Fixed‐dose vs free‐dose combinations for the management of hypertension—An analysis of 81 958 patients

Bramlage, Peter; Schmidt, Stefanie; Sims, Helen

doi:10.1111/jch.13240

Cited by 33 publications

(44 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Disease CVD (n = 11) [35,45,48,49,52,[58][59][60][61][62][63] HT (n = 31) [5,33,[38][39][40][41][42]46,53,55,56,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83]] DMII (n = 10) [31,32,36,43,44,51,54,[84][85][86]] HIV (n = 14) [30,…”

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

et al. 2020

View full text Add to dashboard Cite

Many patients, especially those with a high pill burden and multiple chronic illnesses, are less adherent to medication. In medication treatments utilizing polypills, this problem might be diminished since multiple drugs are fused into one formulation and, therefore, the therapy regimen is simplified. This systematic review summarized evidence to assess the effect of polypills on medication adherence. The following databases were searched for articles published between 1 January 2000, and 14 May 2019: PubMed, Web of Science, Cochrane Library, and Scopus. Medication adherence was the only outcome assessed, regardless of the method of measuring it. Sixty-seven original peer-reviewed articles were selected. Adherence to polypill regimens was significantly higher in 56 articles (84%) compared to multiple pill regimens. This finding was also supported by the results of 13 out of 17 selected previously published systematic reviews and meta-analyses dealing with this topic. Adherence can be improved through the formulation of polypills, which is probably why the interest in researching them is growing. There are many polypills on the market, but the adherence studies so far focused mainly on a small range of medical conditions.

show abstract

Section: Results (Number Of Studies With a Certain Feature) Referencesmentioning

confidence: 99%

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Already, guidelines on the management of CVD recommend combining drugs from different pharmacological classes to prevent morbidity associated with CVD [27] and the diabetic patient often requires an additional drug to achieve glycaemic control [28]. The fixed-dose combination is recommended to reduce pill burden but usually comes at a higher cost than two separate products [29]. In Nigeria, health insurance is not yet common, so the benefit of the pill burden reduction is usually weighed carefully against the cost.…”

Section: Discussionmentioning

confidence: 99%

Prescription Pattern of Cardiovascular and/or Antidiabetic Drugs in Abuja District Hospitals

Osuafor¹,

Ukwe²,

Okonta³

2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective:The study aimed to describe the prescription pattern of cardiovascular and/or anti-diabetic drugs and adherence to the World Health Organization (WHO) prescribing indicators in Abuja District Hospitals.Methods: This descriptive retrospective study was carried out in Asokoro and Maitama District Hospitals Abuja. One thousand and nine prescriptions that contained a cardiovascular drug (CVD) and/or anti-diabetic drug issued between June 2017 and May 2018 from the Medical Outpatient Department were analyzed. Data were collected from the pharmacy electronic database, prescription pattern and adherence to WHO prescribing indicators were assessed. The analysis was done using descriptive statistics. Results were presented as percentages, means, and standard deviations. Results:The frequency of treatment was higher among women (58.8%) and the age group of 41-60 (54.8%). The average number of drugs prescribed was 3.3±1.6: the percentage of drugs prescribed in generic was (64%) and (78.8%) were from the Essential Drug List (EDL). Calcium Channel Blockers (CCB, 71.7%) and Biguanides (B, 92.4%) were the most prescribed CVD and anti-diabetic drug. The majority of the CVD (74.5%) and diabetes (63.6%) patients were on combination therapy. The most frequent CVD combination was CCB plus Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers (29.7%). Compared to men, the proportion of females taking one or more CVD (61.3%) or antidiabetic (56.4%) was higher. Conclusion:The prescribing indicators are not optimal in Abuja district hospitals. Women received more treatment for cardiovascular and diabetes diseases than men while the age range of 41-60 was more treated than other age groups.

show abstract

“…Выделяют следующие недостатки КАГППД [29,30]: 1) патентованные комбинированные препараты могут быть более дорогостоящими по сравнению с эквивалентными СКАГП; 2) продолжительность действия отдельных компонентов может быть неэквивалентна, что может обусловливать неприемлемость применения 1 раз в сутки (р/сут); 3) применение КАГППД ограничивает возможность гибкого подхода к дозированию препарата, и на определенных этапе обусловливает чрезмерную интенсивность антигипертензивной терапии.…”

