in two ways, first it serves as main regulator of ovarian cancer network and second serves as key cross-talk agent of other key regulators, but exhibits disassortive property. The regulating capability of AKT1 is found to be highest and that of MCAM is lowest.ConclusionsThe popularities of these key hubs change in an unpredictable way at different levels of organization and absence of these hubs cause massive amount of wiring energy/rewiring energy that propagate over all the network. The network compactness is found to increase as one goes from top level to bottom level of the network organization.

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“…This implies that kaempferol may be more beneficial as a preventive agent [102]. Kaempferol has been shown in several studies to protect the liver against a variety of oxidative stressors [103][104][105]. Furthermore, data demonstrated that kaempferol had no substantial toxicity on normal cells.…”

Section: Liver Cancermentioning

confidence: 99%

The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers: Recent Trends and Future Perspectives

Singh,

Sharma,

Sharma

et al. 2024

Cancers

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In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment.

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Dynamical states, possibilities and propagation of stress signal

Cited by 13 publications

References 77 publications

Exploring novel key regulators in breast cancer network

Exploring novel key regulators in breast cancer network

Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers: Recent Trends and Future Perspectives

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