Dynamical modeling approach to risk assessment for radiogenic leukemia among astronauts engaged in interplanetary space missions

Smirnova, Olga A.; Cucinotta, Francis A.

doi:10.1016/j.lssr.2017.12.002

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Computational and mathematical modeling associated with cancer radiotherapy and radiation risk assessments have been undertaken for decades, and they proceed along with the new biophysics phenomena that have been identified [ 14 , 15 , 16 , 17 , 18 ]. Along with the modeling of radiation risk itself, there are a series of models designed to understand the kinetics of radiation-induced DNA damage repair and associated secondary cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Belov,

Chigasova,

Pustovalova

et al. 2023

CIMB

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Understanding the relative contributions of different repair pathways to radiation-induced DNA damage responses remains a challenging issue in terms of studying the radiation injury endpoints. The comparative manifestation of homologous recombination (HR) after irradiation with different doses greatly determines the overall effectiveness of recovery in a dividing cell after irradiation, since HR is an error-free mechanism intended to perform the repair of DNA double-strand breaks (DSB) during S/G2 phases of the cell cycle. In this article, we present experimentally observed evidence of dose-dependent shifts in the relative contributions of HR in human fibroblasts after X-ray exposure at doses in the range 20–1000 mGy, which is also supported by quantitative modeling of DNA DSB repair. Our findings indicate that the increase in the radiation dose leads to a dose-dependent decrease in the relative contribution of HR in the entire repair process.

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Section: Introductionmentioning

confidence: 99%

Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Belov,

Chigasova,

Pustovalova

et al. 2023

CIMB

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“…The effect of IR on amino acid chemistry is highly relevant to fields ranging from cancer radiotherapy to space travel to national defense (25)(26)(27)(28)(29). The first step in detailing these chemistries is to bridge the gaps in our understanding of the differences between IR effects on free amino acids and amino acids participating in peptide bonds.…”

mentioning

confidence: 99%

Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy

Minkoff¹,

Bruckbauer

Sabat³

et al. 2019

Radiation Research

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To identify modifications to amino acids directly induced by ionizing radiation (IR), free amino acids and 3-residue peptides were exposed to radiation generated by a linear accelerator (Linac) used in radiotherapy. Mass spectrometry was performed to detail the relative sensitivity to radiation as well as identify covalent, IR-dependent adducts. The order of reactivity of the 20 common amino acids was generally in agreement with published literature except for His (most reactive of the 20) and Cys (less reactive). Novel and previously identified modifications on the free amino acids were detected. Amino acids were far less reactive when flanked by glycine residues in a tripeptide. Order of reactivity, with GVG most and GEG least, was substantially altered, as were patterns of modification. IR reactivity of amino acids is clearly and strongly affected by conversion of the α-amino and α-carboxyl groups to peptide bonds, and the presence of neighboring amino acid residues.

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Radiation Risk Assessment

Hellweg

Matthiä

Berger

et al. 2020

Radiation in Space: Relevance and Risk for Human Missions

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Dynamical modeling approach to risk assessment for radiogenic leukemia among astronauts engaged in interplanetary space missions

Cited by 4 publications

References 22 publications

Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation

Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy

Radiation Risk Assessment

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