Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol—comparison with MAG3 scintigraphy

Boss, Andreas; Martirosian, Petros; Fuchs, Jörg; Obermayer, F; Tsiflikas, Ilias; Schick, Fritz; Schäfer, Jürgen

doi:10.1259/bjr.20140426

Cited by 19 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparative studies on volumetric SRF evaluation by DRS and functional MR urography have shown a good correlation between the two techniques, where functional MR urography offers the advantage of calculating the volume of enhanced renal parenchyma (16)(17)(18)(19)(20)(21). Although these provide evidence for a comprehensive multicenter comparative study on different CAKUT phenotypes which calculate the volumetric SRF using the Area Under the Curve, the Rutland-Patlak method and the volume proportion expressed as a percentage together with the comparative evaluation of drainage curves is lacking.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Damasio

Bodria

Dolores³

et al. 2020

Front. Pediatr.

View full text Add to dashboard Cite

Background: Obstructive congenital anomalies of the kidney and urinary tract have a high risk of kidney failure if not surgically corrected. Dynamic renal scintigraphy is the gold standard technique to evaluate drainage curves and split renal function (SRF).Objectives: To compare functional magnetic resonance (MR) urography with dynamic renal scintigraphy in measuring volumetric SRF and in the classification of drainage curves in patients with congenital anomalies of the kidney and urinary tract. Materials and Methods:We retrospectively collected patients with hydroureteronephrosis or pelvicalyceal dilatation at renal ultrasound, who underwent both functional MR urography and dynamic renal scintigraphy (DRS) within 6 months. DRS studies were evaluated by a single nuclear medicine physician with a double reading. Functional MR urography renograms were blind evaluated twice by two radiologists. The functional MR urographyintra-and inter-reading agreements as well as the agreement between the two imaging techniques were calculated. SRF was evaluated by Area Under the Curve and Rutland-Patlak methods. Drainage curves were classified as normal, borderline or accumulation patterns by both the techniques.Results: Fifty-two children were studied, 14 with bilateral involvement. A total of 104 kidney-urinary tracts were considered: 38 normal and 66 dilated. Considering Area Under the Curve and Rutland-Patlak for SRF, the intra-and inter-reader agreements of functional MR urography had excellent and good results, respectively, and the two techniques demonstrated a good concordance (r2: 67% for Area Under the Curve and 72% for Rutland-Patlak). Considering drainage curves, the inter-readers agreement Damasio et al. fMRU vs DRS in Children for functional MR urography and the concordance between the two techniques were moderate (Cohen's k, respectively, 55.7 and 56.3%).Conclusions: According to our results, there are no significant differences between functional MR urography and DRS in measuring volumetric SRF and in the classification of drainage curves in patients with congenital anomalies of the kidney and urinary tract.Keywords: obstructive uropathy, dynamic renal scintigraphy, functional magnetic resonance urography, congenital anomalies of the kidney and urinary tract, CAKUT

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Damasio

Bodria

Dolores³

et al. 2020

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Boss et al [17] in their study of 53 children (3 months-16 years of age) with anomalies of the urinary tract, found that the split renal function assessed by MRI showed a very good concordance with the MAG3 reference standard with a correlation coefficient of r=0.95. Additionally, three dimensional images depicted anatomical anomalies very well in all patients.…”