Section: комбинированная антигипертензивная терапия как необходимое уunclassified

“…Следует отметить, что результаты крупного обсервационного исследования, включавшего 81958 больных с АГ, свидетельствовали о том, что КАГППД чаще применяли у больных с менее тяжелыми ССЗ [30]. В частности, у больных с коронарной болезнью сердца частота сочетанного применения кандесартана и амлодипина в виде КАГППД и в виде СКАГП достигала 14,4 и 25,2%, соответственно (p<0,001), а у больных с инсультом в анамнезе такая частота составляла 5,6 и 10% (p<0,001), соответственно.…”

Section: комбинированная антигипертензивная терапия как необходимое уunclassified

A Flexible Regimen of Combination Antihypertensive Therapy for Lower Blood Pressure to the Lower Target Level. Viewpoint of Cardiologist and Clinical Pharmacologist

Gilyarevskiy

Голшмид

Zaharova

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

1 Российская медицинская академия непрерывного профессионального образования Россия, 125993, Москва, ул. Баррикадная, 2/1 2 Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Россия, 129090, Москва, Большая Сухаревская пл., 3 В статье рассматриваются современные подходы к выбору тактики антигипертензивной терапии с использованием комбинированных антигипертензивных препаратов с постоянными дозами или с использованием свободных комбинаций антигипертензивных препаратов. Приводятся данные о том, что в современных условиях лечения артериальной гипертонии использование гибкого подхода к выбору тактики применения комбинированных антигипертензивных препаратов представляется более обоснованным. В частности, с учетом результатов анализа данных об участниках рандомизированного клинического исследования SPRINT обсуждается вопрос о характеристиках больных с артериальной гипертонией, у которых для улучшения прогноза может быть полезно снижение артериального давления (АД) до более низких целевых уровней. Обсуждаются подходы к уменьшению частоты развития нежелательных явлений, обусловленных антигипертензивной терапией, у таких больных в целом, и у больных пожилого и старческого возраста, имеющих не только высокую вероятность достижения преимуществ более интенсивных режимов антигипертензивной терапии по влиянию на прогноз, но и более высокий риск осложнений, обусловленных терапией. Обсуждается проблема менее высокой эффективности применения воспроизведенных антигипертензивных препаратов («дженериков») по сравнению с оригинальными препаратами. Ключевые слова: антигипертензивная терапия, комбинированные антигипертензивные препараты, амлодипин. Для цитирования: Гиляревский С.Р., Голшмид М.В., Захарова Г.Ю., Кузьмина И.М., Синицина И.И. Гибкий режим применения комбинированной антигипертензивной терапии в условиях снижения артериального давления до более низких целевых уровней: взгляд кардиолога и клинического фармаколога. Рациональная Фармакотерапия в Кардиологии 2019;15(2):265-270.Modern tactics of antihypertensive therapy with fixed dose combination or with free combinations of antihypertensive drugs are reviewed in the article. The evidence that a flexible regimen of combination antihypertensive therapy is more reasonable in the modern treatment of arterial hypertension is presented. The question of the characteristics of hypertensive patients in whom lowering blood pressure to lower target levels may be useful to improve the prognosis is discussed considering the results of the analysis of data on participants in a randomized clinical trial SPRINT. Approaches to reducing the incidence of adverse events caused by antihypertensive therapy in such patients in general and in elderly and senile patients who have not only a higher likelihood of achieving advantages of more intensive antihypertensive therapy regimens for influencing the prognosis, but also a higher risk of complications, due to therapy are considered. The problem of less high efficacy of using replicated antihypertensive drugs (generics) compared to...

show abstract

Fixed‐dose vs free‐dose combinations for the management of hypertension—An analysis of 81 958 patients

Cited by 33 publications

References 30 publications

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

Prescription Pattern of Cardiovascular and/or Antidiabetic Drugs in Abuja District Hospitals

A Flexible Regimen of Combination Antihypertensive Therapy for Lower Blood Pressure to the Lower Target Level. Viewpoint of Cardiologist and Clinical Pharmacologist

Contact Info

Product

Resources

About