Dynamic <sup>11</sup>C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis

Schubert, Julia; Veronese, Mattia; Marchitelli, Livia; Bodini, Benedetta; Tonietto, Mattéo; Stankoff, Bruno; Brooks, David J.; Bertoldo, Alessandra; Edison, Paul; Turkheimer, Federico

doi:10.2967/jnumed.118.223834

Cited by 70 publications

(44 citation statements)

References 59 publications

(70 reference statements)

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“…Leptomeningeal inflammation is frequently observed in MS and other neuroinflammatory conditions (44,45). Impairment of CSF elimination associated with meningeal inflammation could contribute to transient VV changes in MS. Support for this notion comes from a recent study using the positron-emission tomography tracer 11 C-PiB, which showed reduced CSF clearance in MS patients compared with healthy controls (46).…”

Section: Discussionmentioning

confidence: 99%

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

et al. 2020

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“…The 11C-PiB signal in the lateral ventricles was measured for compartmental modeling, and significant group differences were observed across AD, mild cognitive impairment (MCI), and healthy controls. This result indicated the association of CSF clearance deficits in AD with Aβ deposits [ 47 ]. Another study utilized diffusion imaging to detect ISF dynamics in AD.…”

Section: Disorders Categorized In Cns Interstitial Fluidopathiesmentioning

confidence: 93%

“…In the study of amyloid imaging using PiB PET to detect CSF clearance alterations, clearance in lateral ventricular was significantly lower in patients with multiple sclerosis than that in the healthy controls. The results indicate that there are pathologic changes in ISF and CSF dynamics [ 47 ]. Several other disorders which might be related to CSF or ISF dynamics and have not been discussed as a point of interstitial fluidopathy including CSF hypovolemia, leukoaraiosis or periventricular leukomalacia in infants, and investigations are expected for these disorders.…”

Section: Disorders Categorized In Cns Interstitial Fluidopathiesmentioning

confidence: 99%

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Taoka

Naganawa

2020

Jpn J Radiol

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After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer’s disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose “Central Nervous System (CNS) Interstitial Fluidopathy” as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as “CNS interstitial fluidopathies,” will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for “CNS interstitial fluidopathies.”

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“…Studies have demonstrated a close relationship between the glymphatic system and AD. AD patients show altered CSF dynamics, thereby inducing impairments in CSF-dependent Aβ clearance and consequent pathological Aβ accumulation [ 414 ]. Moreover, inhibition of glymphatic transport leads to a significant accumulation of Aβ in APP/PS1 mouse brain [ 415 ].…”

Section: Glial Contributions To Ad Pathogenesismentioning

confidence: 99%

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo

Zhang

Zeng

et al. 2020

Mol Neurodegeneration

484

294

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Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism. Studies within the last few decades provide growing evidence for a central role of amyloid β (Aβ) and tau, as well as glial contributions to various molecular and cellular pathways in AD pathogenesis. Herein, we review recent progress with respect to Aβ-and tau-associated mechanisms, and discuss glial dysfunction in AD with emphasis on neuronal and glial receptors that mediate Aβ-induced toxicity. We also discuss other critical factors that may affect AD pathogenesis, including genetics, aging, variables related to environment, lifestyle habits, and describe the potential role of apolipoprotein E (APOE), viral and bacterial infection, sleep, and microbiota. Although we have gained much towards understanding various aspects underlying this devastating neurodegenerative disorder, greater commitment towards research in molecular mechanism, diagnostics and treatment will be needed in future AD research.

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Dynamic ¹¹C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis

Cited by 70 publications

References 59 publications

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

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Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis

Cited by 70 publications

References 59 publications

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis

Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

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Dynamic ¹¹C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis