Dynamic perioperative variation of neutrophil-to-lymphocyte ratio as an independent prognosis factor following lobectomy for NSCLC

Raíces, Micaela; Lucas, C.F.; Corvatta, Franco Alejandro; Cayol, Federico; Dietrich, Alexander; David, Smith

doi:10.1007/s13304-020-00936-x

Cited by 6 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From this perspective, the serial monitoring of markers of systemic inflammation pre- and postoperatively may provide more information regarding outcomes than preoperative monitoring, but this issue requires further in-depth analysis. 47…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the preoperative neutrophil-to-lymphocyte ratio as a predictor of the micropapillary component of stage IA lung adenocarcinoma

Chen,

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

Objective To assess the ability of markers of inflammation to identify the solid or micropapillary components of stage IA lung adenocarcinoma and their effects on prognosis. Methods We performed a retrospective study of clinicopathologic data from 654 patients with stage IA lung adenocarcinoma collected between 2013 and 2019. Logistic regression analysis was used to identify independent predictors of these components, and we also evaluated the relationship between markers of inflammation and recurrence. Results Micropapillary-positive participants had high preoperative neutrophil-to-lymphocyte ratios. There were no significant differences in the levels of markers of systemic inflammation between the participants with or without a solid component. Multivariate analysis showed that preoperative neutrophil-to-lymphocyte ratio (odds ratio [OR] = 2.094; 95% confidence interval [CI], 1.668–2.628), tumor size (OR = 1.386; 95% CI, 1.044–1.842), and carcinoembryonic antigen concentration (OR = 1.067; 95% CI, 1.017–1.119) were independent predictors of a micropapillary component. There were no significant correlations between markers of systemic inflammation and the recurrence of stage IA lung adenocarcinoma. Conclusions Preoperative neutrophil-to-lymphocyte ratio independently predicts a micropapillary component of stage IA lung adenocarcinoma. Therefore, the potential use of preoperative neutrophil-to-lymphocyte ratio in the optimization of surgical strategies for the treatment of stage IA lung adenocarcinoma should be further studied.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the preoperative neutrophil-to-lymphocyte ratio as a predictor of the micropapillary component of stage IA lung adenocarcinoma

Chen,

et al. 2024

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Previous studies have consistently demonstrated that a high baseline NLR was associated with adverse survival outcomes in many solid tumors. [5][6][7][8][9][10][11]27 However, NLR appears as a dynamic measure of immunity, and some studies have suggested that decreasing NLR correlated with favourable outcomes in the setting of surgery for lung 28 or gastric 29 cancers, chemotherapy for colorectal cancer, 30 and immunotherapy for advanced solid tumors. 31 For HCC, post-treatment NLR change was proposed to have superior discriminatory power for survival outcomes compared to baseline NLR in patients receiving RFA 32 or sorafenib.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma

Hsiang¹,

Huang²,

Yang³

et al. 2021

JHC

View full text Add to dashboard Cite

“…NLR-delta has been demonstrated as an alternative prognostic factor in patients with non-small cell lung cancer, hepatocellular carcinoma, gastric cancer, and anaplastic thyroid cancer. [11][12][13][14][15][16] However, there are still some discrepancies in the clinical significance of grouping the NLR-pre and NLP-post 9,10 and the clinical significance of NLR-delta in patients with CRC also showed conflicting results. 17,18 In addition, the significance of combining pre-and post-operative NLR (NLR-trend) and NLR-delta has rarely been evaluated simultaneously, and it remains unclear whether there is a difference in the strength of association with survival between the two dynamic matrices.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer

Kim

Lee

et al. 2021

JIR

View full text Add to dashboard Cite

Background: Recent data suggest that alterations in the neutrophil-to-lymphocyte ratio (NLR) in the perioperative periods can serve as prognostic factors. However, research on the clinical impact has been limited and even discordant in patients with colorectal cancer (CRC). Patients and Methods: The optimal cut-off value of preoperative NLR (NLR-pre), postoperative NLR (NLR-post), and its change (NLR-delta) were determined to maximize differences in overall survival (OS) between groups. Patients were categorized into four groups (NLR-trend) as follows: G1, low NLR-pre and NLR-post; G2, low NLR-pre and high NLR-post; G3, high NLR-pre and low NLR-post; and G4, high NLR-pre and NLR-post. Discriminatory performance was compared using integrated AUC (iAUC) between all indicators. Results: A total of 576 patients diagnosed with stage I-IV CRC were included. The cut-off points were determined as 2.33 for NLR-pre, 2.06 for NLR-post, and −1.08 for NLR-delta. Subgroup dichotomization using NLR-pre, NLR-post, NLR-delta and NLR-trend were all identified as significant prognostic factors by univariate analysis. However, NLR-trend was only remained as an independent prognostic factor in the multivariate analysis. The iAUC of the NLR-trend was superior to that of NLR-pre (bootstrap iAUC mean difference=0.036; 95% CI 0.013-0.073), NLR-post (bootstrap iAUC mean difference=0.045; 95% CI 0.019-0.081) and NLR-delta (bootstrap iAUC mean difference=0.061; 95% CI 0.025-0.104). Conclusion: Risk stratification and combining of preoperative and postoperative NLR (NLR-trend) can improve prognostic discrimination compared with single measurements or simple changes in NLR in patients with CRC.

show abstract

Dynamic perioperative variation of neutrophil-to-lymphocyte ratio as an independent prognosis factor following lobectomy for NSCLC

Cited by 6 publications

References 19 publications

Evaluation of the preoperative neutrophil-to-lymphocyte ratio as a predictor of the micropapillary component of stage IA lung adenocarcinoma

Evaluation of the preoperative neutrophil-to-lymphocyte ratio as a predictor of the micropapillary component of stage IA lung adenocarcinoma

Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma

Elevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer

Contact Info

Product

Resources

About