Dynamic MR Based Analysis of Tumor Movement in Upper and Mid Lobe Localized Lung Cancer

Kov́acs, Árṕad; Hadjiev, Janaki; Lakosi, Ferenc; Antal, Gergely; Vandulek, Csaba; Ezer, Éva Somogyiné; Bogner, Péter; Horváth, Ákos G.; Romics, Imre

doi:10.1007/s12253-008-9101-5

Cited by 6 publications

(12 citation statements)

References 31 publications

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“…Some of the more exciting advanced techniques are outlined in this paper; many fall within the realm of so called “functional MRI”. Hence this term has been adopted (and used here) to describe any MRI technique capable of demonstrating information in addition to the anatomical images more routinely acquired ( 11 – 13 ). As a general description, functional MRI is used to define techniques that probe the status of the tumor itself.…”

Section: Resultsmentioning

confidence: 99%

The Potential for an Enhanced Role for MRI in Radiation-Therapy Treatment Planning

Metcalfe

Liney

Holloway

et al. 2013

Technol Cancer Res Treat

166

155

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The exquisite soft-tissue contrast of magnetic resonance imaging (MRI) has meant that the technique is having an increasing role in contouring the gross tumor volume (GTV) and organs at risk (OAR) in radiation therapy treatment planning systems (TPS). MRI-planning scans from diagnostic MRI scanners are currently incorporated into the planning process by being registered to CT data. The soft-tissue data from the MRI provides target outline guidance and the CT provides a solid geometric and electron density map for accurate dose calculation on the TPS computer. There is increasing interest in MRI machine placement in radiotherapy clinics as an adjunct to CT simulators. Most vendors now offer 70 cm bores with flat couch inserts and specialised RF coil designs. We would refer to these devices as MR-simulators. There is also research into the future application of MR-simulators independent of CT and as in-room image-guidance devices. It is within the background of this increased interest in the utility of MRI in radiotherapy treatment planning that this paper is couched. The paper outlines publications that deal with standard MRI sequences used in current clinical practice. It then discusses the potential for using processed functional diffusion maps (fDM) derived from diffusion weighted image sequences in tracking tumor activity and tumor recurrence. Next, this paper reviews publications that describe the use of MRI in patient-management applications that may, in turn, be relevant to radiotherapy treatment planning. The review briefly discusses the concepts behind functional techniques such as dynamic contrast enhanced (DCE), diffusion-weighted (DW) MRI sequences and magnetic resonance spectroscopic imaging (MRSI). Significant applications of MR are discussed in terms of the following treatment sites: brain, head and neck, breast, lung, prostate and cervix. While not yet routine, the use of apparent diffusion coefficient (ADC) map analysis indicates an exciting future application for functional MRI. Although DW-MRI has not yet been routinely used in boost adaptive techniques, it is being assessed in cohort studies for sub-volume boosting in prostate tumors.

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Section: Resultsmentioning

confidence: 99%

The Potential for an Enhanced Role for MRI in Radiation-Therapy Treatment Planning

Metcalfe

Liney

Holloway

et al. 2013

Technol Cancer Res Treat

166

155

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“…In a study including 24 patients with stage II-IV LC, Kovacs et al performed dynamic MRI examination in the axial, sagittal and coronal planes during FB (100 section/30 seconds) (18). In this study, the amount of tumor motion in AP, CC, and ML directions were determined by a software program for upper and lower lobe lung tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The average amounts of tumor motion were determined as AP 0.11 cm, ML 0.11 cm, and CC 0.27 cm. These measurements were recognized as PTV safety margins that should be considered in the 3DCRT of patients with LC (18).…”

Section: Discussionmentioning

confidence: 99%

Correlation Between CT-Simulator and Dynamic Magnetic Resonance Images in Determining The Location of Gross Tumor Volume in Radiotherapy Treatment Planning for Lung Cancer

Nasir¹,

Yurt²,

Karabay³

et al. 2019

J Basic Clin Health Sci

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Objective: This study aimed to determine the accuracy of the average tumor location in CT-simulator images and PTV margins in radiotherapy treatment planning by detecting lung tumor mobility in dynamic MRI scans of patients presenting with lung cancer. Materials and Method: Dynamic MRI examination was performed in 12 lung cancer patients scheduled for 3-dimensional conformal RT (3D-CRT) using CT-simulator. In this study, maximum tumor displacement (CC-MRI, ML-MRI, AP-MRI) was measured that occurred in CC, AP and ML axes in expiratory and inspiratory phases of dynamic MRI. The distance from the upper limit of GTV to the reference line (CC-CT) was measured in CT-simulator images. CC-CT and CCmean-MRI values were compared with the Wilcoxon signed-rank test. Furthermore, correlation of these values was evaluated with Spearman's correlation test. Results: In comparison of CC-CT and CCmean-MRI values, no statistically significant difference was detected between CT-simulator and dynamic MRI modalities (p=0.172). In addition, a high level of correlation was found between these two imaging methods (p<0.0001). Conclusion: In our study, the maximum difference between the mean and the CC distances from the upper limit of GTV to the reference line at inspiration and expiration phases in dynamic MR images was 0.4 cm. In general, it can be concluded that the tumor location detected in CTsimulator and dynamic MRI correlate well. However, tumor mobility during respiration is high particularly for small and/or, peripheral and/or lower lobe tumors; thus for such cases it is recommended to get use of dynamic MRI in radiotherapy treatment planning.

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“…cardiac arrhythmia) often preclude the use of a large number of repetitions. Faster approaches have recently been developed for estimation of 2D lung tissue movement 29 but these cannot be applied to other tissue sites or to a clinical setting as inhaled hyperpolarized 3 He gas was used as a contrast medium, thus accelerating the image acquisition.…”

Section: Introductionmentioning

confidence: 99%

“…As the above review demonstrates current SPAMM tagged MRI methods often require a large number of repetitions. This is however undesirable for biomechanical application such as muscle indentation since it: 1) causes volunteer discomfort, 2) results in long scanning times, 3) hinders the analysis of dynamic biomechanical tissue responses e.g. visco-elasticity and pre-conditioning and, 4) places repeatability constraints on both the imaging and load inducing devices.…”

Section: Introductionmentioning

confidence: 99%

Validation of SPAMM tagged MRI based measurement of 3D soft tissue deformation

Moerman¹,

Sprengers²,

Simms³

et al. 2011

Medical Physics

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The subvoxel accuracy and precision demonstrated in the phantom in combination with the precision comparison between the phantom and the volunteer data provide confidence in the methods presented for measurement of soft tissue deformation in vivo. To the author's knowledge, since only six acquisitions are required, the presented methodology is the fastest SPAMM tagged MRI method currently available for the noninvasive measurement of quasistatic 3D soft tissue deformation.

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Dynamic MR Based Analysis of Tumor Movement in Upper and Mid Lobe Localized Lung Cancer

Cited by 6 publications

References 31 publications

The Potential for an Enhanced Role for MRI in Radiation-Therapy Treatment Planning

The Potential for an Enhanced Role for MRI in Radiation-Therapy Treatment Planning

Correlation Between CT-Simulator and Dynamic Magnetic Resonance Images in Determining The Location of Gross Tumor Volume in Radiotherapy Treatment Planning for Lung Cancer

Validation of SPAMM tagged MRI based measurement of 3D soft tissue deformation

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