Section: Discussionmentioning

confidence: 93%

Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study

Sivakumar

Indiran

Sathyanathan

2018

Turkish Journal of Urology

View full text Add to dashboard Cite

Cite this article as: : Sivakumar V, Indiran V, Sathyanathan BP. Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study. Turk J Urol 2018; 44(1): 45-50. ORCID IDs of the authors:V.N.S. 0000-0002-5254-8559; V.I. 0000-0001-5296-0175; B.P.S. 0000-0002-4057-0054. ABSTRACTObjective: The aim of this study was to evaluate and compare the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging (dMRI) and isotope renogram in the functional evaluation of pelviureteric junction obstruction (PUJO). Material and methods:Forty-two patients included in the study were investigated with isotope renogram and subsequently, subjected to dMRI. Time-activity curves were generated for both isotope renogram and dMRI. Out of the 42 cases, 9 cases were conservatively managed. Thirty-three cases were taken up for surgical intervention.Results: Of 33 patients taken up for surgical intervention, 12 underwent laparoscopic nephrectomy and 21 of them pyeloplasty. The mean glomerular filtration rates (GFRs) as measured by isotope renogram and dMRI were 22.5+4.2 mL/min and 23.8+3.1 mL/min respectively. The calculation of GFR by isotope renogram, showed good correlation with that of dMRI with correlation coefficient of 0.93. The dMRI was able to reveal the functional status of the renal unit accurately. dMRI did not yield false positive results with 20 of 21 patients scheduled for pyeloplasty and 11 of 12 patients scheduled for nephrectomy. Isotope renogram had a false positive result in 3 cases compared with surgical diagnosis. Conclusion:Analysis of renal function using dMRI yielded results comparable to those of renal scintigraphy, with superior spatial and contrast resolution. It was also better in prompting management decisions with respect to the obstructed systems. dMRI can be used as a "one stop imaging examination" that can replace different imaging methods used for morphological, etiological and functional evaluation of PUJO.

show abstract

“…For patients with renal masses , Winter et al 16 used a view-sharing method, time-resolved angiography with stochastic trajectories (TWIST), to achieve dynamic imaging with spatial resolution of 2.6×2.6×2.6 mm 3 and temporal resolution of 2.5 sec. Boss et al 17 used a more traditional method, navigator gating, to achieve free-breathing acquisition for pediatric patients .…”

Section: Contrast-enhanced Mrimentioning

confidence: 99%

“…For patients with ureter diseases , Boss et al 17 proposed a new MR urography protocol consisting of both 2D and 3D acquisitions. The fast 2D imaging provided estimate of split renal function and of urinary excretion, and the high-resolution 3D images gave confident structural delineation of ureteropelvic junction obstruction .…”

Section: Contrast-enhanced Mrimentioning

confidence: 99%

Functional Magnetic Resonance Imaging of the Kidneys—With and Without Gadolinium-Based Contrast

Zhang

2017

Advances in Chronic Kidney Disease

View full text Add to dashboard Cite

Assessment of renal function with magnetic resonance imaging (MRI) has been actively explored in the past decade. In this review, we introduce the principle of MRI, and review recent progress of MRI methods (contrast-enhanced and non-contrast) in assessing renal function. Contrast-enhanced MRI using ultra-low dose of gadolinium-based agent has been validated for measuring single-kidney glomerular filtration rate (GFR) and renal plasma flow (RPF) accurately. For routine functional test, contrast-enhanced MRI may not replace the simple serum-creatinine method. However, for patients with renal diseases, it is often worthy to perform MRI to accurately monitor renal function, particularly for the diseased kidney. As contrast-enhanced MRI is already an established clinical tool for characterizing renal structural abnormalities, including renal mass and ureteral obstruction, it is possible to adapt the clinical MRI protocol to measure single-kidney GFR and RPF, as demonstrated by recent studies. What makes MRI unique is the promise of its non-contrast methods. These methods include arterial spin labeling (ASL) for tissue perfusion, blood oxygen level dependent (BOLD) for blood and tissue oxygenation, and diffusion weighted imaging (DWI) for water diffusion. For each method, we reviewed recent findings, and summarized challenges.

show abstract

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol—comparison with MAG3 scintigraphy

Cited by 19 publications

References 22 publications

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

Dynamic MRI and isotope renogram in the functional evaluation of pelviureteric junction obstruction: A comparative study

Functional Magnetic Resonance Imaging of the Kidneys—With and Without Gadolinium-Based Contrast

Contact Info

Product

Resources

About