Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic  hepatitis and liver cirrhosis

Dertli, Ramazan; Keskın, Muharrem; Bıyık, Murat; Ataseven, Hüseyin; Polat, Hakkı; Demir, Ali; Oltulu, Pembe; Neşeloğlu, Salim; Erel, Özcan; Asıl, Mehmet

doi:10.3906/sag-1803-135

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…This increased oxidative stress in CHC may be caused by chronic inflammation and continuous production of ROS in HCV‐infected cells 16 . Similarly, researchers have observed that the DTDH shifted to the DS side in other infectious diseases such as chronic hepatitis B 9 and Crimean‐Congo haemorrhagic fever 10 …”

Section: Discussionmentioning

confidence: 96%

“…Previous studies have reported that impaired DTDH plays a role in the pathogenesis of various diseases such as chronic hepatitis B, 9 Crimean‐Congo haemorrhagic fever, 10 diabetes 11 and familial Mediterranean fever 12 . However, DTDH, an alternative indicator of oxidative stress, has not yet been investigated using the new method in HCV‐infected patients.…”

Section: Introductionmentioning

confidence: 99%

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Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

Çakırca

Ceylan

Koyuncu

et al. 2021

Int. J. Clin. Pract.

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Chronic hepatitis C (CHC) infection is a liver disease caused by the hepatitis C virus (HCV). It is a major public health problem, affecting approximately 71 million people worldwide, and is one of the leading causes of cirrhosis, hepatocellular cancer and liver-related deaths. It is estimated that approximately 400 000 people died in 2015 from complications related to CHC. 1 Although the mechanism of how HCV induces liver damage is not fully understood to date, it has been suggested that oxidative stress plays a pivotal role in the pathogenesis of CHC. [2][3][4] Oxidative stress, caused by the deterioration of homeostasis between reactive oxygen species (ROS) and antioxidants, triggers liver damage by inducing DNA damage, lipid peroxidation and protein oxidation in the organism. The increased oxidative stress in HCV infection induces hepatic stellate cell activation, DNA damage and gene mutation, which progresses towards liver fibrosis/cirrhosis and hepatocellular carcinoma. 5 Thiols containing the sulfhydryl (SH) group are part of the antioxidant defence system as they are metal chelators, free radical scavengers and thiol/disulphide redox buffer components. The thiol groups of sulphur-containing compounds, the main targets of ROS, react with oxidant molecules to form disulphide bonds (S-S). This process

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

Çakırca

Ceylan

Koyuncu

et al. 2021

Int. J. Clin. Pract.

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“…It has been shown that increased OS may have a role in the pathogenesis of idiopathic recurrent AP. Many recent studies have reported on thiol levels and thiol/SS homeostasis in patients with chronic hepatitis, ulcerative colitis, and coronary artery disease (14)(15)(16)(17); however, till date, only one study has been conducted on patients with AP (18). To the best of our knowledge, no studies have been conducted with regard to IMA.…”

Section: Introductionmentioning

confidence: 99%

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

Uyanıkoğlu

Sabuncu

Yıldız

et al. 2020

Turk J Gastroenterol

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Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP). Materials and Methods: A total of 28 patients with AP (AP group) and 35 age-and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups. Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups. Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

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“…7 While the thiol side of the thiol-disulfide system has been measured since 1979, it was only in 2014 that Erel and Neselioglu developed a reliable way to measure the level of both components of this system quickly and cheaply. 8 Previous studies have reported that impaired DTDH plays a role in the pathogenesis of various diseases such as chronic hepatitis B, 9 Crimean-Congo hemorrhagic fever, 10 diabetes 11 and familial Mediterranean fever. 12 However, DTDH, an alternative indicator of oxidative stress, has not yet been investigated using the new method in HCV-infected patients.…”

Section: Introductionmentioning

confidence: 99%

Thiol-disulfide balance and total oxidant-antioxidant status in patients with chronic hepatitis C

Çakırca¹,

Ceylan²,

Koyuncu³

et al. 2020

Preprint

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Objective: Increasing evidences suggest that oxidative stress is closely related to the pathogenesis of hepatitis C virus (HCV) infection. The purpose of this study was to examine the dynamic thiol/disulfide homeostasis (DTDH) and total oxidant/antioxidant status in patients with HCV infection. Methods: Levels of serum total thiol (TT), native thiol (NT), disulfide (DS), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI; TOS/TAS ratio) as oxidative stress markers were determined in 162 individuals, including 74 patients with HCV infection and 88 non-HCV controls. Results: The NT, TT levels and NT/TT ratio were significantly lower and DS level, DS/NT and DS/TT ratios were significantly higher in HCV group compared to the control group. The TOS and OSI values were significantly higher and the TAS level was significantly lower in the HCV group than in the control group. No significant correlations were found between oxidative stress markers and albumin, alanine aminotransferase, aspartate aminotransferase and bilirubin levels in patients with HCV infection. A negative correlation was found only between OSI and albumin. Conclusion: These results indicate that patients with HCV infection are vulnerable to oxidative stress and have disturbed status of oxidant and antioxidant. What's knownOxidative stress is associated with pathogenesis of hepatitis C virus (HCV) infection.Thiols are oxidized by oxidant radicals and form disulfide bonds. Dynamic thiol-disulfide homeostasis is an important indicator used to evaluate the presence and intensity of oxidative stress.Abnormal dynamic thiol-disulfide homeostasis plays a role in the pathogenesis of various diseases. What's newThis study is the first report of thiol-disulfide homeostasis in HCV-infected patients.Thiol/disulfide homeostasis is disturbed and shifts to the disulfide side in patients with HCV infection. TOS and OSI were higher and TAS was lower in HCV-infected patients compared to healthy controls.This study shows that patients with HCV infection are vulnerable to oxidative stress and have disturbed status of oxidant-antioxidant.

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Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis

Cited by 10 publications

References 26 publications

Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

Thiol‐disulphide balance and total oxidant‐antioxidant status in patients with chronic hepatitis C

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

Thiol-disulfide balance and total oxidant-antioxidant status in patients with chronic hepatitis C

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