Dynamic View on Affordability of Fixed-Dose Combination Antihypertensive Drug Therapy

Abstract

The cost advantage of FDCs over FCs was reversed when FCs were generically available. The finding of this study informs patients, health-care providers, and drug plans of the importance of making dynamic decisions on preferred drug therapy options depending on the availability of generic drugs.

Fixed‐dose vs free‐dose combinations for the management of hypertension—An analysis of 81 958 patients

“…As expected, fixed‐dose combinations of both R/A and C/A were more expensive per patient year than their free‐dose counterparts. This is largely owing to the wide availability of generic single‐component drugs in Germany, which can be more cheaply prescribed as multi‐pill regimens . However, this is an extremely minimalist view of expenditures in hypertensive patients, which additionally include the cost of other medications, outpatient care, emergency department visits, and hospital admissions .…”

“…This is largely owing to the wide availability of generic singlecomponent drugs in Germany, which can be more cheaply prescribed as multi-pill regimens. 29 However, this is an extremely minimalist view of expenditures in hypertensive patients, which additionally include the cost of other medications, outpatient care, emergency department visits, and hospital admissions. 30 Indeed, the increased adherence associated with FDCs has been shown to translate into reduced health care use, which in turn results in cost savings that offset initial drug expenditure.…”

Synthesis of α,α-difluoro-β-amino carbonyl-containing sulfonamides and related compounds

“…3 Hz,1F). IR (KBr): n = 3252, 2923,1707,1447,1332,1167,1082,1064,810,753,723,659,587,560 3,142.4,137.9,134.7,132.1,130.1,129.6,129.1,129.0,126.3,124.2,116.7 (dd,J = 261.5,256.1 Hz),113.5,59.2 (dd,J = 28.4,22.3 Hz), 55.1,20.8;19 F NMR (376 MHz,d 6 -DMSO) d À103.1 (d,J = 257.5 Hz,1F), À110.8 (d,J = 257.5 Hz,1F). IR (KBr): n = 3238, 1703,1515,1335,1256,1165,1086,1063,756,724,677,659,585,541 3, 137.4, 134.8, 132.9, 132.4, 131.0, 129.5, 129.0, 128.7, 127.2, 126.9, 126.0, 125.7, 125.0, 122.0, 117. 142.5, 137.6, 134.8, 132.5, 132.2, 132.0, 129.6, 129.1, 128.8, 127.8, 127.7, 127.4, 126.5,...…”

“…Throughout the years, several successful sulfonamide-based drugs have been introduced to the pharmaceutical market [1]. To mention just a few, Viagra [2], Diovan HCT [3] and fluorine-containing Crestor and Celebrex [4] are currently among the most widely used drugs. Following the advances in organic chemistry, new and structurally more complex types of sulfonamides are currently being synthesized and biologically evaluated.…”

Fixed-Dose Combination Drug Approvals, Patents and Market Exclusivities Compared to Single Active Ingredient Pharmaceuticals

“…FDC drugs allow pharmaceutical companies to maintain market share as the single active ingredient drugs lose patent protection and generic drugs enter the market increasing competition, and driving prices down [ 27 , 33 , 34 ]. Shifting the demand to FDC drugs as patents and exclusivities of single active ingredients expire may impose a financial burden on public and private health programs and patients [ 27 , 35 – 37 ]. Research is needed to assess the cost-effectiveness of FDC compared to single active ingredient pharmaceuticals.…”