2021
DOI: 10.2147/jhc.s334933
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Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma

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Cited by 10 publications
(11 citation statements)
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“…Of note, markers correlating with overall survival might be specific to cancer histology, as we have previously reported for HCC versus CCA patients [47]. Three studies also reported inverse correlations between the baseline neutrophil-to-lymphocyte ratio (NLR) and treatment outcome (Byun et al: HR 1.03 (95%CI 1.01-1.06); p= 0.016) [48,50,53]. Hsiang and colleagues additionally reported an association between liver toxicity and the maximal change in NLR [liver toxicity rate (delta NLR< vs. >1.9): 7.5% vs. 35.1%].…”
Section: Circulating Blood Cellsmentioning
confidence: 68%
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“…Of note, markers correlating with overall survival might be specific to cancer histology, as we have previously reported for HCC versus CCA patients [47]. Three studies also reported inverse correlations between the baseline neutrophil-to-lymphocyte ratio (NLR) and treatment outcome (Byun et al: HR 1.03 (95%CI 1.01-1.06); p= 0.016) [48,50,53]. Hsiang and colleagues additionally reported an association between liver toxicity and the maximal change in NLR [liver toxicity rate (delta NLR< vs. >1.9): 7.5% vs. 35.1%].…”
Section: Circulating Blood Cellsmentioning
confidence: 68%
“…Potential Predictive Scores/Biomarkers ALBI [23][24][25][26][27]29] ALBI [23][24][25]29,39] Absolute lymphocyte count [43] Indocyanin Green Retention [35][36][37] Hepatocyte growth factor (HGF) [40,41] HGF [40,41] CD40 Ligand (CD40L) [45] sCD40L [40,45] Platelet-to-lymphocyte ratio [43] Transforming growth factor (TGF)-β [42] Neutrophile-to-Lymphocyte ratio [43,50,53] Neutrophile-to-Lymphocyte ratio [53] Interleukin 6 (IL-6) [43,44] Eotaxin [42] Interleukin 10 (IL-10) [44] TNF receptor I (TNFR-I) [46] Tumor Necrosis Factor receptor II [45] TNFR-II [45] Circulating lymphocyte counts [47,[49][50][51][52] Circulating lymphocyte counts [49] Tumor Necrosis Factor (TNF)-α [51] Micro RNAs [101] Cell-free DNA [90] Plasma metabolites [98] Ceramide [99] Programmed cell d...…”
Section: Potential Prognostic Scores/biomarkersmentioning
confidence: 99%
“… 11–14 The NLR cut-off was 1.9 according to a previous study. 15 Abdominal ultrasonography (US) and contrast-enhanced CT/MRI were used to evaluate cirrhosis, tumour diameter, number of tumours and presence of portal vein (PV) invasion. All patients were followed up by abdominal examination (US/CT/MRI) and assessments of AFP levels after the operation at intervals of 3–6 months.…”
Section: Methodsmentioning
confidence: 99%
“…The higher levels of NLR were consistently associated with decreased survival with ICIs, possibly due to increased inflammatory pressure leading to immune exhaustion; however, the cutoffs for NLR and patient cohorts were very variable [ 21 , 22 , 23 , 24 , 25 ]. Additionally, the dynamic changes in NLR could reflect the changes in the immune machinery in response to ICIs and could present a minimally invasive way to monitor the host earlier in the treatment course [ 26 , 27 , 28 ]. Considering the instrumental role of adaptive immune system as a driver of ICI efficacy, the exploitation of NLR as a prognostic biomarker has a strong biologic rationale [ 29 ].…”
Section: Introductionmentioning
confidence: 99%